| Project/Area Number |
24592149
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Kawasaki Medical School |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KIMURA Kazumi 日本医科大学, 医学(系)研究科(研究院), 教授 (00388927)
INOUE Takeshi 川崎医科大学, 医学部, 准教授 (80388941)
UNO Masaaki 川崎医科大学, 医学部, 教授 (90232884)
IGUCHI Yasuyuki 東京慈恵会医科大学, 医学部, 教授 (30287198)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Keywords | 頸動脈プラーク / 頸部血管エコー / 超音波造影剤 / 内頚動脈内膜剥離術 / 病理学的所見 / 新生血管 / 不安定プラーク / 造影頸部血管エコー / 内頸動脈内膜剥離術 / 虚血性脳血管障害 / 頸動脈内膜剥離術 |
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| Outline of Final Research Achievements |
The aim of the present study was to investigate the histopathologic findings of enhanced carotid plaque on CEUS. CEUS revealed enhanced plaque in 45 (61.1%) of 54 patients enrolled in the study. Enhanced plaque was classified into two subgroups: a spotty pattern as moving bright spots within plaque; and a linear pattern, where enhanced lesions appeared as a line from intima into plaque. The amount of neovascularization was larger in enhanced than in non-enhanced plaque (6.31±6.83/2.5mm2 vs. 1.37±1.55/2.5mm2, P=0.002). Furthermore, the enhanced group had more macrophage aggregation (8.16±8.97% vs. 4.42±1.48%, P=0.011) compared with the non-enhanced group. 86.4% of the enhanced plaques with a linear pattern had fibrous cap rupture, but this was observed in only 20% of those with a spotty pattern (P<0.0001). Enhanced plaque on CEUS should become a new surrogate marker of vulnerable carotid plaque.
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