The pathomechanism of nociceptive pain and neuropathic pain in herniated disc disease

• Project/Area Number: 24592195
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Orthopaedic surgery
• Research Institution: Kobe University
• Principal Investigator: TAKADA Toru 神戸大学, 医学(系)研究科(研究院), 医学研究員 (00598526)
• Co-Investigator(Kenkyū-buntansha): NISHIDA Kotaro 神戸大学, 医学研究科, 講師 (00379372) ; KAKUTANI Kenichiro 神戸大学, 医学部附属病院, 助教 (10533739) ; MAENO Koichiro 神戸大学, 医学研究科, 助教 (70403269)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 椎間板変性 / 侵害受容性疼痛 / 神経障害性疼痛 / 変性 / 椎間板 / マクロファージ / なし

Outline of Final Research Achievements

We have previously shown that intervertebral disc and macrophages interaction induces pro-inflammatory reaction and pain related behavior. We clarified macrophages existence in degenerative disc not only in herniated disc disease but also lumbar canal stenosis. M1 macrophage, which plays inflammatory and tumoricidal activity, is exists in 95.5% of herniated disc disease and 95.6% of lumbar canal stenosis.

Research Products

• [Journal Article] A rat tail temporary static compression model reproduces different stages of intervertebral disc degeneration with decreased notochordal cell phenotype. (2014)
  • Author(s): Hirata H, Yurube T, Kakutani K, Maeno K, Takada T, Yamamoto J, Kurakawa T, Akisue T, Kuroda R, Kurosaka M, Nishida K.
  • Journal Title: J Orthop Res Volume: 32 Issue: 3 Pages: 455-63
  • DOI: 10.1002/jor.22533
  • Peer Reviewed / Acknowledgement Compliant
• [Presentation] M1 MACROPHAGE EXISTS IN THE DEGENERATIVE DISC (2014)
  • Author(s): T. Takada, K. Maeno, K. Kakutani, T. Yurube, H. Hirata, T. Kurakawa, S. Miyazaki, Y. Terashima, M Doita, M. Kurosaka, K. Nishida
  • Organizer: International Society for the study of Lumbar Spine
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2014-06-03 – 2014-06-07
• [Presentation] 脊椎変性疾患の変性椎間板にはM1マクロファージが存在する (2014)
  • Author(s): 高田 徹、前野 耕一郎、角谷 賢一朗、由留部 崇、平田 裕亮、蔵川 拓外、宮崎 真吾 寺嶋 良樹
  • Organizer: 第４３回脊椎脊髄病学会
  • Place of Presentation: 京都国際会館
  • Year and Date: 2014-04-17 – 2014-04-19
• [Presentation] 脊椎変性疾患の変性椎間板にはM1マクロファージが存在する (2014)
  • Author(s): 高田徹
  • Organizer: 第43回脊椎脊髄病学会
  • Place of Presentation: 京都 日本
• [Presentation] M1 MACROPHAGE EXISTS IN THE DEGENERATIVE DISC (2014)
  • Author(s): Toru Takada
  • Organizer: The International Society for he Study of the Lumbar Spine
  • Place of Presentation: ソウル 韓国
• [Presentation] 非ヘルニア変性椎間板には古典的活性化(M1)マクロファージが存在する (2013)
  • Author(s): 高田徹、前野耕一郎、角谷賢一朗、張 鍾穎、由留部 崇、山本潤哉、平田裕亮、蔵川拓外、宮崎真吾、土井田 稔、黒坂 昌弘、西田 康太郎
  • Organizer: 第42回脊椎脊髄病学会
  • Place of Presentation: 沖縄 コンベンションセンター
• [Presentation] M1 MACROPHAGE EXISTS IN THE NON-HERNIATED DEGENERATIVE DISC. (2013)
  • Author(s): T. Takada, K. Maeno, K. Kakutani, T. Yurube, J. Yamamoto, H. Hirata, T. Kurakawa, S. Miyazaki, M. Kurosaka, K. Nishida
  • Organizer: 2013 The International Society for Study of the Lumbar Spine
  • Place of Presentation: Scottsdale USA