| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
Imaging mass spectrometry was used to visualize twelve molecular species of phosphatidylcholine (PC) on thin slices of spinal cord with spinal cord injury (SCI). Unique distribution patterns were observed for phospholipids with different fatty acid compositions, and distinct dynamic changes were seen in both their amounts and their distributions in tissue as tissue damage resulting from SCI progressed. In particular, PCs containing docosahexaenoic acid localized to the large nucleus in the anterior horn region at one day post-SCI and rapidly decreased thereafter.
PC imaging revealed that the anti-IL-6 receptor antibody MR16-1 that has been shown to suppress inflammation after SCI was able to prevent the reduction of docosahexaenoic acid-containing PC in comparison with the control group at the injury site as early as 7 days post-SCI.
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