| Project/Area Number |
24592207
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
IKEDA takumi 京都府立医科大学, 医学(系)研究科(研究院), 講師 (40453120)
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| Co-Investigator(Kenkyū-buntansha) |
MIKAMI Yasuo 京都府立医科大学, 医学研究科, 講師 (80360030)
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| Co-Investigator(Renkei-kenkyūsha) |
TABATA Yasuhiko 京都大学, 再生医科学研究所, 教授 (50211371)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 多血小板血漿 / ゼラチンβTCPスポンジ / 骨癒合 / 脊椎固定術 / 椎体形成術 / ゼラチンハイドロゲル / β-TCPスポンジ |
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| Outline of Final Research Achievements |
The positive effect on bone fusion using the combination of PRP and the gelatin β-TCP sponge is equivalent to that of autogenous bone grafting.
We also study the process of bone repair in a vertebral body defect model in order to use this biomaterial in vertebroplasty.
This method might be less invasive than autogenous bone grafting in terms of being able to induce bone fusion by autologous blood without impairing of healthy donor site. This method also has the advantage of being very safe to perform, because all these materials have already been extensively used clinically. The current study demonstrates that the bone fusion method using the combination of PRP and the gelatin β-TCP sponge could be an alternative to autogenous bone grafting in terms of its effectiveness, lower invasiveness, and safety.
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