| Project/Area Number |
24592150
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | National Cardiovascular Center Research Institute |
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Principal Investigator |
KATAOKA HIROHARU 独立行政法人国立循環器病研究センター, 病院, 医長 (40359815)
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| Co-Investigator(Kenkyū-buntansha) |
YAGI Takanobu 早稲田大学, 理工学術院, 講師 (00468852)
NAKAMURA Masanori 埼玉大学, 理工学研究科, 准教授 (20448046)
SAITO Kozue 独立行政法人国立循環器病研究センター, 病院, 医師 (80398429)
UMEZU Mitsuo 早稲田大学, 理工学術院, 教授 (90132927)
IIHARA Koji 九州大学, 医学(系)研究科(研究院), 教授 (90270727)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 脳動脈瘤 / PC-MRI / 数値流体解析 / CFD / バイパス術 |
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| Outline of Final Research Achievements |
This study aimed at the prediction of cerebral hemodynamics after revascularization surgery for complex intracranial aneurysms by using phase contrast magnetic resonance imaging (PC-MRI) and computational fluid dynamics (CFD), thus developing a treatment support tool leading to the improvement of operative outcomes. First, we optimezed acquisition parameters of PC-MRI using a silicone model and normal volunteers, and then measured pre and post-operative blood flow in cerebral arteies of patients with an intracranial aneurysm undergoing a revascularzation surgery using optimezed parameters. Blood flow, vessel diameters and wall shear stress (WSS)dynamically changed immediate after surgery, and WSS tended to retrun to the preoperative value after three months. These results revealed one of the rules determinating hemodynamics after revascularization surgery for complex intracranial aneurysms.
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