application of mechanoreceptors for the care of intervertebral disc degeneration

• Project/Area Number: 24592197
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Orthopaedic surgery
• Research Institution: Kobe University
• Principal Investigator: DOITA Minoru 神戸大学, 医学(系)研究科(研究院), 医学研究員 (60237170)
• Co-Investigator(Kenkyū-buntansha): NISHIDA Kotaro 神戸大学, 医学研究科, 講師 (00379372) ; KAKUTANI Kenichiro 神戸大学, 医学部附属病院, 助教 (10533739) ; MAENO Koichiro 神戸大学, 医学研究科, 助教 (70403269)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 椎間板 / 変性 / 抗老化 / メカノレセプター / integrinα５β１ / 椎間板組織

Outline of Final Research Achievements

SIRT1 prevented the apoptosis of intervetebral disc cells induced by low nutrition condition. Mechanoreceptors, integrin, involoved in interbertebral disc degeneration.

Research Products

• [Journal Article] Functional Impact of Integrin alpha5beta1 on the Homeostasis of Intervertebral Discs: A Study of Mechanotransduction Pathways Using a Novel Dynamic Loading Organ Culture System (2014)
  • Author(s): Kurakawa, T.Kakutani, K.Morita, Y. Kato, Y.Yurube, T.Ｈirata, H. Miyazaki, S. Terashima, Y.Maeno, K Takada, T. Doita, M. Kurosaka, M. Inoue, N. Masuda, K. Nishida, K. .
  • Journal Title: Spine J Volume: 15 Issue: 3 Pages: 417-26
  • DOI: 10.1016/j.spinee.2014.12.143
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] 動的圧迫負荷による脊索由来椎間板髄核細胞の変化 (2014)
  • Author(s): 蔵川 拓外*、角谷 賢一朗*、森田 有亮、加藤 優喜、寺嶋 良樹*、宮崎 真吾*、平田 裕亮*、由留部 崇*、前野 耕一郎*、髙田 徹*、舛田 浩一、井上 望、黒坂 昌弘*、西田 康太郎*
  • Organizer: 第29回日本整形外科学会基礎学術集会
  • Place of Presentation: 鹿児島
  • Year and Date: 2014-10-09 – 2014-10-10
• [Presentation] Integrin alpha5/beta1 mechanotransduction is involved with notochordal-cell disappearance in early intervertebral disc degeneration. (2014)
  • Author(s): "Takuto Kurakawa*, Kenichiro Kakutani*, Yusuke Morita, Yuki Kato, Yoshiki Terashima*, Shingo Miyazaki*, Hiroaki Hirata*, Takashi Yurube*, Toru Takada*, Koichiro Maeno*, Masahiro Kurosaka*, Koichi Masuda, Nozomu Inoue, Kotaro Nishida*
  • Organizer: 41st Annual Meeting of the International Society for the Study of the Lumber Spine
  • Place of Presentation: 韓国（ソウル）
  • Year and Date: 2014-06-03 – 2014-06-07
• [Presentation] 椎間板動的圧迫負荷による脊索由来髄核細胞の変化 (2014)
  • Author(s): 蔵川 拓外*、角谷 賢一朗*、森田 有亮、加藤 優喜、寺嶋 良樹*、宮崎 真吾*、平田 裕亮*、由留部 崇*、髙田 徹*、前野 耕一郎*、土井田 稔、舛田 浩一、井上 望、黒坂 昌弘*、西田 康太郎*
  • Organizer: 第43回日本脊椎脊髄病学会
  • Place of Presentation: 神戸
  • Year and Date: 2014-04-17 – 2014-04-19
• [Presentation] The role of α5β1 integrin in the mechanically initiated intervertebral disc degeneration. (2013)
  • Author(s): Kurakawa T. Kakutani K., Morita Y., Takada T. Maeno K. Yurube T. Zhang Z. Yamamoto J., Hirata H., Doita M., Kurosaka M., Nishida K.
  • Organizer: 米国整形外科学会
  • Place of Presentation: 米国
• [Presentation] Biologic Responses of Rat Intervertebral Discs to mechanical load using dynamic organ culture system (2012)
  • Author(s): Kurakawa T. Kakutani K., Morita Y., Takada T. Maeno K. Yurube T. Zhang Z. Yamamoto J., Hirata H., Doita M., Kurosaka M., Nishida K.
  • Organizer: 国際腰椎学会
  • Place of Presentation: オランダ