| Project/Area Number |
24592187
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Chiba University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
OHTORI Seiji 千葉大学, 大学院医学研究院, 講師 (40361430)
INOUE Gen 北里大学, 医学部, 准教授 (80594209)
ORITA Sumihisa 千葉大学医学部付属病院, 材料部, 助教 (60638310)
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| Co-Investigator(Renkei-kenkyūsha) |
MIYAGI Masayuki 北里大学, 医学部, 助教 (90627556)
SUZUKI Miyako 千葉大学, 予防医学センター, 助教 (70734242)
TOYONE Tomoaki 帝京大学, 溝口病院整形外科, 教授 (10407918)
OZAWA Tomoyuki 帝京大学, 溝口病院整形外科, 講師 (60375706)
AOKI Yasuchika 千葉大学, 大学院医学研究院, 特任教授 (70584001)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 抗NGF療法 / CGRP / ラット尾椎椎間板圧迫モデル / 椎間板性腰痛 / 抗サイトカイン療法 / MIA / 変形性膝関節症 / 神経栄養因子 / 椎間板性疼痛 / 頸痛症 / 慢性運動器疼痛 / 神経成長因子 |
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| Outline of Final Research Achievements |
Create a rat caudal vertebrae intervertebral disc pressure model, we investigated the expression of calcitonin gene-related peptide (CGRP: neuropeptide involved in the inflammatory disease) in a cell body of dorsal root ganglia (DRG)to dominate the sensory nerve of the intervertebral disc. Intradiscal administration of the anti-NGF neutralizing antibodies suppressed the increased expression of CGRP of dominant sensory nerve (DRG). For the discogenic low back pain, anti-NGF therapy suggesting the potential to be effective .
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