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Regenerative therapy for

Research Project

Project/Area Number 24592203
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Orthopaedic surgery
Research InstitutionKagoshima University

Principal Investigator

MASAHIKO Abematsu  鹿児島大学, 医学部・歯学部附属病院, 助教 (70448190)

Co-Investigator(Kenkyū-buntansha) KOMIYA Setsuro  鹿児島大学, 大学院医歯学総合研究科, 教授 (30178371)
SETOGUCHI Takao  鹿児島大学, 大学院医歯学総合研究科, 特任准教授 (40423727)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords脊髄損傷 / 霊長類 / 再生治療 / 幹細胞移植 / 再生 / iPS細胞
Outline of Final Research Achievements

Because we developed the study using the rabbit rat mouse spinal cord injury model so far, we applied the technique and developed a spinal injury model manufacture device for exclusive use of the crab-eating monkey.
After crush injury assuming spinal cord it, and evaluating a hindlimb function, graded dysfunction was found in three different injury energy of the mild medium degree, severeness according to size of the injury energy subsequently.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (17 results)

All 2014 2013 2012 Other

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Open Access: 1 results) Presentation (11 results) (of which Invited: 8 results) Book (1 results) Remarks (2 results)

  • [Journal Article] Metastatic bone tumors: Analysis of factors affecting prognosis and efficacy of CT and 18F-FDG PET-CT in identifying primary lesions.2014

    • Author(s)
      Shimada H, Setoguchi T, Yokouchi M, Sasaki H, Ishidou Y, Kawamura I, Abematsu M, Nagano S, Komiya S.
    • Journal Title

      Mol Clin Oncol.

      Volume: 2(5) Issue: 5 Pages: 875-881

    • DOI

      10.3892/mco.2014.326

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Treatment of a mouse model of spinal cord injury by transplantation of human iPS cell-derived long-term self-renewing neuroepithelial-like stem cells2012

    • Author(s)
      Fujimoto Y., Abematsu M., FalkA., Tsujimura K., Sanosaka T., Juliandi B.. Semi K., Namihira M., Komiya S., SmithA., Nakashima K,
    • Journal Title

      Stem Cells

      Volume: 30 Issue: 6 Pages: 1163-1173

    • DOI

      10.1002/stem.1083

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Induction of superficial cortical layer neurons from mouse embryonic stem cells by valproic acid2012

    • Author(s)
      Juliandi B, Abematsu M, Sanosaka T, Tsujimura K, Smith A, Nakashima K
    • Journal Title

      Neuroscience Research

      Volume: 72 Issue: 1 Pages: 23-31

    • DOI

      10.1016/j.neures.2011.09.012

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] Examination of a New MRI Severity Scoring System and Postoperative Results in Patients with Cervical Spinal Tumors2014

    • Author(s)
      Masahiko Abematsu, Hiroyuki Tominaga, Fumito Tanabe, Hiroki Tawaratsumida, Takuya Yamamoto, Kazunori Yone、Setsuro Komiya
    • Organizer
      CSRS AP 5 Viet Nam 2014
    • Place of Presentation
      Viet Nam
    • Year and Date
      2014-04-03 – 2014-04-08
    • Related Report
      2014 Annual Research Report
  • [Presentation] 脊髄髄膜腫におけるMRI画像所見による新規脊髄評価法と術後臨床成績の検討2013

    • Author(s)
      棈松昌彦、井尻幸成、川内義久、富村奈津子、米和徳、小宮節郎
    • Organizer
      第42回日本脊椎脊髄病学会
    • Place of Presentation
      沖縄
    • Related Report
      2013 Research-status Report
  • [Presentation] 脊髄損傷における神経ネットワークの再構築2013

    • Author(s)
      棈松昌彦、藤元祐介、井尻幸成、山元拓哉、米和徳、小宮節郎
    • Organizer
      第42回日本脊椎脊髄病学会
    • Place of Presentation
      沖縄
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 脊髄損傷に対する幹細胞移植と神経ネットワークの再構築2013

    • Author(s)
      棈松昌彦
    • Organizer
      第10回 名古屋脊椎脊髄セミナー2013
    • Place of Presentation
      名古屋
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] iPS由来神経幹細胞を用いた脊髄損傷再生治療2013

    • Author(s)
      棈松昌彦、藤元祐介、井尻幸成、山元拓哉、米和徳、小宮節郎
    • Organizer
      第28回 日本整形外科学会基礎学術集会
    • Place of Presentation
      千葉
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 脊髄損傷に対する神経幹細胞補充とエピジェネティックな分化制御による再生治療2012

    • Author(s)
      棈松 昌彦、他7名
    • Organizer
      第124回 西日本整形・災害外科学会学術集会
    • Place of Presentation
      大分
    • Related Report
      2012 Research-status Report
  • [Presentation] 脊髄損傷マウスに対するエピジェネティック治療と運動器回復能2012

    • Author(s)
      棈松 昌彦
    • Organizer
      第85回日本整形外科学会学術総会
    • Place of Presentation
      京都
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] Tracing transplanted neural stem cells by using IVIS system and specific cell ablation2012

    • Author(s)
      Masahiko Abematsu
    • Organizer
      International Society for Stem Cell Research 9th Annual Meeting
    • Place of Presentation
      Tokyo
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] クロマチンリモデリングによる脊髄損傷再生治療2012

    • Author(s)
      棈松 昌彦
    • Organizer
      第49回中部脊髄外科ワークショップ
    • Place of Presentation
      名古屋
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] 脊髄損傷マウスに対するエピジェネティック治療とそのメカニズム2012

    • Author(s)
      棈松 昌彦
    • Organizer
      第27回 日本整形外科学会基礎学術集会
    • Place of Presentation
      京都
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] 脊髄損傷に対する再生治療~エピジェネティックな制御を介して~2012

    • Author(s)
      棈松 昌彦
    • Organizer
      第40回日本関節病学会
    • Place of Presentation
      鹿児島
    • Related Report
      2012 Research-status Report
    • Invited
  • [Book] Neuroprotection and Regeneration of the Spinal Cord2014

    • Author(s)
      Masahiko Abematsu
    • Total Pages
      418
    • Publisher
      Springer
    • Related Report
      2013 Research-status Report
  • [Remarks] 寄附講座「近未来運動器医療創生学講座〔(医)くすのき会〕

    • URL

      http://www2.kufm.kagoshima-u.ac.jp/~mdio/list/o/o5/index.html

    • Related Report
      2013 Research-status Report
  • [Remarks] 寄附講座「近未来運動器医療創生学講座〔(医)くすのき会〕」

    • URL

      http://www2.kufm.kagoshima-u.ac.jp/~mdio/list/o/o5/index.html

    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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