Elucidation of the mechanism of myelination by glucocorticoids.

Research Project

Project/Area Number	24592208
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Orthopaedic surgery
Research Institution	Kyoto Prefectural University of Medicine
Principal Investigator	FUJIWARA HIROYOSHI 京都府立医科大学, 医学(系)研究科(研究院), 准教授 (90381962)
Co-Investigator(Kenkyū-buntansha)	ODA RYO 京都府立医科大学, 医学研究科, 講師 (80516469) TOKUNAGA DAISAKU 京都府立医科大学, 医学研究科, 准教授 (90343409)
Project Period (FY)	2012-04-01 – 2016-03-31
Project Status	Completed (Fiscal Year 2015)
Budget Amount *help	¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000) Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000) Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000) Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords	末梢神経 / グルココルチコイド / 神経再生
Outline of Final Research Achievements	Glucocorticoids improve the symptoms of peripheral nerve disorders, such as carpal tunnel syndrome and peripheral neuropathy.Schwann cells of the　peripheral nerves express glucocorticoid receptors (GR), and glucocorticoids enhance the rate of myelin formation in vitro. Moreover, label-free biochemical imaging with Raman spectroscopy can be used to detect turnover of axon and myelin in peripheral nerve regeneration.

Report

(5 results)