| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Outline of Final Research Achievements |
We tried to explore the appropriate transient middle cerebral artery occlusion model with type 2 diabetic rats. We tried to compare the 90 min occlusion of middle cerebral artery, together with the common carotid artery for 15min, 30min, and 45 min, individually. Ninety min occlusion of middle artery occlusion with 15 min common carotid artery occlusion model was appeared to be best in our condition. We also explore the brain protective mechanisms of valpronic acid, and explored the combination effects with bone marrow mononuclear cell transplantation therapy, from the points of view of anti-apoptotic, anti-oxidative damage, and anti- inflammatory effects.
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