| Project/Area Number |
24592175
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Nihon University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KOBAYASHI Kazutaka 日本大学, 医学部, 准教授 (20366579)
OSHIMA Hideki 日本大学, 医学部, 准教授 (20328735)
YAMAMOTO Takamitsu 日本大学, 医学部, 教授 (50158284)
KATAYAMA Yoichi 日本大学, 医学部, 教授 (00125048)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | パーキンソン病 / 脳深部刺激療法 / 視床下核 / ドーパミン / 抗パーキンソン病薬 / 体感幻覚 / うつ / ニューロモデュレーション / 早期手術 / 罹病期間 / 薬物療法 / 機能予後 / 認知機能 / 運動機能 / 情動 / 脳刺激療法 / L-ドパ / 精神症状 |
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| Outline of Final Research Achievements |
We studied the cenesthopathy-like symptom and depressive mood as the factors that affect the outcome of subthalamic nucleus- deep brain stimulation (STN-DBS) in Parkinson’s disease. As a result, a significant relationship between cenesthopathy-like symptom and preoperative L-dopa intake dose was found. From this result, we considered that this symptom is associated with L-dopa dysregulation syndrome.
The effect of preoperative depressive mood was also studied. The result of this study suggest that the prognosis of the patients with preoperative depressive mood were significantly worse 3 years after the surgery both in the on- (p<0.012) and off-periods (p<0.037). Moreover, the cognitive function of such patients at that time declined significantly (p<0.006).
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