application of mechanoreceptors for the care of intervertebral disc degeneration
Project/Area Number |
24592197
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Orthopaedic surgery
|
Research Institution | Kobe University |
Principal Investigator |
DOITA Minoru 神戸大学, 医学(系)研究科(研究院), 医学研究員 (60237170)
|
Co-Investigator(Kenkyū-buntansha) |
NISHIDA Kotaro 神戸大学, 医学研究科, 講師 (00379372)
KAKUTANI Kenichiro 神戸大学, 医学部附属病院, 助教 (10533739)
MAENO Koichiro 神戸大学, 医学研究科, 助教 (70403269)
|
Project Period (FY) |
2012-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
Keywords | 椎間板 / 変性 / 抗老化 / メカノレセプター / integrinα5β1 / 椎間板組織 |
Outline of Final Research Achievements |
SIRT1 prevented the apoptosis of intervetebral disc cells induced by low nutrition condition. Mechanoreceptors, integrin, involoved in interbertebral disc degeneration.
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Report
(4 results)
Research Products
(6 results)
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[Journal Article] Functional Impact of Integrin alpha5beta1 on the Homeostasis of Intervertebral Discs: A Study of Mechanotransduction Pathways Using a Novel Dynamic Loading Organ Culture System2014
Author(s)
Kurakawa, T.Kakutani, K.Morita, Y. Kato, Y.Yurube, T.Hirata, H. Miyazaki, S. Terashima, Y.Maeno, K Takada, T. Doita, M. Kurosaka, M. Inoue, N. Masuda, K. Nishida, K. .
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Journal Title
Spine J
Volume: 15
Issue: 3
Pages: 417-26
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Presentation] Integrin alpha5/beta1 mechanotransduction is involved with notochordal-cell disappearance in early intervertebral disc degeneration.2014
Author(s)
"Takuto Kurakawa*, Kenichiro Kakutani*, Yusuke Morita, Yuki Kato, Yoshiki Terashima*, Shingo Miyazaki*, Hiroaki Hirata*, Takashi Yurube*, Toru Takada*, Koichiro Maeno*, Masahiro Kurosaka*, Koichi Masuda, Nozomu Inoue, Kotaro Nishida*
Organizer
41st Annual Meeting of the International Society for the Study of the Lumber Spine
Place of Presentation
韓国(ソウル)
Year and Date
2014-06-03 – 2014-06-07
Related Report
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