Japanese brain-database of sulcal and gyral patterns based on functional information contribute to clinical application

• Project/Area Number: 24592146
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cerebral neurosurgery
• Research Institution: Tokyo Women's Medical University
• Principal Investigator: Tamura Manabu 東京女子医科大学, 医学部, 講師 (80453174)
• Co-Investigator(Renkei-kenkyūsha): Muragaki Yoshihiro 東京女子医科大学, 医学部, 教授 (70210028) ; Sakai Kuniyoshi 東京大学, 総合文化研究科, 教授 (10251216)
• Research Collaborator: Francois Mangin Jean Neurospin, Biomedical Imaging Institute, CEA
• Project Period (FY): 2012-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: brain database / sulal and gyral patterns / diffusion tensor imaging / focal cortical dysplasia / dystonia / 脳機能マッピング / DTI / Dystonia / 国際情報交換 / フランス / Neurospin / Glioma

Outline of Final Research Achievements

We successfully analyzed high-field magnetic MR image to get labeled sulcal and gyral patterns of cerebral cortex on the three dimensional brain surface views, comparing with the description of intra-cranial diffusion tensor imaging and functional MRI. Based on this functional database comparing to a standard brain model, the structure in patients (especially suffering from focal cortical dysplasia and brain tumor) was analyzed. This study contributed greatly to clinical application aimed for the recovery from brain deterioration as well as a possibility of clarifying the process of the cortical formation.

Research Products

• [Int'l Joint Research] Neurospin/Timone Hospital/LSIS Laboratory(France)
• [Journal Article] Difficulty in identification of the frontal language area in patients with dominant frontal gliomas that involve the pars triangularis. (2016)
  • Author(s): Saito, T., Y. Muragaki, T. Maruyama, M. Tamura, M. Nitta, S. Tsuzuki, Y. Konishi, K. Kamata, R. Kinno, K. L. Sakai, H. Iseki and T. Kawamata
  • Journal Title: J Neurosurg Volume: Posted online on 22 Jan Issue: 4 Pages: 1-9
  • DOI: 10.3171/2015.8.jns151204
  • Peer Reviewed
• [Journal Article] Calcification on CT is a simple and valuable preoperative indicator of 1p/19q loss of heterozygosity in supratentorial brain tumors that are suspected grade II and III gliomas. (2016)
  • Author(s): Saito, T., Y. Muragaki, T. Maruyama, T. Komori, M. Tamura, M. Nitta, S. Tsuzuki and T. Kawamata
  • Journal Title: Brain Tumor Pathol. Volume: Posted online on 5 Feb Issue: 3 Pages: 1-8
  • DOI: 10.1007/s10014-016-0249-5
  • Peer Reviewed
• [Journal Article] Why Intra-epidermal Electrical Stimulation Achieves Stimulation of Small Fibres Selectively: A Simulation Study (2016)
  • Author(s): Motogi, J., Sugiyama, Y., Laakso, I., Hirata, A., Inui, K., Tamura, M., Muragaki, Y.
  • Journal Title: Physics in Medicine and Biology Volume: in press Pages: 1-12
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] 手術支援機器による術中判断と行動 (2016)
  • Author(s): 村垣善浩, 伊関洋, 丸山隆志, 新田雅之, 齋藤太一, 田村学, 都築俊介, 安田崇之, 岡田芳和, 川俣貴一
  • Journal Title: 脳神経外科ジャーナル Volume: in press
  • NAID: 130005253270
  • Peer Reviewed
• [Journal Article] Strategy of Surgical Resection for Glioma Based on Intraoperative Functional Mapping and Monitoring (2015)
  • Author(s): Tamura M, Muragaki Y, Saito T, Maruyama T, Nitta M, Tsuzuki S, Iseki H, Okada Y
  • Journal Title: Neurologia medico-chirurgica Volume: 55 Issue: 5 Pages: 383-398
  • DOI: 10.2176/nmc.ra.2014-0415
  • NAID: 130005069869
  • ISSN: 0470-8105, 1349-8029
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Proposed therapeutic strategy for adult low-grade glioma based on aggressive tumor resection. (2015)
  • Author(s): Nitta M, Muragaki Y, Maruyama T, Ikuta S, Komori T, Maebayashi K, Iseki H, Tamura M, Saito T, Okamoto S, Chernov M, Hayashi M, Okada Y.
  • Journal Title: Neurosurg Focus Volume: 38（1） Issue: 1 Pages: E7-E7
  • DOI: 10.3171/2014.10.focus14651
  • Peer Reviewed / Open Access
• [Journal Article] 術中言語検査における音声情報を利用した覚醒下手術映像記録のタグ付け (2015)
  • Author(s): 西村俊彦, 長尾智晴, 伊関洋, 村垣善浩, 田村学, 南伸二
  • Journal Title: 医療情報学 Volume: 34-6 Pages: 271-279
  • NAID: 130005148402
  • Peer Reviewed
• [Journal Article] 「覚醒下手術ガイドライン」の解説 (2015)
  • Author(s): 田村学, 丸山隆志, 村垣善浩
  • Journal Title: 脳神経外科速報 Volume: 25-12 Pages: 1292-1299
• [Journal Article] 頭頂葉言語野近傍神経膠腫に対し,硬膜下電極マッピングと覚醒下手術の併用が機能温存と積極的摘出の両立に有効であった1例 (2015)
  • Author(s): 竹林研人, 齋藤太一, 新田雅之, 田村学, 丸山隆志, 村垣善浩, 岡田芳和.
  • Journal Title: Neurological Surgery Volume: 43 Pages: 63-68
  • Peer Reviewed
• [Journal Article] Intraoperative Functional Mapping and Monitoring during Glioma Surgery (2015)
  • Author(s): Saito T, Muragaki Y, Maruyama, Tamura M, Nitta M, Okada Y.
  • Journal Title: Neurologia medico-chirurgica Volume: 55 Issue: 1 Pages: 1-13
  • DOI: 10.2176/nmc.ra.2014-0215
  • NAID: 130004922268
  • ISSN: 0470-8105, 1349-8029
  • Peer Reviewed / Open Access
• [Journal Article] Glioma Surgery based on Anatomical Structure of the White Matter (2015)
  • Author(s): 丸山隆志, 村垣善浩, 新田雅之, 齋藤太一, 田村学, 伊関洋, 岡田芳和
  • Journal Title: Japanese Journal of Neurosurgery Volume: 24 Issue: 2 Pages: 76-84
  • DOI: 10.7887/jcns.24.76
  • NAID: 130004842138
  • ISSN: 0917-950X, 2187-3100
  • Peer Reviewed / Open Access
• [Journal Article] Strategy of Surgical Resection for Glioma Based on Intraoperative Functional Mapping and Monitoring. (2015)
  • Author(s): Tamura M, Muragaki Y, Saito T, Maruyama T, Nitta M, Tsuzuki S, Iseki H, Okada Y.
  • Journal Title: Neurol Med Chir (Tokyo) Volume: 55
  • NAID: 130005069869
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Intraoperative cortico-cortical evoked potentials for the evaluation of language function during brain tumor resection. initial experience with 13 cases. (2014)
  • Author(s): Saito T, Tamura M, Muragaki Y, Maruyama T, Kubota Y, Fukuchi S, Nitta M, Chernov M, Okamoto S, Sugiyama K, Kurisu K, Sakai KL, Okada Y, Iseki H
  • Journal Title: J Neurosurg Volume: 121 Issue: 4 Pages: 1-12
  • DOI: 10.3171/2014.4.jns131195
  • Peer Reviewed
• [Journal Article] Functional Plasticity of Language Confirmed with Intraoperative Electrical Stimulations and Updated Neuronavigation: Case Report of Low-Grade Glioma of the Left Inferior Frontal Gyrus (2014)
  • Author(s): Saito T, Muragaki Y, Miura I, Tamura M, Maruyama T, Nitta M, Kurisu K, Iseki H, Okada Y.
  • Journal Title: Neurologia medico-chirurgica Volume: 54 Issue: 7 Pages: 587-592
  • DOI: 10.2176/nmc.cr.2013-0248
  • NAID: 130004448325
  • ISSN: 0470-8105, 1349-8029
  • Peer Reviewed / Open Access
• [Journal Article] Automatic Detection of Electrical Stimulation Positions in Videos of Cortical Mapping in Awake Surgery (2014)
  • Author(s): 菅沼雅徳, 長尾智晴, 田村学, 村垣善浩, 伊関洋.
  • Journal Title: Medical Imaging Technology Volume: 32 Issue: 4 Pages: 272-281
  • DOI: 10.11409/mit.32.272
  • NAID: 130004691593
  • ISSN: 0288-450X, 2185-3193
  • Peer Reviewed / Open Access
• [Journal Article] Advanced image co-registration within Leksell workstation for planning of glioma surgery: Initial experience. (2013)
  • Author(s): Tamura M, Hayashi M, Konishi Y, Tamura N, Regis J, Mangin J.F, Taira T, Okada Y, Muragaki Y, Iseki H.
  • Journal Title: JNLS Report Volume: 74 Issue: 02 Pages: 118-122
  • DOI: 10.1055/s-0033-1358380
  • Peer Reviewed
• [Journal Article] Usufulness of Leksell GammaPlan for preoperative planning of brain tumor resection: Delineation of the cranial nerves and fusion of the neuroimaging data, including DTI (2013)
  • Author(s): M.Tamura, Y.Konishi, N.Tamura, M.Hayashi, N.Nakao, U.Yuji, T.Itakura, J.Regis, JF.Mangin, Y.Muragaki, H.Iseki
  • Journal Title: Acta Neurochirurgica Suppl Volume: 16 Pages: 179-185
  • DOI: 10.1007/978-3-7091-1376-9_27
  • ISBN: 9783709113752, 9783709113769
• [Journal Article] MRI Based Sulcal Pattern Analysis for Diagnosis and Clinical Application in Neurosurgery (2012)
  • Author(s): M. Tamura, H. Nishibayashi, M. Ogura, Y. Uematsu, T. Itakura, J.F. Mangin, J. Regis, S. Ikuta, K. Yoshimitsu, T. Suzuki, C. Niki, Y. Muragaki, and H. Iseki
  • Journal Title: Computer Aided Surgery, Proceedings in Information and Communications Technology Volume: 3 Pages: 135-143
  • DOI: 10.1007/978-4-431-54094-6_15
  • ISBN: 9784431540939, 9784431540946
  • Peer Reviewed
• [Presentation] 術中MRIと連動するマッピング位置情報のデジタル化 － 未来予測手術のためのデータベース構築 － (2016)
  • Author(s): 田村学, 丸山隆志, 佐藤生馬, Mangin Jean-Francois, 新田雅之, 正宗賢, 山田浩之, 川俣貴一, 伊関洋, 村垣善浩
  • Organizer: 第25回脳神経外科手術と機器学会
  • Place of Presentation: 朱鷺メッセ 新潟コンベンションセンター（新潟市）
  • Year and Date: 2016-03-25
• [Presentation] 神経膠腫摘出のための覚醒下皮質電気刺激言語マッピングにおける精度検討 (2016)
  • Author(s): 田村学, 丸山隆志, 新田雅之, 齋藤太一, 南伸二, 生田聡子, 吉光喜太郎, 岡本淳, 正宗賢, 伊関洋, 金野竜太, 酒井邦嘉, 川俣貴一, 村垣善浩
  • Organizer: 第18回日本ヒト脳機能マッピング学会
  • Place of Presentation: 京都大学桂キャンパス 船井哲良記念講堂（京都市）
  • Year and Date: 2016-03-08
• [Presentation] 脳腫瘍摘出のためのマッピング位置情報デジタル化と脳機能データベース構築 (2016)
  • Author(s): 田村学, 丸山隆志, Mangin Jean-Francois, 新田雅之, 齋藤太一, 生田聡子, 岡本淳, 吉光喜太郎, 小西良幸, 正宗賢, 山田浩之, 南伸二, 川俣貴一, 伊関洋, 村垣善浩
  • Organizer: 第18回日本ヒト脳機能マッピング学会
  • Place of Presentation: 京都大学桂キャンパス 船井哲良記念講堂（京都市）
  • Year and Date: 2016-03-08
• [Presentation] Digitized Brain-mapping Localization and their Compiled Brain-function Database For the Future-predicting Glioma Surgery (2016)
  • Author(s): Tamura M, Maruyama T, Mangin JF, Sato I, Nitta M, Yoshimitsu K, Konishi Y, Okamoto J, Ikuta S, Masamune K, Yamada H, Minami S, Kawamata T, Iseki H, Muragaki Y
  • Organizer: The second International Symposium on Multidisciplinary Computational Anatomy
  • Place of Presentation: 名古屋大学 東山キャンパス 野依記念学術交流館（名古屋市）
  • Year and Date: 2016-02-12
  • Int'l Joint Research
• [Presentation] 未来予測手術実現のための画像情報デジタル化と脳機能データベース構築 (2015)
  • Author(s): 田村学, 丸山隆志, Mangin JF, 新田雅之, 斉藤太一, 生田聡子, 岡本淳, 吉光喜太郎, 小西良幸, 正宗賢, 山田浩之, 南伸二, 川俣貴一, 伊関洋, 村垣善浩
  • Organizer: 第24回日本コンピュータ外科学会
  • Place of Presentation: 東京大学本郷キャンパス（文京区、東京都）
  • Year and Date: 2015-11-23
• [Presentation] 神経膠腫摘出術における覚醒下言語機能皮質マッピングの精度検討 (2015)
  • Author(s): 田村学, 丸山隆志, 新田雅之, 齋藤太一, 南伸二, 生田聡子, 正宗賢, 伊関洋, 川俣貴一, 村垣善浩
  • Organizer: 第13回日本AwakeSurgery学会
  • Place of Presentation: 名古屋国際センター（名古屋市、愛知県）
  • Year and Date: 2015-09-24
• [Presentation] Functional MRI and DTI in Evaluation of Intracranial Gliomas (2015)
  • Author(s): Tamura M, Muragaki Y, Maruyama T, Kinno R, Sakai K, Kawamata T, Masamune K, Iseki H
  • Organizer: The Educational Course “Contemporary management of intracranial gliomas
  • Place of Presentation: Nobosibirsk, Russia
  • Year and Date: 2015-08-14
  • Int'l Joint Research / Invited
• [Presentation] Preoperative MRI-based delineation of the sulcal and gyral anatomy and its usefulness for glioma resection in neurosurgery (2015)
  • Author(s): Tamura M, Maruyama T, Nitta M, Saito T, Yoshimitsu K, Konishi Y, Okamoto J, Ikuta S, Masamune K, Mangin J-F, Okada Y, Iseki H, Muragaki Y
  • Organizer: 19th annual conference of the International Society for Computer Aided Surgery (CARS)
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 2015-06-27
  • Int'l Joint Research
• [Presentation] Preoperative MRI-Based Delineation Of The Sulcal And Gyral Anatomy And Its Usefulness For Glioma Resection In Neurosurgery (2015)
  • Author(s): Tamura T, Maruyama T, Nitta M, Saito T, Yoshimitsu K, Konishi Y, Okamoto J, Ikuta S, Masamune K, Mangin JF, Okada Y, Iseki H, Muragaki Y
  • Organizer: ISCAS
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 2015-06-24
• [Presentation] 未来予測手術を見据えた覚醒下手術中の電気刺激位置情報取得 (2015)
  • Author(s): 田村学, 丸山隆志, 新田雅之, 斉藤太一, 生田聡子, 正宗賢, 山田浩之, 南伸二, 川俣貴一, 伊関洋, 村垣善浩
  • Organizer: 第15回日本術中画像情報学会
  • Place of Presentation: 東京サイエンスセンター（川崎市、神奈川県）
  • Year and Date: 2015-06-20
• [Presentation] Advantage of Leksell GammaPlan for Brain Tumor Management: Image Co-registration, Volumetry and Delineation for Brain Mapping (2015)
  • Author(s): Tamura M, Muragaki Y, Hayashi M, Konishi Y, Chernov M, Tamura N, Regis J, Masamune K, Iseki H
  • Organizer: 12th Bi-annual Congress of the International Stereotactic Radiosurgery Society (ISRS)
  • Place of Presentation: パシフィコ横浜（横浜市、神奈川県）
  • Year and Date: 2015-06-10
  • Int'l Joint Research
• [Presentation] Contemporary management of intracranial gliomas - Information-guided Surgery and Precision-guided Therapy - (2015)
  • Author(s): Tamura M, Muragaki Y, Chernov M, Iseki H, Maruyama T, Nitta M, Yoshimitsu K, Konishi Y, Ikuta S, Okamoto J, Niki C, Maeda M, Horise Y, Kishimoto S, Masamune K, Takakura K
  • Organizer: Seminar on Oncology with the XIV International Congress ‘Evidence-based Medicine - The Cornerstone of the Modern Healthcare’
  • Place of Presentation: Khabarovsk, Russia
  • Year and Date: 2015-05-25
  • Int'l Joint Research / Invited
• [Presentation] MRIからの脳溝イメージング情報を活用した脳外科手術支援 (2015)
  • Author(s): 田村学, 丸山隆志, 新田雅之, 斉藤太一, 生田聡子, 正宗賢, Jean-Francois Mangin, 岡田芳和,伊関洋, 村垣善浩
  • Organizer: 第24回脳神経外科手術と機器学会
  • Place of Presentation: ナレッジキャピタルコングレコンベンションセンター（大阪市北区）
  • Year and Date: 2015-04-03
• [Presentation] 運動野近傍脳腫瘍の術前トラクトグラフィを用いた手術戦略立案 (2014)
  • Author(s): 田村学, 丸山隆志, 新田雅之, 村垣善浩, 斉藤太一, 吉光喜太郎, 生田聡子, 小西良幸, 岡本淳, 正宗賢, 仁木千晴, 前田真法, Chernov Mikhail, 岡田芳和, 伊関洋
  • Organizer: 第23回日本コンピュータ外科学会
  • Place of Presentation: 大阪大学コンベンションセンター（大阪府吹田市）
  • Year and Date: 2014-11-30
• [Presentation] 運動野近傍神経膠腫摘出のための術前DTIの役割 (2014)
  • Author(s): 田村学, 丸山隆志, 新田雅之, 福井敦, 斉藤太一, 生田聡子, 吉光喜太郎, 小西良幸, 仁木千晴, 岡本淳, 正宗賢, 前田真法, Chernov Mikhail, 岡田芳和, 伊関洋, 村垣善浩
  • Organizer: 第32回日本脳腫瘍学会学術集会
  • Place of Presentation: シェラトン・グランデ・トーキョーベイ・ホテル（千葉件浦安市）
  • Year and Date: 2014-11-30
• [Presentation] MRI陰性のてんかん原性領域の解剖学的マーカーとして注目した脳溝形成異常 (2014)
  • Author(s): 田村学, 西林宏起, Jean-Francois Mangin, Denis Riviere, Fabrice Bartolomei, Nadine Girard, Patrick Chauvel, Jean Regis, 上松右二, 中尾直之, 岡田芳和, 伊関洋, 村垣善浩
  • Organizer: 第73回日本脳神経外科学会総会
  • Place of Presentation: グランドプリンスホテル新高輪（東京都港区）
  • Year and Date: 2014-10-09
• [Presentation] Performance Evaluation of preoperative DTI for surgical management of gliomas (2014)
  • Author(s): Tamura M, Konishi Y, Suzuki T, Maruyama T, Murgaki Y
  • Organizer: MICCAI 2014 DTI Tractography Challenge
  • Place of Presentation: Boston, USA
  • Year and Date: 2014-09-14
• [Presentation] 言語野･運動野近傍脳腫瘍手術での合併症回避を目指した術前評価･術中支援システムの構築 (2014)
  • Author(s): 田村学, 丸山隆志, 村垣善浩, 新田雅之, 齋藤太一, 金野竜太, 酒井邦嘉, Jean Francois Mangin, 岡田芳和, 伊関洋
  • Organizer: 第19回日本脳腫瘍の外科学会
  • Place of Presentation: 東京ドームホテル（東京都文京区）
  • Year and Date: 2014-09-12
• [Presentation] Role of preoperative DTI tractography for surgical management of gliomas (2014)
  • Author(s): Tamura M, Konishi Y, Suzuki Y, Maruyama T, Okada Y, Iseki H, Muragaki Y
  • Organizer: International Congress on Neuroscience
  • Place of Presentation: Krasnoyarsk, Russia
  • Year and Date: 2014-06-20
  • Invited
• [Presentation] Role of preoperative functional MRI in awake craniotomy management of gliomas (2014)
  • Author(s): Tamura M, Muragaki Y, Maruyama T, Kinno R, Sakai K.L, Okada Y, Iseki H
  • Organizer: International Congress on Neuroscience
  • Place of Presentation: Krasnoyarsk, Russia
  • Year and Date: 2014-06-19
  • Invited
• [Presentation] 異種生体情報を統合表示する術中言語機能モニタリングシステム（IEMAS）の応用展開 (2014)
  • Author(s): 田村学、丸山隆志、田中隆、福富善大、西村聡晶、別府高明、遠藤広唯、南部恭二郎、岡田芳和、村垣善浩
  • Organizer: 第23回脳神経外科手術と機器学会シンポジウム
  • Place of Presentation: ヒルトン福岡シーホーク（福岡県福岡市）
  • Year and Date: 2014-04-19
• [Presentation] The impact of image co-registration within Leksell workstation for glioma surgery management (2013)
  • Author(s): Tamura M, Maruyama T, Konishi Y, Hayashi M, Régis J, Mangin J-F, Taira T, Okada Y, Muragaki Y, Iseki H
  • Organizer: The World Society for Stereotactic and Functional Neurosurgery (WSSFN)
  • Place of Presentation: Tokyo
• [Presentation] 脳腫瘍の未来予測手術-機能･構造に注目した診断と治療- (2013)
  • Author(s): 田村学、村垣善浩、丸山隆志、小西良幸、吉光喜太郎、鈴木孝司、生田聡子、岡本淳、 仁木千晴、岡田芳和、伊関
  • Organizer: 第13回日本術中画像情報学会
  • Place of Presentation: 山形
• [Presentation] 脳神経外科手術を予想するMRIの脳溝イメージング (2013)
  • Author(s): 田村学、丸山隆志、村垣善浩、齋藤太一、吉光喜太郎、生田聡子、小西良幸、岡本淳、鈴木孝司、仁木千晴、Jean-Francois Mangin、Jean Regis、Mikhail Chernov、岡田芳和、伊関洋
  • Organizer: 第22回日本コンピュータ外科学会
  • Place of Presentation: 東京
• [Presentation] Performance Evaluation of Default Module for Interactive Tractography Seeding (2013)
  • Author(s): Tamura M, Konishi Y, Suzuki T
  • Organizer: MICCAI 2013 DTI Tractography Challenge
  • Place of Presentation: Nagoya
• [Presentation] Role of preoperative functional MRI in surgical management of gliomas (2012)
  • Author(s): Tamura M, Maruyama T, Muragaki Y, Kinno R, Sakai K, Yoshimitsu K, Ikuta S, Okamoto J, Suzuki T, Niki C, Saito T, Okada Y, Iseki H.
  • Organizer: The third Russian-Japanese Neurosurgical Symposium
  • Place of Presentation: Novosibirsk, Russia
  • Invited
• [Presentation] MRIからの脳溝イメージング情報を活用した脳外科手術 (2012)
  • Author(s): 田村学、丸山隆志、村垣善浩、斎藤太一、吉光喜太郎、生田聡子、岡本淳、鈴木孝司、 仁木千晴、Jean-Francois Mangin、Jean Regis、Mikhail Chernov、岡田芳和、伊関洋
  • Organizer: 第71回日本脳神経外科学会総会
  • Place of Presentation: 大阪