Hypoxic viable tissue in human chronic cerebral ischemia because of unilateral major cerebral artery steno-occlusive disease

• Project/Area Number: 24592143
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cerebral neurosurgery
• Research Institution: Iwate Medical University
• Principal Investigator: OGASAWARA Kuniaki 岩手医科大学, 医学部, 教授 (00305989)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 低酸素細胞 / 貧困灌流 / 慢性脳虚血 / 脳酸素摂取率 / 脳酸素代謝量 / PET / 脳主幹動脈閉塞 / ヒト / 脳酸素代謝 / FRP-170 PET / 認識機能

Outline of Final Research Achievements

(18)F-FRP170 PET was performed, and cerebral blood flow and metabolism were assessed using (15)O-gas PET in 20 healthy subjects and 52 patients. A region of interest (ROI) was automatically placed in 3 segments of the middle cerebral artery territory in both cerebral hemispheres with a 3-dimensional stereotaxic ROI template using SPM2, and each PET value was determined in each ROI. The ratio of values in the affected versus contralateral hemispheres was calculated for the (18)F-FRP170 PET image.
The specificity and positive-predictive value for a combination of an elevated oxygen extraction fraction and a moderately reduced cerebral oxygen metabolism for detection of an abnormally elevated (18)F-FRP170 ratio (19 ROIs: 12%) were significantly greater than those for the individual categories (elevated oxygen extraction fraction, moderately reduced cerebral oxygen metabolism, or reduced cerebral blood flow).

Research Products

• [Journal Article] Does Preoperative Measurement of Cerebral Blood Flow with Acetazolamide Challenge in Addition to Preoperative Measurement of Cerebral Blood Flow at the Resting State Increase the Predictive Accuracy of Development of Cerebral Hyperperfusion after Carotid Endarterectomy? Results from 500 Cases with Brain Perfusion Single-photon Emission Computed Tomography Study (2015)
  • Author(s): Oshida S, Ogasawara K, Saura H, Yoshida K, Fujiwara S, Kojima D, Kobayashi M, Yoshida K, Kubo Y, Ogawa A
  • Journal Title: Neurologia medico-chirurgica Volume: 55 Issue: 2 Pages: 141-148
  • DOI: 10.2176/nmc.oa.2014-0269
  • NAID: 130004922272
  • ISSN: 0470-8105, 1349-8029
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Post-Carotid Endarterectomy Changes of Cerebral Glucose Metabolism on 18F-Fluoro-Deoxyglucose Positron Emission Tomography Associated with Postoperative Improvement and Impairment in Cognitive Function (2015)
  • Author(s): Yoshida K, Ogasawara K, Saura H, Saito H, Kobayashi M, Yoshida K, Terasaki K, Fujiwara S, Ogawa A
  • Journal Title: J Neurosurg Volume: in press
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Hypoxic viable tissue in human chronic cerebral ischemia because of unilateral major cerebral artery steno-occlusive disease. (2015)
  • Author(s): Saura H, Ogasawara K, Beppu T, Yoshida K, Kobayashi M, Yoshida K, Terasaki K, Takai Y, Ogawa A.
  • Journal Title: Stroke Volume: 46 Issue: 5 Pages: 1250-1256
  • DOI: 10.1161/strokeaha.114.008238
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Preoperative visualization of the marginal tentorial artery as an unusual collateral pathway in a patient with symptomatic bilateral vertebral artery occlusion undergoing arterial bypass surgery: A 7.0-T magnetic resonance imaging study. (2014)
  • Author(s): Sato Y, Ogasawara K, Yoshida K, Sasaki M
  • Journal Title: Surg Neurol Int Volume: 5 Issue: 1 Pages: 157-157
  • DOI: 10.4103/2152-7806.143760
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Biological characteristics of a cerebellar mass regrowing after removal in a patient with lhermitte-duclos disease: emission tomography studies. (2014)
  • Author(s): Saito H, Ogasawara K, Beppu T, Matsuura H, Terasaki K.
  • Journal Title: Case Rep Neurol Volume: 6 Issue: 1 Pages: 96-100
  • DOI: 10.1159/000362118
  • Peer Reviewed
• [Journal Article] Combination of blood flow asymmetry in the cerebral and cerebellar hemispheres on brain perfusion SPECT predicts 5-year outcome in patients with symptomatic unilateral major cerebral artery occlusion. (2014)
  • Author(s): Nomura J, Ogasawara K, Saito H, Terasaki K, Matsumoto Y, Takahashi Y, Ogasawara Y, Saura H, Yoshida K, Sato Y, Kubo Y, Ogawa A
  • Journal Title: Neurol Res. Volume: 36(3) Issue: 3 Pages: 262-9
  • DOI: 10.1179/1743132813y.0000000300
  • Peer Reviewed
• [Journal Article] Combined measurement of cerebral and cerebellar blood flow on preoperative brain perfusion SPECT imaging predicts development of new cerebral ischemic events after endarterectomy for symptomatic unilateral cervical carotid stenosis. (2013)
  • Author(s): Oikawa K, Ogasawara K, Saito H, Yoshida K, Saura H, Sato Y, Terasaki K, Wada T, Kubo Y.
  • Journal Title: Clin Nucl Med Volume: 38 Issue: 12 Pages: 957-961
  • DOI: 10.1097/rlu.0000000000000279
  • Peer Reviewed
• [Journal Article] anges in cognitive function after carotid endarterectomy in older patients: comparison with younger patients. (2013)
  • Author(s): Takahashi Y, Ogasawara K, Matsumoto Y, Kobayashi M, Yoshida K, Kubo Y, Beppu T, Murakami T, Nanba T, Ogawa A.
  • Journal Title: Neurol Med Chir (Tokyo) Volume: 53 Pages: 353-359
  • Peer Reviewed
• [Journal Article] Postoperative increase in cerebral white matter fractional anisotropy on diffusion tensor magnetic resonance imaging is associated with cognitive improvement after uncomplicated carotid endarterectomy: tract-based spatial statistics analysis. (2013)
  • Author(s): Sato Y, Ito K, Ogasawara K, Sasaki M, Kudo K, Murakami T, Nanba T, Nishimoto H, Yoshida K, Kobayashi M, Kubo Y, Mase T, Ogawa A
  • Journal Title: Neurosurgery. Volume: 73(4) Issue: 4 Pages: 592-8
  • DOI: 10.1227/neu.0000000000000013
  • Peer Reviewed
• [Journal Article] Detection of misery perfusion in the cerebral hemisphere with chronic unilateral major cerebral artery steno-occlusive disease using crossed cerebellar hypoperfusion: comparison of brain SPECT and PET imaging. (2013)
  • Author(s): Matsumoto Y, Ogasawara K, Saito H, Terasaki K, Takahashi Y, Ogasawara Y, Kobayashi M, Yoshida K, Beppu T, Kubo Y, Fujiwara S, Tsushima E, Ogawa A
  • Journal Title: Eur J Nucl Med Mol Imaging. Volume: 40(10) Issue: 10 Pages: 1573-81
  • DOI: 10.1007/s00259-013-2463-2
  • Peer Reviewed
• [Journal Article] Postoperative Changes in Cerebral Metabolites Associated with Cognitive Improvement and Impairment after Carotid Endarterectomy: A 3T Proton MR Spectroscopy Study. (2013)
  • Author(s): Saito H, Ogasawara K, Nishimoto H, Yoshioka Y, Murakami T, Fujiwara S, Sasaki M, Kobayashi M, Yoshida K, Kubo Y, Beppu T, Ogawa A
  • Journal Title: AJNR Am J Neuroradiol Volume: 000 Pages: 0-0
  • Peer Reviewed
• [Journal Article] Growth Hormone-Producing Pituitary Adenoma Regrowing as Pituitary Adenoma with Neuronal Choristoma 14 Years After Tumor Removal. (2013)
  • Author(s): Sato Y, Wada T, Nishikawa Y, Yoshida K, Kurose A, Ogawa A, Ogasawara K
  • Journal Title: World Neurosurg Volume: 0000 Pages: 0-0
  • Peer Reviewed
• [Journal Article] Postoperative increase in cerebral white matter fractional anisotropy on diffusion tensor magnetic resonance imaging is associated with cognitive improvement after uncomplicated carotid endarterectomy: tract-based spatial statistics analysis. (2013)
  • Author(s): Sato Y, Ito K, Ogasawara K, Sasaki M, Kudo K, Murakami T, Nanba T, Nishimoto H, Yoshida K, Kobayashi M, Kubo Y, Mase T, Ogawa A
  • Journal Title: Neurosurgery Volume: 0000 Pages: 0-0
  • Peer Reviewed
• [Journal Article] Changes in Cognitive Function after Carotid Endarterectomy in Older Patients: Comparison with Younger Patients. (2013)
  • Author(s): Matsumoto Y, Ogasawara K, Saito H, Terasaki K, Takahashi Y, Ogasawara Y, Kobayashi M, Yoshida K, Beppu T, Kubo Y, Fujiwara S, Tsushima E, Ogawa A
  • Journal Title: Eur J Nucl Med Mol Imag Volume: 0000 Pages: 0-0
  • NAID: 10031173717
  • Peer Reviewed
• [Journal Article] Changes in Cognitive Function after Carotid Endarterectomy in Older Patients: Comparison with Younger Patients. (2013)
  • Author(s): Takahashi Y, Ogasawara K, Matsumoto Y, Kobayashi M, Yoshida K, Kubo Y, Beppu T, Murakami T, Nanba T, Ogawa A
  • Journal Title: Neurol Med Chirur Volume: 0000 Pages: 0-0
  • NAID: 10031173717
  • Peer Reviewed
• [Journal Article] Unusual growth pattern of a meningioma. (2012)
  • Author(s): Kashimura H, Mase T, Ogasawara K, Kurose A
  • Journal Title: Surg Neurol Int Volume: 3 Pages: 63-63
  • Peer Reviewed
• [Journal Article] Prediction of motor function outcome after intracerebral hemorrhage using fractional anisotropy calculated from diffusion tensor imaging. (2012)
  • Author(s): Kuzu Y, Inoue T, Kanbara Y, Nishimoto H, Fujiwara S, Ogasawara K, Ogawa A.
  • Journal Title: Cerebrovasc Dis Volume: 33 Pages: 566-573
  • Peer Reviewed
• [Journal Article] Use of magnetic resonance imaging to identify the edge of a dural tear in an infant with growing skull fracture: a case study. (2012)
  • Author(s): Matsuura H, Omama S, Yoshida Y, Fujiwara S, Honda T, Akasaka M, Kamei A, Ogasawara K
  • Journal Title: Childs Nerv Syst Volume: 28 Pages: 1951-1954
  • Peer Reviewed
• [Journal Article] Postoperative cerebral white matter damage associated with cerebral hyperperfusion and cognitive impairment after carotid endarterectomy: a diffusion tensor magnetic resonance imaging study. (2012)
  • Author(s): Nanba T, Ogasawara K, Nishimoto H, Fujiwara S, Kuroda H, Sasaki M, Kudo K, Suzuki T, Kobayashi M, Yoshida K, Ogawa A
  • Journal Title: Cerebrovasc Dis Volume: 34 Pages: 358-367
  • Peer Reviewed
• [Presentation] 脳主幹動脈狭窄閉塞性病変による慢性虚血脳における低酸素組織の存在：18F-FRP170による検討 (2015)
  • Author(s): 佐浦宏明、小笠原邦昭
  • Organizer: 第４０回日本脳卒中学会
  • Place of Presentation: 広島
  • Year and Date: 2015-03-26
• [Presentation] ダイアモックス注射薬の副作用問題にどう対応するか (2015)
  • Author(s): 小笠原邦昭
  • Organizer: 第３８回日本脳神経CI学会
  • Place of Presentation: 名古屋
  • Year and Date: 2015-02-13
  • Invited
• [Presentation] 脳主幹動脈狭窄閉塞性病変による慢性虚血脳における低酸素組織の存在：18F-FRP170による検討 (2014)
  • Author(s): 佐浦宏明、小笠原邦昭
  • Organizer: 第26回日本脳循環代謝学会
  • Place of Presentation: 岡山
  • Year and Date: 2014-11-21
• [Presentation] 脳主幹動脈狭窄閉塞性病変による慢性虚血脳における低酸素組織の存在：18F-FRP170による検討 (2014)
  • Author(s): 佐浦宏明、小笠原邦昭
  • Organizer: 第７３回日本脳神経外科学会総会
  • Place of Presentation: 東京
  • Year and Date: 2014-10-09
• [Presentation] 頸動脈内膜剥離術における認知機能変化の病態解明：高磁場MRIおよびSPECTによる可視化 (2014)
  • Author(s): 小笠原邦昭
  • Organizer: Stroke 2014
  • Place of Presentation: 大阪
  • Invited
• [Presentation] 頸動脈内膜剥離術後の認知機能改善および悪化：主観的評価と客観的評価の比較 (2013)
  • Author(s): 斎藤秀夫、小笠原邦昭
  • Organizer: 第22回日本脳ドック学会総会
  • Place of Presentation: 仙台市
• [Presentation] 高齢者における頸動脈内膜剥離術後認知機能変化：若年者の比較 (2013)
  • Author(s): 斎藤秀夫、小笠原邦昭
  • Organizer: 第12回日本頚部脳血管治療学会
  • Place of Presentation: 東京
• [Presentation] 大脳半球白質のfractional anisotropy値の術後増加は頸動脈内膜剥離術後認知機能改善に関与する (2013)
  • Author(s): 南波孝昌、小笠原邦昭
  • Organizer: 第12回日本頚部脳血管治療学会
  • Place of Presentation: 東京
• [Presentation] 高齢者における頸動脈内膜剥離術後認知機能変化：若年者の比較 (2013)
  • Author(s): 斎藤秀夫、小笠原邦昭
  • Organizer: 日本脳神経外科学会第72回学術総会
  • Place of Presentation: 横浜
• [Presentation] Multi-voxel proton magnetic resonance spectroscopyを用いた大脳半球深部白質の脳温度イメージング (2013)
  • Author(s): 南波孝昌、小笠原邦昭
  • Organizer: 日本脳神経外科学会第72回学術総会
  • Place of Presentation: 横浜
• [Presentation] Ｃｅｎｔｒａｌ ｂｅｎｚｏｄｉａｚｅｐｉｎｅ ｒｅｃｅｐｔｏｒ ｂｉｄｉｎｇ ｐｏｔｅｎｔｉａｌ／ｃｅｒｅｂｒａｌ ｂｌｏｏｄ ｆｌｏｗ ｉｍａｇｅｓ ｏｎ ＳＰＥＣＴ ｃｏｒｒｅｌａｔｅ ｗｉｔｈ ｏｘｙｇｅｎ ｅｘｔｒａｃｔｉｏｎ ｆｒａｃｔｉｏｎ ｉｍａｇｅｓ ｏｎ ＰＥＴ (2013)
  • Author(s): Ｋｏｈｅｉ Ｃｈｉｄａ、Ｋｕｎｉａｋｉ Ｏｇａｓａｗａｒａ
  • Organizer: Ｔｈｅ ６ｔｈ Ｋｏｒｅａ－Ｊａｐａｎ ｊｏｉｎｔ ｓｔｒｏｋｅ ｃｏｎｆｅｒｅｎｃｅ
  • Place of Presentation: Osaka
• [Presentation] Multi-voxel proton magnetic resonance spectroscopyを用いた大脳半球深部白質の脳温度イメージング (2013)
  • Author(s): 南波孝昌、小笠原邦昭
  • Organizer: 第25回日本脳循環代謝学会総会
  • Place of Presentation: 札幌
• [Presentation] Crossed cerebellar diaschisisを用いた一側性脳主幹動脈閉塞性病変における貧困灌流の検出 (2013)
  • Author(s): 斎藤秀夫、小笠原邦昭
  • Organizer: 第25回日本脳循環代謝学会総会
  • Place of Presentation: 札幌
• [Presentation] 慢性脳虚血性病変に対する血行再建術と頭痛 (2013)
  • Author(s): 小笠原邦昭
  • Organizer: 第41回日本頭痛学会
  • Place of Presentation: 盛岡
  • Invited
• [Presentation] 当施設におけるCEAの基本とトレーニング (2012)
  • Author(s): 小笠原邦昭
  • Organizer: 第41回日本脳卒中の外科学会(Stroke2012)
  • Place of Presentation: 福岡
  • Invited
• [Presentation] 頸動脈内膜剥離術後認知機能の改善と悪化：主観的評価と神経心理検査との比較 (2012)
  • Author(s): 小笠原邦昭、小林正和、吉田研二、鈴木太郎、山下武志、小川 彰
  • Organizer: 第11回日本頸部脳血管治療学会
  • Place of Presentation: 名古屋
• [Presentation] 頚動脈内膜はくり術後の認知機能変化：改善？不変？それとも悪化 (2012)
  • Author(s): 小笠原邦昭
  • Organizer: 第15回日本病院脳神経外科学会
  • Place of Presentation: 函館
  • Invited
• [Presentation] Hemodynamic compromise and stroke recurrence in patients with symptomatic major cerebral artery occlusion (2012)
  • Author(s): Ogasawara K
  • Organizer: APSC2012
  • Place of Presentation: Tokyo
  • Invited
• [Presentation] 術前の脳循環動態は頚動脈内膜剥離術後認知機能の変化の変化を予知する (2012)
  • Author(s): 小笠原邦昭、小林正和、吉田研二、小川 彰
  • Organizer: (社)日本脳神経外科学会第71回学術総会
  • Place of Presentation: 大阪