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Establishment of a rodent model of functional neuromuscular stimulation for motor therapy after spinal cord injury

Research Project

Project/Area Number 24592199
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Orthopaedic surgery
Research InstitutionYamaguchi University

Principal Investigator

KANCHIKU Tsukasa  山口大学, 医学部附属病院, 講師 (30464324)

Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords脊髄損傷 / リハビリテーション / 機能的電気刺激
Outline of Final Research Achievements

We examined the effectiveness of functional electrical stimulation with kHz in gait rhythm stimulation therapy. Tests were performed using 20 mature female Fischer rats.FNS was administered for three days from seventh day post-injury. Rats were divided into four groups (5 rats/group), including the FNS treatment 75 Hz group (iSCI FNS 75Hz), 8 kHz group (iSCI FNS 8 kHz), injury control group (iSCI-NT), and normal group (Normal-CT), and compared. There was no significant difference in BBB scores at any point between the four groups. In 3D gait analysis, compared with the injury control group, the 8 kHz group showed a significant improvement in synergistic movement of both hindlimb. We suggest that kHz stimulation is effective in gait rhythm stimulation using NMES.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (11 results)

All 2015 2014 2013 2012

All Journal Article (2 results) (of which Peer Reviewed: 1 results) Presentation (9 results)

  • [Journal Article] 急性期ニューロリハビリテーションの確立を目指したラット脊髄損傷後の機能的神経筋刺激治療モデルの開発2015

    • Author(s)
      寒竹 司、鈴木秀典、今城靖明、吉田佑一郎、守屋淳詞、末富 裕、西田周泰、高橋洋平、田口敏彦
    • Journal Title

      関節外科

      Volume: 34 Pages: 178-186

    • Related Report
      2014 Annual Research Report
  • [Journal Article] Development of less invasive neuromuscular electrical stimulation model for motor therapy in rodents2012

    • Author(s)
      Kanchiku T, Kato Y, Suzuki H, Imajo Y, Yoshida Y, Moriya A, Taguchi T, Jung R.
    • Journal Title

      Journal of Spinal Cord Medicine

      Volume: 35 Issue: 3 Pages: 162-169

    • DOI

      10.1179/2045772312y.0000000009

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] ラット脊髄損傷後の機能的神経筋電気刺激治療モデルの確立―急性期ニューロリハビリテーションの確立に向けて2014

    • Author(s)
      寒竹 司 鈴木秀典 今城靖明 吉田佑一郎 守屋淳詞 末富 裕 西田周泰 高橋洋平 田口敏彦
    • Organizer
      第29回日本整形外科学会基礎学術集会
    • Place of Presentation
      城山観光ホテル(鹿児島県鹿児島市)
    • Year and Date
      2014-10-09 – 2014-10-10
    • Related Report
      2014 Annual Research Report
  • [Presentation] ラット脊髄損傷後の機能的電気刺激治療モデルの確立―再生治療後の急性期ニューロリハビリテーションの確立に向けて2014

    • Author(s)
      寒竹 司 鈴木秀典 今城靖明 吉田佑一郎 守屋淳詞 末富 裕 西田周泰 高橋洋平 田口敏彦
    • Organizer
      第41回生体電気物理刺激研究会
    • Place of Presentation
      横浜シンポジア(神奈川県横浜市)
    • Year and Date
      2014-04-05
    • Related Report
      2014 Annual Research Report
  • [Presentation] ラット脊髄損傷後の機能的電気刺激治療モデルの確立:再生治療後の急性期リハビリテーションの確立に向けて2014

    • Author(s)
      寒竹司、鈴木秀典、今城靖明、吉田佑一郎、守屋淳詞、末富裕、西田周泰、高橋洋平、田口敏彦
    • Organizer
      第41回日本生体電気・物理刺激研究会
    • Place of Presentation
      横浜市(横浜シンポジア)
    • Related Report
      2013 Research-status Report
  • [Presentation] ラット脊髄不全損傷後の機能的神経筋電気刺激治療による短期治療効果2013

    • Author(s)
      末冨裕、寒竹司、鈴木秀典、今城靖明、吉田佑一郎、守屋淳詞、田口敏彦
    • Organizer
      第28回日本整形外科学会基礎学術集会
    • Place of Presentation
      千葉市(幕張メッセ)
    • Related Report
      2013 Research-status Report
  • [Presentation] Short-term recovery of interlimb coordination during locomotion in incomplete spinal cord injury rats after less invasive neuromuscular electrical stimulation therapy2013

    • Author(s)
      Tsukasa Kanchiku, Yasuaki Imajo, Yuichiro Yoshida, Atsushi Moriya, Yu Suetomi, Norihiro Nishida, Youhei Takahashi, Toshihiko Taguchi
    • Organizer
      52nd Annual Meeting of International Spinal Cord Society
    • Place of Presentation
      イスタンブール(トルコ)
    • Related Report
      2013 Research-status Report
  • [Presentation] ラット脊髄不全損傷後の機能的神経筋電気刺激治療の短期効果2012

    • Author(s)
      守屋淳司、寒竹 司、田口俊彦
    • Organizer
      第49回日本リハビリテーション学会
    • Place of Presentation
      福岡国際会議場(福岡市)
    • Related Report
      2012 Research-status Report
  • [Presentation] ラット脊髄半切モデルにおける三次元歩行解析2012

    • Author(s)
      末富祐、寒竹 司、守屋淳司、田口敏彦
    • Organizer
      第27回日本整形外科学会基礎学術集会
    • Place of Presentation
      名古屋国際会議場(名古屋市)
    • Related Report
      2012 Research-status Report
  • [Presentation] ラット脊髄不全損傷後の機能的神経筋電気刺激治療の短期効果:三次元動作解析による検討2012

    • Author(s)
      守屋淳司、寒竹 司、田口敏彦
    • Organizer
      第27回日本整形外科学会基礎学術集会
    • Place of Presentation
      名古屋国際会議場(名古屋市)
    • Related Report
      2012 Research-status Report
  • [Presentation] Short-term recovery of interlimb coordination during locomotion in a rodent model with incomplete spinal cord injury after less invasive neuromuscular electrical stimulation therapy2012

    • Author(s)
      Kanchiku T, Suzuki H, Imajo Y, Yoshida Y, Taguchi T
    • Organizer
      Neuroscience 2012
    • Place of Presentation
      ニューオリンズ(USA)
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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