| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Outline of Final Research Achievements |
The change in copy number, but not mutation, of PDGFRA was associated with radiation necrosis. We could not find other molecules which showed significant correlation with radiation necrosis, from the analyses by array-CGH, cDNA array, and next generation sequencing. On the other hand, the methylation status of MGMT gene promoter was significant risk factor for radiation injury, and tumors with methylated MGMT gene promoter had higher risk for necrosis. Tailor-made setting of irradiation doses (high-dose for MGMT unmethylated cases, and moderate-dose for methylated ones) had revealed that decrease of irradiation dose had contributed to prevent radiation injury, while keeping the same survival benefit of irradiation. These findings indicated the feasibility of tailor-made setting of treatment doses based upon the methylation status of MGMT gene promoter.
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