The new neurogenesis imaging for the development of in vivo clinical applications

• Project/Area Number: 24592148
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cerebral neurosurgery
• Research Institution: Meiji University of Integrative Medicine
• Principal Investigator: HIGUCHI Toshihiro 明治国際医療大学, 医学教育研究センター, 教授 (80218700)
• Co-Investigator(Kenkyū-buntansha): TANAKA Chuzo 明治国際医療大学, 医学教育研究センター, 名誉教授 (80163541) ; UMEDA Masahiro 明治国際医療大学, 医学教育研究センター, 教授 (60223608) ; WATANABE Yasuharu 明治国際医療大学, 医学教育研究センター, 講師 (90454537) ; KAWAI Yuko 明治国際医療大学, 医学教育研究センター, 助教 (90555616)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: MRS / 代謝 / 内在性神経細胞 / 神経再生 / neurogenesis / GABA

Outline of Final Research Achievements

Proton magnetic resonance spectroscopy (1H-MRS) has been widely used for detection of metabolites that are specific for tissues and these compounds have been used as reliable biomarkers. The purpose of these studies is to detect the "neurogenesis imaging" technique using 1H-MRS signal, and propose the clinical application. The 1.28-ppm chemical shift correlates with neurogenesis and suggest that can be analyzed using the 1.28-ppm biomarker as a valid reference for NPCs. We found the NPCs specific spectra at 1.28ppm in the human brain using 3.0-T MRI.

Research Products

• [Journal Article] Diffusion-weighted Line-scan Echo-planar Spectroscopic Imaging Technique to Reduce Motion Artifacts in Metabolite Diffusion Imaging (2015)
  • Author(s): Bito Y, Hirata K, Ebisu T, Kawai Y, Otake Y, Hirata S, Shirai, T, Soutome Y, Ochi H, Yamamoto E, Umeda M, Higuchi T, Tanaka C
  • Journal Title: Magnetic Resonance in Medical Sciences Volume: 14 Issue: 1 Pages: 43-50
  • DOI: 10.2463/mrms.2014-0024
  • NAID: 130004700397
  • ISSN: 1347-3182, 1880-2206
  • Peer Reviewed / Open Access
• [Journal Article] Activity in early visual areas predicts interindividual differences in binocular rivalry dynamics. (2014)
  • Author(s): Yamashiro, H., Yamamoto, H., Mano, H., Umeda M., Higuchi, T., & Saiki, J.
  • Journal Title: Journal of Neurophysiology Volume: 111 Issue: 6 Pages: 1090-1202
  • DOI: 10.1152/jn.00509.2013
  • NAID: 120005458271
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] fMRIによる AKA-博田法の検討－第２報ー慢性腰痛の治療前後の副運動２型刺激による脳賦活領域の変化ー (2014)
  • Author(s): 田中忠蔵、村瀬智一、福永雅喜、博田節夫、梅田雅宏、河合裕子、渡邉康晴、樋口敏宏
  • Journal Title: 日本関節運動学的アプローチ医学会誌 Volume: 15 Pages: 53-58
  • Peer Reviewed
• [Journal Article] Deconvolution Analyses with Tent Functions Reveal Delayed and Long-sustained Increases of BOLD Signals with Acupuncture Stimulation (2013)
  • Author(s): Murase T, Umeda M, Fukunaga M, Tanaka C, Higuchi T
  • Journal Title: Magnetic Resonance in Medical Sciences Volume: 12 Issue: 2 Pages: 121-127
  • DOI: 10.2463/mrms.2012-0070
  • NAID: 10031183925
  • ISSN: 1347-3182, 1880-2206
  • Peer Reviewed
• [Journal Article] Relationship Between Preoperative Magnetic Resonance Imaging and Surgical Findings: Aneurysm Wall Thickness on High-Resolution T₁-Weighted Imaging and Contact With Surrounding Tissue on Steady-State Free Precession Imaging (2013)
  • Author(s): Tenjin H, Tanigawa S, Takadou M, Ogawa T, Mandai A, Nanto M, Osaka Y, Nakahara Y, Umeda M, Higuchi T.
  • Journal Title: Neurologia medico-chirurgica Volume: 53 Issue: 5 Pages: 336-342
  • DOI: 10.2176/nmc.53.336
  • NAID: 10031158762
  • ISSN: 0470-8105, 1349-8029
  • Peer Reviewed
• [Journal Article] 高照度照明が大脳視覚過程に及ぼす影響：脳機能イメージング研究. (2013)
  • Author(s): 川島康裕, 山城博幸, 山本洋紀, 村瀬智一, 市村好克, 梅田雅宏, 樋口敏宏
  • Journal Title: 照明学会誌 Volume: 98 Pages: 87-92
  • NAID: 120005606116
  • Peer Reviewed
• [Journal Article] 独立性成分分析法を用いた鍼刺激後も持続する脳機能 MRIの解析. (2013)
  • Author(s): 村瀬 智一, 樋口敏宏
  • Journal Title: 明治国際医療大学誌 Volume: 8 Pages: 13-22
  • NAID: 110009595897
  • Peer Reviewed
• [Journal Article] Inconsistency and uncertainty of the human visual area loci following surface-based registration : probability and entropy maps (2012)
  • Author(s): Yamamoto H, Fukunaga M, Takahashi S, Mano H, Tanaka C, Umeda M, Ejima Y
  • Journal Title: Human Brain Mappinng Volume: Vol.33 Issue: 1 Pages: 121-129
  • DOI: 10.1002/hbm.21200
  • NAID: 120003692413
  • URL: http://hdl.handle.net/2433/152357.
  • Peer Reviewed
• [Presentation] ヒト脳内のGABA測定条件に関する検討 (2015)
  • Author(s): 村瀬智一、梅田雅宏、渡邉康晴、樋口敏宏
  • Organizer: 臨床MR脳機能研究会
  • Place of Presentation: 東京都
  • Year and Date: 2015-03-14
• [Presentation] Multiple neural processes underlying binocular rivalry in retinotopic visual (2014)
  • Author(s): Yamashiro H, Yamatomo H, Mano H, Umeda M, Higuchi T, Saiki J
  • Organizer: Society for Neuroscience
  • Place of Presentation: Washington, DC
  • Year and Date: 2014-11-15 – 2014-11-19
• [Presentation] 肥満は筋のeigenvaluesを低下させる (2014)
  • Author(s): 渡邉康晴、木村啓作、梅田雅宏、河合裕子、村瀬智一、樋口敏宏
  • Organizer: 日本磁気共鳴医学会大会
  • Place of Presentation: 京都府
  • Year and Date: 2014-09-18 – 2014-09-20
• [Presentation] locomotive syndromeを視野に入れた筋のコンディション評価法 (2014)
  • Author(s): 木村啓作、渡邉康晴、梅田雅宏、樋口敏宏
  • Organizer: 日本磁気共鳴医学会大会
  • Place of Presentation: 京都府
  • Year and Date: 2014-09-18 – 2014-09-20
• [Presentation] 仮想灸刺激に伴う脳活動変化の検討 (2014)
  • Author(s): 村瀬智一、梅田雅宏、福永雅喜、渡邉康晴、樋口敏宏
  • Organizer: 日本磁気共鳴医学会大会
  • Place of Presentation: 京都府
  • Year and Date: 2014-09-18 – 2014-09-20
• [Presentation] 呼吸に伴う腎臓の位置変化と腰部刺鍼の検討-3次元MRIによる評価- (2014)
  • Author(s): 村瀬智一、梅田雅宏、新原寿志、渡邉康晴、樋口敏宏
  • Organizer: 全日本鍼灸学会学術大会
  • Place of Presentation: 愛媛県
  • Year and Date: 2014-05-16 – 2014-05-18
• [Presentation] Validation of the Temporal Signal Change Caused by Acupuncture Stimulation with Multi-Band Acquisition (2014)
  • Author(s): Murase T, Umeda M, Fukunaga M, Maruyama K, Kawai Y, Watanabe Y, Tanaka C, Highchi T
  • Organizer: International Society for Magnetic Resonance in Medicine
  • Place of Presentation: Milano
  • Year and Date: 2014-05-10 – 2014-05-16
• [Presentation] Brain Activation Study by Passive Intra-Articular Movement of Radiolunate and Sacroiliac Joints Using fMRI. (2013)
  • Author(s): Tanaka Chuzo, Hakata Setsuo, Murase Tomokazu, Umeda Masahiro, Watanabe Yasuharu, Kawai Yuko, Someya Yoshiaki, Naruse Shoji, Higuchi Toshihiro
  • Organizer: International Society for Magnetic Resonance in Medicine 21st Annual Meeting & Exhibition
  • Place of Presentation: Salt Lake City
• [Presentation] Deconvolution Analyses with Tent Functions Reveal Delayed and Long-Sustained Increases of BOLD Signals with Acupuncture Stimulation. (2013)
  • Author(s): Murase Tomokazu, Umeda Masahiro, Kawai Yuko, Watanabe Yasuharu, Naruse Shoji, Tanaka Chuzo, Highchi Toshihiro
  • Organizer: International Society for Magnetic Resonance in Medicine 21st Annual Meeting & Exhibition
  • Place of Presentation: Salt Lake City
• [Presentation] Diffusion Tensor Spectroscopic Imaging of Multiple Metabolites in Rat Brains. (2013)
  • Author(s): Bito Yoshitaka, Kawai Yuko, Hirata Koji, Ebisu Toshihiko, Otake Yosuke, Hirata Satosh, Shirai Toru, Soutome Yoshihisa, Ochi Hisaaki, Umeda Masahiro, Higuchi Toshihiro, Tanaka, Chuzo
  • Organizer: International Society for Magnetic Resonance in Medicine 21st Annual Meeting & Exhibition
  • Place of Presentation: Salt Lake City
• [Presentation] Visualization of Hysteresis in Passive Time-Dependent Responses of Skeletal Muscle in vivo by Using DTI. (2013)
  • Author(s): Watanabe Yasuharu, Kimura Keisaku, Umeda Masahiro, Kawai Yuko, Murase Tomokazu, Higuchi Toshihiro, Tanaka Chuzo, Naruse Shoji
  • Organizer: International Society for Magnetic Resonance in Medicine 21st Annual Meeting & Exhibition
  • Place of Presentation: Salt Lake City
• [Presentation] 照明強度のヒト大脳視覚野活動への影響：fMRI研究. (2013)
  • Author(s): 川島康裕, 山城博幸, 山本洋紀, 村瀬智一, 市村好克, 梅田雅宏, 樋口敏宏
  • Organizer: 第46回照明学会全国大会
  • Place of Presentation: 名古屋市
• [Presentation] 加圧運動負荷による水分子の動態評価 –加圧運動後と加圧解放安静時の評価 (2013)
  • Author(s): 木村啓作, 渡邉康晴, 梅田雅宏, 樋口敏宏
  • Organizer: 第68回日本体力医学会大会
  • Place of Presentation: 東京
• [Presentation] 磁性イオン液体を用いた局所シム調整の試み. (2013)
  • Author(s): 梅田雅宏, 渡邉康晴, 河合裕子, 村瀬智一, 田中忠蔵, 樋口敏宏
  • Organizer: 第41回日本磁気共鳴医学会大会
  • Place of Presentation: 徳島市
• [Presentation] Deconvolution 解析を用いた鍼刺激に伴う賦活領域毎の経時変化の検討. (2013)
  • Author(s): 村瀬智一, 梅田雅宏, 福永雅喜, 河合裕子, 渡邉康晴, 田中忠蔵, 樋口敏宏
  • Organizer: 第41回日本磁気共鳴医学会大会
  • Place of Presentation: 徳島市
• [Presentation] MEGA-PRESS 法による異なる視覚野間の GABA 計測の検討. (2013)
  • Author(s): 村瀬智一, 梅田雅宏, 山城博幸, 山本洋紀, 河合裕子, 田中忠蔵, 樋口敏宏
  • Organizer: 第41回日本磁気共鳴医学会大会
  • Place of Presentation: 徳島市
• [Presentation] 1H-MRSI を用いた骨格筋中アセチル -L- カルニチン濃度の運動による変化. (2013)
  • Author(s): 梅田雅宏, 渡邉康晴, 河合裕子, 村瀬智一, 田中忠蔵, 樋口敏宏
  • Organizer: 第41回日本磁気共鳴医学会大会
  • Place of Presentation: 徳島市
• [Presentation] Diffusion-weighted Spectroscopic Imaging を用いた脳虚血モデルラットにおける 複数代謝物 ADC の解析 (2013)
  • Author(s): 尾藤良孝, 河合裕子, 平田宏司, 恵飛須俊彦, 大竹陽介, 平田智嗣, 白猪 亨, 五月女悦久, 越智久晃, 梅田雅宏, 樋口敏宏, 田中忠蔵
  • Organizer: 第41回日本磁気共鳴医学会大会
  • Place of Presentation: 徳島市
• [Presentation] The visualization of muscle contracting region using electrical stimulation -comparison between LFEA and percutaneous electrical stimulation. (2013)
  • Author(s): Y. Watanabe, K. Kimura, M. Umeda, Y. Kawai, T. Higuchi
  • Organizer: 5th GUNTM International Symposium 2013
  • Place of Presentation: Kyoto
• [Presentation] Deconvolution Analyses with Tent Functions Reveal Delayed and Long-Sustained Increases of BOLD Signals with Acupuncture Stimulation. (2013)
  • Author(s): Tomokazu Murase, Masahiro Umeda, Yuko Kawai, Yasuharu Watanabe, Toshihiro Higuchi, Chuzo Tanaka
  • Organizer: 5th GUNTM International Symposium 2013
  • Place of Presentation: Kyoto
• [Presentation] Brain Activation Study by Passive Intra-Articular Movement of Radiolunate and Sacroiliac Joints Using fMRI. (2013)
  • Author(s): Tanaka Chuzo, Hakata Setsuo, Murase Tomokazu, Umeda Masahiro, Watanabe Yasuharu, Kawai Yuko, Someya Yoshiaki, Naruse Shoji, Higuchi Toshihiro
  • Organizer: International Society for Magnetic Resonance in Medicine 21th Annual Meeting & Exhibition
  • Place of Presentation: ソルトレイクシティ
• [Presentation] Deconvolution Analyses with Tent Functions Reveal Delayed and Long-Sustained Increases of BOLD Signals with Acupuncture Stimulation (2013)
  • Author(s): Murase Tomokazu, Umeda Masahiro, Kawai Yuko, Watanabe Yasuharu, Naruse Shoji, Tanaka Chuzo, Highchi Toshihiro
  • Organizer: International Society for Magnetic Resonance in Medicine 21th Annual Meeting & Exhibition
  • Place of Presentation: ソルトレイクシティ
• [Presentation] Diffusion Tensor Spectroscopic Imaging of Multiple Metabolites in Rat Brains (2013)
  • Author(s): Bito Yoshitaka, Kawai Yuko, Hirata Koji, Ebisu Toshihiko, Otake Yosuke, Hirata Satosh, Shirai Toru, Soutome Yoshihisa, Ochi Hisaaki, Umeda Masahiro, Higuchi Toshihiro, Tanak, Chuzo
  • Organizer: International Society for Magnetic Resonance in Medicine 21th Annual Meeting & Exhibition
  • Place of Presentation: ソルトレイクシティ
• [Presentation] Visualization of Hysteresis in Passive Time-Dependent Responses of Skeletal Muscle in vivo by Using DTI (2013)
  • Author(s): Watanabe Yasuharu, Kimura Keisaku, Umeda Masahiro, Kawai Yuko, Murase Tomokazu, Higuchi Toshihiro, Tanaka Chuzo, Naruse Shoji
  • Organizer: International Society for Magnetic Resonance in Medicine 21th Annual Meeting & Exhibition
  • Place of Presentation: ソルトレイクシティ
• [Presentation] Detection of Spontaneous Pain due to Chronic Pain in the Rat (2012)
  • Author(s): Yuko Kawai,Masahiro Umeda,Yasuharu Watanabe,Toshihiro Higuchi,Chuzo Tanaka
  • Organizer: International Society for Magnetic Resonance in Medicine 20th Annual Meeting & Exhibition
  • Place of Presentation: メルボルン
• [Presentation] Diffusion-weighted Spectroscopic Imaging of Multiple Metabolites in Rat Brains after Middle Cerebral Artery Occlusion (2012)
  • Author(s): Yoshitaka Bito,Yuko Kawa,Koji Hirata, Toshihiko Ebisu,Yosuke Otake,Satoshi Hirata, Toru Shirai,Yoshihisa Soutome,Hisaaki Ochi, Masahiro Umeda,Toshihiro Higuchi,Chuzo Tanaka
  • Organizer: International Society for Magnetic Resonance in Medicine 20th Annual Meeting & Exhibition
  • Place of Presentation: メルボルン
• [Presentation] Investigating the duration of brain response to acupuncture stimulation by using independent component analysis (2012)
  • Author(s): Tomokazu Murase,Masahiro Umeda,Yuko Kawai,Yasuharu Watanabe,Toshihiro Higuchi, Chuzo Tanaka
  • Organizer: International Society for Magnetic Resonance in Medicine 20th Annual Meeting & Exhibition
  • Place of Presentation: メルボルン
• [Presentation] The investigation of apparent diffusion coefficient in renal cortex and medulla during the cardiac cycle (2012)
  • Author(s): Masahiro Umeda,Toshihiro Higuchi,Yuki Mori, Yoshichika Yoshioka,Yasuharu Watanabe,Yuko Kawai,Tomokazu Murase,Chuzo Tanaka
  • Organizer: International Society for Magnetic Resonance in Medicine 20th Annual Meeting & Exhibition
  • Place of Presentation: メルボルン
• [Presentation] MRI測定に用いる熱刺激システムの試作と性能検証 (2012)
  • Author(s): 村瀬智一,梅田雅宏,河合裕子,渡邉康晴,樋口 敏宏,田中忠蔵
  • Organizer: 第40回日本磁気共鳴医学会大会
  • Place of Presentation: 京都
• [Presentation] Low bを用いた拡散強調画像による心筋の収縮および拡張評価 (2012)
  • Author(s): 梅田雅宏,樋口敏宏,渡邉康晴,河合裕子,村瀬 智一,関本達之,大門律雄,村松佑哉
  • Organizer: 第40回日本磁気共鳴医学会大会
  • Place of Presentation: 京都
• [Presentation] DWIを用いた筋組織の圧変形とその回復過程の画像化 (2012)
  • Author(s): 渡邉康晴,木村啓作,梅田雅宏,河合裕子,樋口 敏宏,田中忠蔵
  • Organizer: 第40回日本磁気共鳴医学会大会
  • Place of Presentation: 京都
• [Presentation] 健常ラット脳のDiffusion Tensor Spectroscopic Imaging (DTSI) (2012)
  • Author(s): 尾藤良孝,河合裕子,平田宏司,恵飛須俊彦,大 竹陽介,平田智嗣,白猪亨,五月女悦久,越智久 晃,梅田雅宏,樋口敏宏,田中忠蔵
  • Organizer: 第40回日本磁気共鳴医学会大会
  • Place of Presentation: 京都
• [Presentation] 照明強度のヒト大脳視覚野活動への影響:fMRI研究 (2012)
  • Author(s): 川島康裕, 山城博幸, 山本洋紀, 村瀬智一, 市村 好 克, 梅田雅宏, 樋口敏宏
  • Organizer: 平成24年度照明学会全国大会
  • Place of Presentation: 山口