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Role of synaptic vesicle 2A protein to obtain epileptogenesis through neurogenesis in hippocampus

Research Project

Project/Area Number 24592173
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Cerebral neurosurgery
Research InstitutionJuntendo University

Principal Investigator

SUGANO Hidenori  順天堂大学, 医学部, 准教授 (90265992)

Co-Investigator(Kenkyū-buntansha) NAKAJIMA Madoka  順天堂大学, 医学部, 准教授 (50317450)
ARAI Hajime  順天堂大学, 医学部, 教授 (70167229)
NISHIMURA Kinya  順天堂大学, 医学部, 教授 (80164581)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords神経細胞新生 / 海馬 / てんかん / SV2A / 神経新生 / パッチクランプ / Levetiracetam / levetiracetam
Outline of Final Research Achievements

We investigate our hypothesis that inhibition of SV2A can stabilize the neurogenesis and consequently prevent the epileptogenesis. We evaluated an appearance and electrical characteristics of newborn cells in the hippocampus after initial seizure insult in this study. We counted and observed its morphology of newborn cells among Levetiracetam (LEV) (SV2A stabilizer) treatment and non-treatment groups. The number of newborn neurons in the LEV group was significantly less than that of the non-treatment group. Furthermore, LEV made normalized the cell appearance. In the results of patch-clump method, early appeared newborn neurons were immature with easily excitable characteristics, however survived neuron for 28 days from initial seizure insult showed the same electrical characteristics as that of matured neuron. From these results, stabilization of SV2A after an initial incentive has a possibility to prevent inducing epileptogenicity through neurogenesis.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (14 results)

All 2015 2014 2013 2012 Other

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (10 results) Remarks (1 results)

  • [Journal Article] Posterior quadrant disconnection surgery for Sturge-Weber syndrome.2014

    • Author(s)
      Sugano H, Nakanishi H, Nakajima M, Higo T, Iimura Y, Tanaka K, Hosozawa M, Niijima S, Arai H
    • Journal Title

      Epilepsia

      Volume: In Press Issue: 5 Pages: 683-9

    • DOI

      10.1111/epi.12547

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sturge–Weber syndrome with spontaneous intracerebral hemorrhage in childhood.2014

    • Author(s)
      M Nakajima, H Sugano, Y Iimura, T Higo, H Nakanishi, K Shimoji, K Karagiozov, M Miyajima, H Arai
    • Journal Title

      Neurosurg Pediatr.

      Volume: 13(1) Issue: 1 Pages: 90-93

    • DOI

      10.3171/2013.9.peds133

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The somatic GNAQ mutation c.548G>A (p.R183Q) is consistently found in Sturge-Weber syndrome.2014

    • Author(s)
      Nakashima M, Miyajima M, Sugano H, Iimura Y, Kato M, Tsurusaki Y, Miyake N, Saitus H, Arai H, Matsumoto N.
    • Journal Title

      J Hum Genet.

      Volume: 59 Issue: 12 Pages: 691-3

    • DOI

      10.1038/jhg.2014.95

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Presentation] Levetiracetamの予防的投与がてんかんモデルマウスの海馬歯状回におよぼす影響について2015

    • Author(s)
      菅野秀宣、肥後拓磨、中島円、飯村康司、新井一
    • Organizer
      第48回日本てんかん学会年次学術集会
    • Place of Presentation
      東京、京王プラザホテル
    • Year and Date
      2015-10-02 – 2015-10-03
    • Related Report
      2014 Annual Research Report
  • [Presentation] レベチラセタムが側頭葉てんかんモデルマウスの海馬歯状回における病理学変化に与える影響について2015

    • Author(s)
      菅野秀宣、肥後拓磨、中島円、飯村康司、新井一
    • Organizer
      第38回日本てんかん外科学会
    • Place of Presentation
      東京、都市センターホテル
    • Year and Date
      2015-01-15 – 2015-01-16
    • Related Report
      2014 Annual Research Report
  • [Presentation] Preventive effect of Levetiracetam against the pathological changes in hippocampus of temporal lobe epilepsy model mice2014

    • Author(s)
      Sugano H, Higo T, Nakajima M, Iimura Y, Arai H
    • Organizer
      68th Annual meeting of American Epilepsy society
    • Place of Presentation
      Seattle
    • Year and Date
      2014-12-08
    • Related Report
      2014 Annual Research Report
  • [Presentation] レベチラセタムが側頭葉てんかんモデルマウスの海馬歯状回における病理学変化に与える影響について2014

    • Author(s)
      菅野秀宣、肥後拓磨、中島円、飯村康司、新井一
    • Organizer
      第73回 日本脳神経外科学会学術総会
    • Place of Presentation
      東京、グランドプリンスホテル新高輪
    • Year and Date
      2014-10-09 – 2014-10-11
    • Related Report
      2014 Annual Research Report
  • [Presentation] てんかん重積によるマウス海馬歯状回の病理的変化に対するレベチラセタムの抑制作用について2014

    • Author(s)
      菅野秀宣、中島円、新井一
    • Organizer
      第37回日本てんかん外科学会
    • Place of Presentation
      大阪
    • Related Report
      2013 Research-status Report
  • [Presentation] Preventive effect of Levetiracetam against the pathological changes in hippocampus of temporal lobe epilepsy model mice2013

    • Author(s)
      Sugano H, Nakajima M, Arai H
    • Organizer
      2013 international epilepsy congress
    • Place of Presentation
      Montreal, Canada
    • Related Report
      2013 Research-status Report
  • [Presentation] てんかんマウスにおける重積後の海馬歯状回の細胞新生とレベチラセタム投与による新生抑制作用2013

    • Author(s)
      菅野秀宣、中島円、新井一
    • Organizer
      第47回日本てんかん学会年次学術集会
    • Place of Presentation
      北九州
    • Related Report
      2013 Research-status Report
  • [Presentation] てんかんモデルマウスにおける重積後の海馬歯状回の細胞新生とレベチラセタム投与による新生抑制作用2013

    • Author(s)
      菅野秀宣、中島円、新井一
    • Organizer
      第73回 日本脳神経外科学会学術総会
    • Place of Presentation
      横浜
    • Related Report
      2013 Research-status Report
  • [Presentation] Preventive treatment with Levetiracetam against the pathological changes in hippocampus of temporal lobe epilepsy model mice2013

    • Author(s)
      菅野秀宣
    • Organizer
      30th international epilepsy congress
    • Place of Presentation
      Montreal, Canada
    • Related Report
      2012 Research-status Report
  • [Presentation] Levetiracetamの予防的投与によるてんかんモデルマウスの海馬歯状回の病理学的変化について2012

    • Author(s)
      菅野秀宣
    • Organizer
      第46回日本てんかん学会学術集会
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
  • [Remarks] 順天堂大学医学部付属順天堂医院 てんかんセンター

    • URL

      http://www.juntendo.ac.jp/hospital/epilepsy/

    • Related Report
      2014 Annual Research Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

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