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OPLL model mouse and mechanisms-de-ubiquitination leads to a posterior longitudinal ligament ossification breakthrough in proteomics

Research Project

Project/Area Number 24592215
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Orthopaedic surgery
Research InstitutionKurume University

Principal Investigator

Tsuru Michiyo  久留米大学, 疾患プロテオミクス遺伝子治療, 講師 (90368887)

Project Period (FY) 2012-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Keywords難病克服研究 / 後縦靭帯骨化症 / モデルマウス / プロテオミクス / 医薬品開発 / 難病 / 原因タンパク質 / 後縦靭帯骨化症モデルマウス / 治療製剤 / 創薬 / 治験 / プロテオーム / ノックアウトマウス / micro RNA / 脊柱靭帯骨化 / 糖尿病 / 再生医療 / 幹細胞 / POC / GCP / 有害事象 / 安全 / 臨床試験
Outline of Final Research Achievements

In our nation, there are roughly 300 intractable diseases identified by the Ministry of Health, Labour and Welfare. Our study focuses on just one of these diseases; however, I am confident that it represents a breakthrough in our understanding of diseases whose causes were previously unknown. I strongly believe that our research method, proteomics, has much to offer in the fight against intractable diseases. I have devoted 15 years to demonstrating my theory through the identification and purification of disease-specific proteins, and the establishment of mouse models for such. This study has the potential to stamp out intractable diseases around the world; it is what researchers and patients alike have been hoping for.

Report

(6 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (15 results)

All 2016 2015 2014 2013 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (5 results) (of which Invited: 3 results) Book (1 results) Remarks (5 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] Phenotypic analysis of conventional knockout mice lacking a protein responsible for ossification of the posterior longitudinal ligament2014

    • Author(s)
      M Tsuru, A Ono, K Uchida, Y Toyama, and K Nagata
    • Journal Title

      Nature Medicine

      Volume: in press

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Proline/Arginine-Rich End Leucine-Rich Repeat Protein Converts Stem Cells to Ligament Tissue and Zn(II) Influences Its Nuclear Expression.2013

    • Author(s)
      Michiyo Tsuru
    • Journal Title

      Stem Cells and Development

      Volume: 22(14) Issue: 14 Pages: 2057-2070

    • DOI

      10.1089/scd.2012.0695

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] 後縦靭帯骨化症原因タンパク質の発見と創薬研究2016

    • Author(s)
      津留美智代
    • Organizer
      第31回日本整形外科学会基礎学術集会
    • Place of Presentation
      福岡国際センター (福岡県・福岡市)
    • Year and Date
      2016-10-13
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 後縦靭帯骨化症原因タンパク質の発見と創薬研究2016

    • Author(s)
      津留美智代、梅山秀明、竹内正弘、永田見生
    • Organizer
      第31回日本整形外科学会基礎学術集会
    • Place of Presentation
      福岡国際会議場
    • Year and Date
      2016-10-13
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 疾患特異的タンパク質の統計学的探索方法2016

    • Author(s)
      津留美智代
    • Organizer
      国立研究開発法人 科学技術振興機構 バイオサイエンスデータベースセンター 文部科学省 厚生労働省
    • Place of Presentation
      東京大学 (東京都・文京区本郷)
    • Year and Date
      2016-10-05
    • Related Report
      2016 Annual Research Report
  • [Presentation] 後縦靭帯骨化症のプロテオーム解析2015

    • Author(s)
      津留美智代、小野睦、内田研造、戸山芳昭、永田見生
    • Organizer
      第30回日本整形外科学会基礎学術集会
    • Place of Presentation
      富山国際会議場
    • Year and Date
      2015-10-22 – 2015-10-23
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] 幹細胞由来靭帯組織作成による 整形外科、歯科分野における靭帯移植2013

    • Author(s)
      津留 美智代
    • Organizer
      Bio tech 2013
    • Place of Presentation
      東京ビッグサイト
    • Related Report
      2012 Research-status Report
  • [Book] AGEsと老化2013

    • Author(s)
      津留 美智代
    • Total Pages
      3
    • Publisher
      メディカルレビュー社
    • Related Report
      2012 Research-status Report
  • [Remarks] 西日本新聞一面 2013年3月13日

    • URL

      http://qnet.nishinippon.co.jp/medical/news/kyushu/post_1032.shtml

    • Related Report
      2012 Research-status Report
  • [Remarks] 毎日新聞社会面 2013年3月15日

    • URL

      http://mainichi.jp/area/news/20130315ddp012040012000c.html

    • Related Report
      2012 Research-status Report
  • [Remarks] 毎日新聞コラム 2013年4月6日

    • URL

      http://mainichi.jp/area/fukuoka/news/20130406ddlk40070338000c.html

    • Related Report
      2012 Research-status Report
  • [Remarks] 朝日新聞全国社会面 2013年4月23日

    • URL

      http://www.asahi.com/tech_science/update/0422/SEB201304220003.html

    • Related Report
      2012 Research-status Report
  • [Remarks] テレビ西日本 スーパーニュース 2013年3月29日

    • URL

      http://www.tnc.co.jp/home/program/timetable/?seldate=20130329

    • Related Report
      2012 Research-status Report
  • [Patent(Industrial Property Rights)] 脊柱靱帯骨化症モデル非ヒト動物、糖尿病モデル非ヒト動物、脊柱靱帯骨化症モデル細胞、スクリーニング方法、脊柱靱帯骨化症病変細胞の検出方法、脊柱靱帯骨化症診断用キット、及び脊柱靱帯骨化症治療剤2014

    • Inventor(s)
      津留美智代
    • Industrial Property Rights Holder
      津留美智代
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2014-129306
    • Filing Date
      2014-08-14
    • Related Report
      2014 Research-status Report
  • [Patent(Industrial Property Rights)] 脊柱靭帯骨化症バイオマーカー2014

    • Inventor(s)
      津留美智代
    • Industrial Property Rights Holder
      津留美智代
    • Industrial Property Rights Type
      特許
    • Filing Date
      2014-05-19
    • Related Report
      2013 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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