Elucidation of the mechanism of myelination by glucocorticoids.
| Project/Area Number |
24592208
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
FUJIWARA HIROYOSHI 京都府立医科大学, 医学(系)研究科(研究院), 准教授 (90381962)
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| Co-Investigator(Kenkyū-buntansha) |
ODA RYO 京都府立医科大学, 医学研究科, 講師 (80516469)
TOKUNAGA DAISAKU 京都府立医科大学, 医学研究科, 准教授 (90343409)
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 末梢神経 / グルココルチコイド / 神経再生 |
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| Outline of Final Research Achievements |
Glucocorticoids improve the symptoms of peripheral nerve disorders, such as carpal tunnel syndrome and peripheral neuropathy.Schwann cells of the peripheral nerves express glucocorticoid receptors (GR), and glucocorticoids enhance the rate of myelin formation in vitro. Moreover, label-free biochemical imaging with Raman spectroscopy can be used to detect turnover of axon and myelin in peripheral nerve regeneration.
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Report
(5 results)
Research Products
(1 results)
