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The development of methods to evaluate a sensory or motor dysfunction objectively, using magnetoencephalography.

Research Project

Project/Area Number 24592198
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Orthopaedic surgery
Research InstitutionHiroshima University

Principal Investigator

NAKANISHI KAZUYOSHI  広島大学, 病院(医), 講師 (60403557)

Co-Investigator(Kenkyū-buntansha) OCHI MITSUO  広島大学, その他部局等, 学長 (70177244)
SUNAGAWA TORU  広島大学, 大学院医歯薬保健学研究院, 教授 (40335675)
TANAKA NOBUHIRO  広島大学, 病院, 講師 (20363062)
Project Period (FY) 2012-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Keywords体性感覚誘発磁界 / fMRI / 痛み / 感覚障害 / 運動障害 / 体性間隔誘発磁界
Outline of Final Research Achievements

The aim of this study was to develop methods which can evaluate a sensory or motor dysfunction objectively, using magnetoencephalography (MEG), functional magnetic resonance imaging (fMRI), and other electrophysiological techniques. A new sensor device to monitor the acceleration and angular degree of finger motion, a tactile and pressure stimulator, and a system which can evaluate the
subjective degree of pain following electrical pain stimulation to skin in real time during MEG or fMRI measurements were developed and/or improved through this study. With the help of these appliances, we studied the MEG, fMRI, and motor-evoked potentials in patients with cervical spinal cord or peripheral nerve disorder. The availability and efficacy of the treatment methods which accompany these devices is clarified, by demonstrating how they objectively and non-invasively detect the extent of sensory or motor dysfunction.

Report

(5 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (29 results)

All 2016 2015 2014 2013 2012 Other

All Journal Article (9 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 9 results,  Open Access: 1 results,  Acknowledgement Compliant: 4 results) Presentation (20 results) (of which Int'l Joint Research: 1 results,  Invited: 13 results)

  • [Journal Article] 糖尿病を合併した頸椎圧迫性脊髄症における運動路の電気生理学的評価2016

    • Author(s)
      中西一義, 田中信弘, 亀井直輔, 平松武, 宇治郷諭, 住吉範彦, 力田高徳, 高澤篤之, 越智光夫
    • Journal Title

      脊髄機能診断学

      Volume: 37巻1号 Pages: 54-58

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Electrophysiological assessments of the motor pathway in diabetic patients with compressive cervical myelopathy.2015

    • Author(s)
      Nakanishi K, Tanaka N, Kamei N, Hiramatsu T, Ujigo S, Sumiyoshi N, Rikita T, Takazawa A, Ochi M.
    • Journal Title

      J Neurosurg Spine.

      Volume: 23(6) Issue: 6 Pages: 707-714

    • DOI

      10.3171/2015.3.spine141060

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Electrophysiological assessments of the motor pathway in diabetic patients with compressive cervical myelopathy.2015

    • Author(s)
      Kazuyoshi Nakanishi, Nobuhiro Tanaka, Naosuke Kamei, Takeshi Hiramatsu, Satoshi Ujigo, Norihiko Sumiyoshi, Takanori Rikita, Atsushi Takazawa, Mitsuo Ochi.
    • Journal Title

      J Neurosurg Spine.

      Volume: in press.

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Dipole orientation of receptive fields in the somatosensory cortex after stimulation of the posterior tibial nerve in humans.2014

    • Author(s)
      Nakanishi K, Inoue K, Hadoush H, Sunagawa T, Ochi M.
    • Journal Title

      J Clin Neurophysiol.

      Volume: Jun;31(3) Issue: 3 Pages: 236-40

    • DOI

      10.1097/wnp.0000000000000044

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Electrophysiological evidence of functional improvement in the corticospinal tract after laminoplasty in patients with cervical compressive myelopathy: clinical article.2014

    • Author(s)
      Nakanishi K, Tanaka N, Kamei N, Ohta R, Fujioka Y, Hiramatsu T, Ujigo S, Ochi M.
    • Journal Title

      J Neurosurg Spine.

      Volume: Aug;21(2) Issue: 2 Pages: 210-6

    • DOI

      10.3171/2014.4.spine13545

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Electrophysiological evidence of functional improvement in the corticospinal tract after laminoplasty in the patients with cervical compressive myelopathy.2014

    • Author(s)
      Kazuyoshi Nakanishi, Nobuhiro Tanaka, Naosuke Kamei, Ryo Ohta, Yuki Fujioka, Takeshi Hiramatsu, Satoshi Ujigo, Mitsuo Ochi.
    • Journal Title

      Journal of Neurosurgery: Spine

      Volume: in press

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Dipole orientation of receptive fields in the somatosensory cortex following stimulation of the posterior tibial nerve in humans.2014

    • Author(s)
      Kazuyoshi Nakanishi, Ken Inoue, Hikmat Hadoush, Toru Sunagawa, Mitsuo Ochi.
    • Journal Title

      Journal of Clinical Neurophysiology

      Volume: in press

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Somatosensory mechanical response and digit somatotopy within cortical areas of the postcentral gyrus in humans: An MEG study.2012

    • Author(s)
      Inoue K, Nakanishi K, Hadoush H, Kurumadani H, Hashizume A, Sunagawa T, Ochi M.
    • Journal Title

      Hum Brain Mapp.

      Volume: e-publish Issue: 7 Pages: 1559-1567

    • DOI

      10.1002/hbm.22012

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Somatosensory cortical plasticity after toe-to-index transfer.2012

    • Author(s)
      Hadoush H, Sunagawa T, Nakanishi K, Ochi M.
    • Journal Title

      Neuroreport.

      Volume: 23 Issue: 17 Pages: 1000-1005

    • DOI

      10.1097/wnr.0b013e32835a649e

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] 脊髄・神経根機能診断の最近の進歩<MEPによる脊髄機能評価(胸髄)>2015

    • Author(s)
      中西一義, 田中信弘, 亀井直輔, 平松武, 宇治郷諭, 住吉範彦, 力田高徳, 越智光夫
    • Organizer
      第45回日本臨床神経生理学会学術大会
    • Place of Presentation
      大阪国際会議場(大阪市北区)
    • Year and Date
      2015-11-05
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 頸椎圧迫性脊髄症術後における皮質脊髄路機能の経時的変化2015

    • Author(s)
      中西 一義, 田中 信弘, 亀井 直輔, 住吉 範彦, 力田 高徳, 高澤 篤之, 越智 光夫
    • Organizer
      第30回日本整形外科学会基礎学術集会
    • Place of Presentation
      富山国際会議場(富山市大手町)
    • Year and Date
      2015-10-22
    • Related Report
      2015 Annual Research Report
  • [Presentation] Electrophysiological assessments of the motor passway in diabetic patients with compressive cervical myelopathy.2015

    • Author(s)
      Nakanishi K, Tanaka N, Kamei N, Hiramatsu T, Ujigo S, Sumiyoshi N, Rikita T, Takazawa A, Ochi M.
    • Organizer
      31st Annual Meeting Cervical Spine Research Society - European section
    • Place of Presentation
      The British Museum, London(United Kingdom of Great Britain and Northern Ireland)
    • Year and Date
      2015-05-26
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 糖尿病を合併した頸椎圧迫性脊髄症における運動路の電気生理学的評価2015

    • Author(s)
      中西一義, 田中信弘, 亀井直輔, 平松武, 宇治郷諭, 住吉範彦, 力田高徳, 高澤篤之, 越智光夫
    • Organizer
      第88回日本整形外科学会学術総会
    • Place of Presentation
      神戸ポートピアホテル他(神戸市中央区)
    • Year and Date
      2015-05-21
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Electrophysiological assessments of the motor passway in diabetic patients with compressive cervical myelopathy.2015

    • Author(s)
      Kazuyoshi Nakanishi, Nobuhiro Tanaka, Naosuke Kamei, Takeshi Hiramatsu, Satoshi Ujigo, Norihiko Sumiyoshi, Takanori Rikita, Atsushi Takazawa, Mitsuo Ochi
    • Organizer
      6th CSRS-AP
    • Place of Presentation
      Pacifico Yokohama, Yokohama, Japan
    • Year and Date
      2015-03-27 – 2015-03-28
    • Related Report
      2014 Research-status Report
  • [Presentation] 糖尿病を合併した頸椎圧迫性脊髄症における運動路の電気生理学的評価2015

    • Author(s)
      中西一義、田中信弘、亀井直輔、平松武、宇治郷諭、住吉範彦、力田高徳、高澤篤之、越智光夫
    • Organizer
      第36回脊髄機能診断研究会
    • Place of Presentation
      イイノホール&カンファレンスセンター(東京都千代田区)
    • Year and Date
      2015-02-07
    • Related Report
      2014 Research-status Report
  • [Presentation] 頸椎圧迫性脊髄症における糖尿病合併の運動路の電気生理学的評価に及ぼす影響2014

    • Author(s)
      中西一義、田中信弘、亀井直輔、平松武、宇治郷諭、住吉範彦、力田高徳、越智光夫
    • Organizer
      第44回日本臨床神経生理学会学術大会
    • Place of Presentation
      福岡国際会議場(福岡市博多区)
    • Year and Date
      2014-11-19 – 2014-11-21
    • Related Report
      2014 Research-status Report
  • [Presentation] 糖尿病を合併した頸椎圧迫性脊髄症術における運動路の電気生理学的評価2014

    • Author(s)
      中西一義、田中信弘、亀井直輔、平松武、宇治郷諭、住吉範彦、力田高徳、越智光夫
    • Organizer
      第29回日本整形外科学会基礎学術集会
    • Place of Presentation
      城山観光ホテル(鹿児島市新照院町)
    • Year and Date
      2014-10-09 – 2014-10-10
    • Related Report
      2014 Research-status Report
  • [Presentation] 頸椎圧迫性脊髄症術後の中枢運動伝導時間の変化2014

    • Author(s)
      中西一義、田中信弘、亀井直輔、平松武、宇治郷諭、住吉範彦、力田高徳、越智光夫
    • Organizer
      第87回日本整形外科学会学術総会
    • Place of Presentation
      神戸国際会議場(神戸市中央区)
    • Year and Date
      2014-05-22 – 2014-05-25
    • Related Report
      2014 Research-status Report
  • [Presentation] 頸椎圧迫性脊髄症術後の中枢運動伝導時間の変化2014

    • Author(s)
      中西一義、田中信弘、亀井直輔、平松武、宇治郷諭、住吉範彦、力田高徳、越智光夫
    • Organizer
      第43回日本脊椎脊髄病学会
    • Place of Presentation
      国立京都国際会館(京都市左京区)
    • Year and Date
      2014-04-17 – 2014-04-19
    • Related Report
      2014 Research-status Report
  • [Presentation] 頸椎圧迫性脊髄症術後の中枢運動伝導時間の変化2014

    • Author(s)
      中西一義,田中信弘,亀井直輔,平松武、宇治郷諭、住吉範彦、力田高徳、越智光夫
    • Organizer
      第43回日本脊椎脊髄病学会学術集会
    • Place of Presentation
      国立京都国際会館(京都市左京区)
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 頸椎圧迫性脊髄症術後の中枢運動伝導時間の変化2014

    • Author(s)
      中西一義,田中信弘,亀井直輔,平松武、宇治郷諭、住吉範彦、力田高徳、越智光夫
    • Organizer
      第87回日本整形外科学会学術総会
    • Place of Presentation
      神戸ポートピアホテル他(神戸市中央区)
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] Electrophysiological evidence of functional improvement in the corticospinal tract after laminoplasty in the patients with cervical compressive myelopathy.2014

    • Author(s)
      Nakanishi K, Tanaka N, Kamei N, Hiramatsu T, Ujigo S, Sumiyoshi N, Rikita T, Ochi M.
    • Organizer
      5th Annual Meeting of the Cervical Spine Research Society- Asia Pacific Section(5th CSRS-AP)
    • Place of Presentation
      Ho Chi Minh City, Viet Nam
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 頸椎圧迫性脊髄症術後の中枢運動伝導時間の変化2013

    • Author(s)
      中西一義、田中信弘、亀井直輔、平松武、宇治郷諭、越智光夫
    • Organizer
      第43回日本臨床神経生理学会学術大会
    • Place of Presentation
      高知県立県民文化ホール他(高知市本町)
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 頚椎部・胸椎部圧迫性脊髄症診断における中枢運動伝導時間計測の有用性2013

    • Author(s)
      中西一義、田中信弘、亀井直輔、宇治郷諭、平松 武、住吉範彦、力田高徳、越智光夫
    • Organizer
      第43回日本臨床神経生理学会学術大会
    • Place of Presentation
      高知県立県民文化ホール他(高知市本町)
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 頸椎圧迫性脊髄症術後の中枢運動伝導時間の変化2013

    • Author(s)
      中西一義,田中信弘,亀井直輔,大田亮、藤岡悠樹、平松武、宇治郷諭、越智光夫
    • Organizer
      第28回日本整形外科学会基礎学術集会
    • Place of Presentation
      幕張メッセ国際会議場(千葉市美浜区)
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 頸椎圧迫性脊髄症術後の中枢運動伝導時間の変化

    • Author(s)
      中西一義,田中信弘,亀井直輔,平松武、宇治郷諭、住吉範彦、力田高徳、越智光夫
    • Organizer
      第35回脊髄機能診断研究会
    • Place of Presentation
      東京商工会議所ビルディング/国際会議場(東京都千代田区)
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 高次脳機能解析技術を用いた運動・感覚障害の客観的評価法の開発

    • Author(s)
      中西一義、越智光夫
    • Organizer
      広島大学新技術説明会2012 in 広島
    • Place of Presentation
      広島市
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] 中枢運動伝導時間計測による頚椎部・胸椎部脊髄症の機能評価

    • Author(s)
      中西一義、田中信弘、亀井直輔、大田亮、藤岡悠樹、平松武、宇治郷諭、越智光夫
    • Organizer
      第1回Japan Association of Spine surgeons with Ambition
    • Place of Presentation
      東京都
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] 整形外科領域における脊髄機能の電気生理学的評価

    • Author(s)
      中西一義
    • Organizer
      広島赤十字・原爆病院整形外科病診連携の会
    • Place of Presentation
      広島市
    • Related Report
      2012 Research-status Report
    • Invited

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Published: 2013-05-31   Modified: 2019-07-29  

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