Clinical application of intervertebral disc repair: development of biological repair
| Project/Area Number |
24592193
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Mie University |
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Principal Investigator |
AKEDA Koji 三重大学, 医学部附属病院, 講師 (20422826)
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| Co-Investigator(Kenkyū-buntansha) |
MIYAMOTO Keiichi 三重大学, 工学(系)研究科(研究院), 准教授 (70252343)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 椎間板変性 / 組織再生 / 多血小板血漿 / 生体材料 / 椎間板性疼痛 / 成長因子 / 血小板 / 椎間板性腰痛 |
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| Outline of Final Research Achievements |
We report the results of a prospective feasibility clinical trial for the use of an intradiscal injection of PRP-releasate in patients with degenerative disc disease (discogenic low back pain). First, no adverse effects were identified following treatment. The intradiscal injection of PRP-releasate has potential to reduce clinical LBP scores in 85% subjects.
The results of this study showed that gellan-sulfate, candidate for disc biomaterial, has potential to affect the matrix metabolism of intervertebral disc cells dependent on the ratio of sulfation. In vivo animal study showed that gellan-sulfate has high tissue compatibility, suggesting the possibility that gellan-sulfate would be effective biomaterial for intervertebral disc degeneration.
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Report
(4 results)
Research Products
(48 results)
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[Journal Article] Extradural cryptococcoma at the sacral spine without bone involvement in an immunocompetent patient.2014
Author(s)
Asanuma Y, Fujimoto H, Nakabayashi H, Akeda K, Asanuma K, Tanaka M, Nagakura T, Miura Y, Iino T, Ogawa K, Kasai Y, Sudo A.
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Journal Title
J Orthop Sci
Volume: 印刷中
Issue: 6
Pages: 1040-1045
DOI
Related Report
Peer Reviewed
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[Journal Article] 脊椎椎体骨折の追跡コホート調査 既存骨骨折が新規骨折の発生様式に与える影響2014
Author(s)
明田 浩司, 加藤 俊宏, 松峯 昭彦, 長谷川 正裕, 若林 弘樹, 辻井 雅也, 淺沼 邦洋, 松原 孝夫, 西村 明展, 中村 知樹, 村田 耕一郎, 今西 隆夫, 森本 亮, 榊原 紀彦, 笠井 裕一, 須藤 啓広
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Journal Title
Source：Journal of Spine Research
Volume: 5(2)
Pages: 145-150
Related Report
Peer Reviewed
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[Presentation] Intradiscal Injection of Autologous Platelet-Rich-Plasma releasate for the Treatment of Discogenic Low Back Pain -Preliminary Prospective Clinical Trial of 12 cases-2013
Author(s)
K. Akeda, K. Murata, T. Imanishi, K. Ohishi, K. Masuda, A. Uchida, T. Sakakibara, Y. Kasai, A. Sudo
Organizer
Orthopaedic Research Society
Place of Presentation
San Antonio, TX, USA
Related Report
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