| Project/Area Number |
24592195
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Kobe University |
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Principal Investigator |
TAKADA Toru 神戸大学, 医学(系)研究科(研究院), 医学研究員 (00598526)
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| Co-Investigator(Kenkyū-buntansha) |
NISHIDA Kotaro 神戸大学, 医学研究科, 講師 (00379372)
KAKUTANI Kenichiro 神戸大学, 医学部附属病院, 助教 (10533739)
MAENO Koichiro 神戸大学, 医学研究科, 助教 (70403269)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 椎間板変性 / 侵害受容性疼痛 / 神経障害性疼痛 / 変性 / 椎間板 / マクロファージ / なし |
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| Outline of Final Research Achievements |
We have previously shown that intervertebral disc and macrophages interaction induces pro-inflammatory reaction and pain related behavior. We clarified macrophages existence in degenerative disc not only in herniated disc disease but also lumbar canal stenosis. M1 macrophage, which plays inflammatory and tumoricidal activity, is exists in 95.5% of herniated disc disease and 95.6% of lumbar canal stenosis.
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