| Project/Area Number |
24592148
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Meiji University of Integrative Medicine |
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Principal Investigator |
HIGUCHI Toshihiro 明治国際医療大学, 医学教育研究センター, 教授 (80218700)
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| Co-Investigator(Kenkyū-buntansha) |
TANAKA Chuzo 明治国際医療大学, 医学教育研究センター, 名誉教授 (80163541)
UMEDA Masahiro 明治国際医療大学, 医学教育研究センター, 教授 (60223608)
WATANABE Yasuharu 明治国際医療大学, 医学教育研究センター, 講師 (90454537)
KAWAI Yuko 明治国際医療大学, 医学教育研究センター, 助教 (90555616)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | MRS / 代謝 / 内在性神経細胞 / 神経再生 / neurogenesis / GABA |
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| Outline of Final Research Achievements |
Proton magnetic resonance spectroscopy (1H-MRS) has been widely used for detection of metabolites that are specific for tissues and these compounds have been used as reliable biomarkers. The purpose of these studies is to detect the "neurogenesis imaging" technique using 1H-MRS signal, and propose the clinical application. The 1.28-ppm chemical shift correlates with neurogenesis and suggest that can be analyzed using the 1.28-ppm biomarker as a valid reference for NPCs. We found the NPCs specific spectra at 1.28ppm in the human brain using 3.0-T MRI.
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