| Project/Area Number |
24592156
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | University of Yamanashi |
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Principal Investigator |
SATO Hiroki 山梨大学, 総合研究部, 助教 (50596997)
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| Co-Investigator(Kenkyū-buntansha) |
KAWATAKI Tomoyuki 山梨大学, 総合研究部, 講師 (20303406)
OZAKI Yukio 山梨大学, 総合研究部, 教授 (30134539)
INOUE Osamu 山梨大学, 総合研究部, 准教授 (00432154)
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| Co-Investigator(Renkei-kenkyūsha) |
INOUE Katsue 山梨大学, 総合研究部, 准教授 (10324211)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | CLEC-2 / グリオーマ / ポドプラニン |
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| Outline of Final Research Achievements |
This study was aimed to elucidate the role of CLEC-2 in the cell migration and proliferation capabilities of glioma. Using the human glioma cell lines, we examined the Scratch wound healing assay and Cell migration assay. In addition, subcutaneously transplanted with human glioma cells to CLEC-2 knockdown nude mouse group and the control nude mouse group, and the changes in the tumor volume were evaluated.
As as result, it was concluded that there was no obvious relationship between the invasion and proliferation and the function of the CLEC-2 in glioma cell lines.
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