Examination of biomarker for brain metastases

• Project/Area Number: 24592180
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cerebral neurosurgery
• Research Institution: National Cancer Center Japan
• Principal Investigator: NARITA Yoshitaka 独立行政法人国立がん研究センター, 中央病院, 科長 (40392344)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 転移性脳腫瘍 / 放射線治療 / バイオマーカー / 予後因子 / Trastuzumab / MGMT / データベース / trastuzumab / がん / 脳腫瘍 / 乳癌 / HER2 / ハーセプチン

Outline of Final Research Achievements

Our aim of this study is to elucidate the prognostic factors and biomarkers of brain metastases. We established the multi-institutional database for brain metastases using UMIN/INDICE systems.
The expression of ER, PR and HER2 in pathology samples of 62 primary breast cancer and brain metastases were compared in order to evaluate alteration of these molecules. Differences in the immunohistochemical profiles of ER, PR or HER2 between the primary tumors and the brain metastases in about 30% were identified. Our results suggested that the HER2 status in brain metastases requires re-evaluation and extended trastuzumab therapy is recommended after brain metastases. We also reviewed a total of 264 surgical cases of brain metastases. Our data indicate that the postoperative RPA class and treatment strategy were associated with early death. Deterioration of patients by surgery should be avoided in the treatment of brain metastases.

Research Products

• [Journal Article] Expression and clinical significance of genes frequently mutated in small cell lung cancers defined by whole exome/RNA sequencing (2015)
  • Author(s): Iwakawa, R., Kohno, T., Totoki, Y., Shibata, T., Tsuchihara, K., Mimaki, S., Tsuta, K., Narita, Y., Nishikawa, R., Noguchi, M., Harris, C. C., Robles, A. I., Yamaguchi, R., Imoto, S., Miyano, S., Totsuka, H., Yoshida, T., Yokota, J.
  • Journal Title: Carcinogenesis Volume: 116 Issue: 6 Pages: 145-152
  • DOI: 10.1093/carcin/bgv026
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Trends and Outcomes in the Treatment of Gliomas Based on Data during 2001–2004 from the Brain Tumor Registry of Japan (2015)
  • Author(s): Narita, Y., Shibui, S.
  • Journal Title: Neurologia medico-chirurgica Volume: 55 Issue: 4 Pages: 286-295
  • DOI: 10.2176/nmc.ra.2014-0348
  • NAID: 130005065367
  • ISSN: 0470-8105, 1349-8029
• [Journal Article] Risk factors for early death after surgery in patients with brain metastases: reevaluation of the indications for and role of surgery (2014)
  • Author(s): Arita, H., Narita, Y., Miyakita, Y., Ohno, M., Sumi, M., Shibui, S.
  • Journal Title: J Neurooncol Volume: 116 Issue: 1 Pages: 145-152
  • DOI: 10.1007/s11060-013-1273-5
  • Peer Reviewed
• [Journal Article] Report of Brain Tumor Registry of Japan (2001-2004) (2014)
  • Author(s): Committee of Brain Tumor Registry of Japan
  • Journal Title: Neurol Med Chir (Tokyo) Volume: 54, Supplement 1 Pages: 1-102
• [Journal Article] Extended Trastuzumab Therapy Improves the Survival of HER-2–Positive Breast Cancer Patients After Surgery and Radiotherapy for Brain Metastases (2013)
  • Author(s): Okita Y, Narita Y, Shibui S, Maruno M, et al.
  • Journal Title: Molecular and Clinical Oncology Volume: in press Pages: 0-5
  • Peer Reviewed
• [Presentation] 転移性脳腫瘍の手術適応の再検討 －早期死亡例の解析から－ (2013)
  • Author(s): 有田英之、成田善孝、宮北康二、大野誠、野村昌志、渋井壮一郎
  • Organizer: 第51回日本癌治療学会学術集会
  • Place of Presentation: 国立京都国際会館
• [Presentation] 脳腫瘍全国集計調査2001-2004 にみる悪性脳腫瘍治療成績 (2013)
  • Author(s): 成田善孝
  • Organizer: 第31回日本脳腫瘍学会学術集会
  • Place of Presentation: 宮崎市
• [Presentation] 乳癌転移性脳腫瘍の臨床経過におけるtrastuzumabの役割について (2013)
  • Author(s): 沖田 典子、成田 善孝、渋井 壮一郎、丸野 元彦
  • Organizer: 第51回日本癌治療学会学術集会
  • Place of Presentation: 京都
• [Presentation] 転移性脳腫瘍に関する最近の知見
  • Author(s): 成田善孝
  • Organizer: 癌の中枢神経合併症フォーラム2013
  • Place of Presentation: 三島
• [Book] 転移性脳腫瘍 診断・治療・管理 (2014)
  • Author(s): 成田善孝 奥田武司 中川庸子
  • Total Pages: 160
  • Publisher: メディカ出版