Effects of parameters of the Deep brain stimulation on the therapeutic efficacy in MPTP treated monkey, a PET study
| Project/Area Number |
24592157
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Hamamatsu University School of Medicine |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SUGIYAMA Kenji 浜松医科大学, 医学部, 准教授 (00235904)
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| Co-Investigator(Renkei-kenkyūsha) |
NAMBA Hiroki 浜松医科大学, 医学部, 教授 (60198405)
ONOE Hirotaka 独立行政法人理化学研究所, 分子イメージング科学研究センター, チームリーダー (80214196)
OUCHI Yashuomi 浜松医科大学, 医学部, 教授 (40436978)
MAGATA Yashuhiro 浜松医科大学, 医学部, 教授 (20209399)
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | パーキンソン氏病 / サルモデル / 脳深部電気刺激術 / 視床下核 / PET / 分子イメージング研究 / MPTPサルモデル / 脳深部電気刺激 / 分子イメージング / MPTP全身投与サルモデル |
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| Outline of Final Research Achievements |
The present study investigated the difference of efficacy and brain activated areas by different frequencies (30Hz、145Hz) during deep brain stimulation (DBS)of subthalamic nucleus (STN) in Parkinson’s disease (PD) monkey model. We performed H215O-PET to investigate the cerebral blood flow affected by “effective” (145 Hz) and “ineffective (30Hz) DBS when the behavioral test was performing. During the experiments, we developed the new PD model, new fixing device and the new behavioral tests. During the PET study, our preliminary data firstly showed that unilateral effective DBS may activate bilateral premotor areas, which means effective STN-DBS ameliorates not only the motor impairments, but also the preparation and initiation of the bilateral motor in PD state. This finding is helpful to achieve a deeper insight as to the mechanisms of DBS.
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Report
(5 results)
Research Products
(17 results)
