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Effects of Remnant Preservation on Properties of Hamstring Tendon Autograft after ACL Reconstruction in Sheep

Research Project

Project/Area Number 24592218
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Orthopaedic surgery
Research InstitutionHokkaido University

Principal Investigator

KONDO Eiji  北海道大学, 医学(系)研究科(研究院), 特任教授 (60374724)

Co-Investigator(Kenkyū-buntansha) YASUDA Kazunori  北海道大学, 大学院医学研究科, 教授 (20166507)
OUMIYA Katsuhiro  独立行政法人産業技術総合研究所, バイオメディカル研究部門, 研究部門長 (20223951)
KITAMURA Nobuto  北海道大学, 大学院医学研究科, 准教授 (80447044)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords四肢機能再建学
Outline of Final Research Achievements

The purpose of this study was to clarify the effects of the remnant tissue preservation in ACL reconstruction. Forty mature sheep were randomly divided into 2 groups of 10 animals each. In each animal, the right knee underwent ACL reconstruction using semitendinosus tendon autograft. In Group I, the remnant tissue was completely resected before reconstruction. In Group II, the graft was covered with the remnant tissue. In each group, 10 sheep were used for biomechanical and histological evaluations, at 4 and 12 weeks after surgery. The cross-sectional area of the graft was significantly thicker in Group II than in Group I. The anterior laxity was significantly lower in Group II than in Group I. Mechanoreceptors and proprioceptive fibres were found in all graft of Group II. The present study demonstrated that preservation of the remnant tissues may accelerate the remodeling process of the collagen matrix.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (36 results)

All 2015 2014 2013 2012 Other

All Journal Article (16 results) (of which Peer Reviewed: 15 results) Presentation (17 results) (of which Invited: 6 results) Book (3 results)

  • [Journal Article] The role of fibers in the femoral attachment of the ACL in resisting tibial displacements.2015

    • Author(s)
      Kawaguchi Y, Kondo E, Takeda R, Akita K, Yasuda K, Amis AA.
    • Journal Title

      Arthroscopy

      Volume: 31 Issue: 3 Pages: 435-44

    • DOI

      10.1016/j.arthro.2014.08.033

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Biomechanical analysis of knee laxity with isolated anteromedial or posterolateral bundle-deficient anterior cruciate ligament2014

    • Author(s)
      Kondo E, Merican AM, Yasuda K, Amis AA
    • Journal Title

      Arthroscopy

      Volume: 30(3) Issue: 3 Pages: 335-343

    • DOI

      10.1016/j.arthro.2013.12.003

    • Related Report
      2014 Annual Research Report 2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Intra-articular administration of hyaluronic acid increases the volume of the hyaline cartilage regenerated in a large osteochondral defect by implantation of a double-network gel2014

    • Author(s)
      Fukui T, Kitamura N, Kurokawa T, Yokota M, Kondo E, Gong JP, Yasuda K
    • Journal Title

      Journal of Materials Science-Materials in Medicine

      Volume: 25 Issue: 4 Pages: 1173-82

    • DOI

      10.1007/s10856-013-5139-3

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The morphology and functions of articular chondrocytes on a honeycomb-patterned surface.2014

    • Author(s)
      Eniwumide JO, Tanaka M, Nagai N, Morita Y, de Bruijn J, Yamamoto S, Onodera S, Kondo E, Yasuda K, Shimomura M
    • Journal Title

      Biomed Res Int

      Volume: 2014 Pages: 710354-710354

    • DOI

      10.1155/2014/710354

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Beta-tricalcium phosphate shows superior absorption rate and osteoconductivity compared to hydroxyapatite in open-wedge high tibial osteotomy2013

    • Author(s)
      Onodera J, Kondo E, Omizu N, Ueda D, Yagi T, Yasuda K
    • Journal Title

      Knee Surgery, Sports Traumatology, Arthroscopy

      Volume: - Issue: 11 Pages: 2763-2770

    • DOI

      10.1007/s00167-013-2681-y

    • NAID

      120005672363

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Biomechanical characteristics of three pivot shift maneuvers for the anterior cruciate ligament-deficient knee: In vivo evaluations using an electromagnetic sensor system2013

    • Author(s)
      Kitamura N, Yokota M, Kondo E, Miyatake S, Nagamune S, Yasuda K
    • Journal Title

      Am J Sports Med

      Volume: 41 Issue: 11 Pages: 2500-2506

    • DOI

      10.1177/0363546513499529

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] A quantitative technique to create a femoral tunnel at the averaged center of the anteromedial bundle attachment in anatomic double-bundle anterior cruciate ligament reconstruction2013

    • Author(s)
      Kai S, Kondo E, Kitamura N, Kawaguchi Y, Inoue M, Amis AA, Yasuda K
    • Journal Title

      BMC Musculoskelet Disord

      Volume: 14 Issue: 1 Pages: 189-189

    • DOI

      10.1186/1471-2474-14-189

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Prospective Clinical Comparisons of Semitendinosus Versus Semitendinosus and Gracilis Tendon Autografts for Anatomic Double-bundle Anterior Cruciate Ligament Reconstruction2013

    • Author(s)
      Inagaki Y, Kondo E, Kitamura N, Onodera J, Yagi T , Tanaka Y, Yasuda K
    • Journal Title

      J Orthop Sci

      Volume: 18(5) Issue: 5 Pages: 754-761

    • DOI

      10.1007/s00776-013-0427-9

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Tunnel enlargement and coalition after anatomic double-bundle anterior cruciate ligament reconstruction with hamstring tendon autografts: a computed tomography study2013

    • Author(s)
      Kawaguchi Y, Kondo E, Onodera J, Kitamura N, Sasaki T, Yagi T, Yasuda K
    • Journal Title

      Orthop J Sports Med

      Volume: 1 Issue: 1 Pages: 1-9

    • DOI

      10.1177/2325967113486441

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] A Novel Medial Collateral Ligament Reconstruction Procedure Using Semitendinosus Tendon Autograft in Patients With Multiligamentous Knee Injuries: Clinical Outcomes2013

    • Author(s)
      Kitamura N, Ogawa M, Kondo E, Kitayama S, Tohyama H, Yasuda K
    • Journal Title

      Am J Sports Med

      Volume: 41(6) Issue: 6 Pages: 1274-1281

    • DOI

      10.1177/0363546513485716

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] 膝前十字靱帯再腱術―最新の治療戦略― 遺残組織を温存させた解剖学的2重束前十字靱帯再腱術―断裂遺残組織を温存したdouble-bundle reconstruction2013

    • Author(s)
      近藤英司、安田和則
    • Journal Title

      整形外科最小侵襲手術ジャーナル

      Volume: 66 Pages: 73-78

    • Related Report
      2013 Research-status Report
  • [Journal Article] 遺残組織を温存した解剖学的2束前十字靱帯再建術の関節鏡学的評価(第一報)2013

    • Author(s)
      2. 小野寺純、近藤英司、北村信人、河口泰之、甲斐秀顯、横田正司、八木知徳、安田和則
    • Journal Title

      日本関節鏡・膝・スポーツ整形外科学会雑誌

      Volume: 38(1) Pages: 76-77

    • Related Report
      2013 Research-status Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] 膝屈筋腱―ハイブリッド代用材料を用いた前十字靭帯再建後の骨孔径変化:1束再建と解剖学的2重束再建の比較2013

    • Author(s)
      3. 河口泰之、近藤英司、北村信人、甲斐秀顯、井上雅之、安田和則
    • Journal Title

      北海道整形災害外科学会雑誌

      Volume: 52(1) Pages: 16-22

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Flurbiprofen Concentration in the Soft Tissues Is Higher after Topical Application Than after Oral Administration.2013

    • Author(s)
      Kai S, Kondo E, Kawaguchi Y, Kitamura N, Yasuda K.
    • Journal Title

      Br J Clin Pharmacol

      Volume: 75(3) Issue: 3 Pages: 799-804

    • DOI

      10.1111/j.1365-2125.2012.04394.x

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] 変形性膝関節症における膝後十字靱帯前外側および後内側線維束の力学的特性2012

    • Author(s)
      小野寺純、近藤英司、安田和則、大水信幸、上田大輔、八木知徳
    • Journal Title

      日本関節鏡・膝・スポーツ整形外科学会雑誌

      Volume: 37(2) Pages: 276-277

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Clinical comparison of two suspensory fixation devices for anatomic double-bundle anterior cruciate ligament reconstruction2012

    • Author(s)
      Kondo E, Yasuda K, Miyatake S, KitamuraN, Tohyama H, Yagi T
    • Journal Title

      Knee Surg Sports Traumatol Arthrosc

      Volume: 20(7) Issue: 7 Pages: 1261-1267

    • DOI

      10.1007/s00167-011-1687-6

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] 遺残靭帯組織温存ACL再建ヒツジモデルにおける自家移植腱の機能再建構築および機械受容器再生に関する生体力学的・免疫組織学的評価2014

    • Author(s)
      高橋恒存、近藤英司、小野寺純、河口泰之、宮武 慎、北村信人、岩崎倫政、安田和則
    • Organizer
      第29回日本整形外科学会基礎学術集会
    • Place of Presentation
      城山観光ホテル〈鹿児島市)
    • Year and Date
      2014-10-09 – 2014-10-10
    • Related Report
      2014 Annual Research Report
  • [Presentation] 遺残組織を温存させた解剖学的2束前十字靱帯再建術2014

    • Author(s)
      近藤英司、北村信人、安田和則、岩崎倫政
    • Organizer
      第6回日本関節鏡・膝・スポーツ整形外科学会
    • Place of Presentation
      広島国際会議場(広島市)
    • Year and Date
      2014-07-24 – 2014-07-26
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Effects of Remnant Ligament Tissue Preservation on the Clinical Outcome after Anatomic Double-bundle Anterior Cruciate Ligament Reconstruction.2014

    • Author(s)
      Kondo E.
    • Organizer
      Asia-Pacific Knee, Arthroscopy and Sports Medicine Society
    • Place of Presentation
      奈良公会堂(奈良)
    • Year and Date
      2014-04-14 – 2014-04-15
    • Related Report
      2014 Annual Research Report
  • [Presentation] 遺残組織を温存させた解剖学的2束前十字靱帯再建術2013

    • Author(s)
      近藤英司、北村信人、安田和則
    • Organizer
      第39回日本整形外科スポーツ医学会
    • Place of Presentation
      ウインク愛知、名古屋市
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 経脛骨骨孔手技を用いた解剖学的2束前十字靭帯再建術における骨孔癒合と拡大の実態:MPR-CTを用いた前向き予後研究2013

    • Author(s)
      小野寺純、近藤英司、河口泰之、北村信人、八木知徳、安田和則
    • Organizer
      第5回日本関節鏡・膝・スポーツ整形外科学会
    • Place of Presentation
      札幌コンベンションセンター、札幌市
    • Related Report
      2013 Research-status Report
  • [Presentation] 遺残靭帯組織の温存が解剖学的2束前十字靭帯再建術の臨床成績に与える効果2013

    • Author(s)
      近藤英司、安田和則、北村信人、小野寺純、河口泰之、横田正司、福井孝明、後藤佳子
    • Organizer
      第5回日本関節鏡・膝・スポーツ整形外科学会
    • Place of Presentation
      札幌コンベンションセンター、札幌市
    • Related Report
      2013 Research-status Report
  • [Presentation] 膝屈筋腱を用いた解剖学的2束前十字靭帯再建術後の骨孔融合と骨孔径変化:CTを用いた研究2013

    • Author(s)
      河口泰之、近藤英司、小野寺純、北村信人、八木知徳、安田和則
    • Organizer
      第125回北海道整形災害外科学会
    • Place of Presentation
      北海道大学学術交流会館、札幌市
    • Related Report
      2013 Research-status Report
  • [Presentation] 遺残組織の温存が解剖学的2束前十字靭帯再建術の成績に与える効果-臨床検査および再鏡視による定量的評価2013

    • Author(s)
      近藤英司、安田和則、北村信人、小野寺純、河口泰之、横田正司、甲斐秀顯、今淵隆誠、福井孝明、後藤佳子
    • Organizer
      第86回日本整形外科学会学術総会
    • Place of Presentation
      広島グリーンアリーナ、広島市
    • Related Report
      2013 Research-status Report
  • [Presentation] 膝屈筋腱ハイブリッド代用材料を用いた解剖学的2束ACL再建術2013

    • Author(s)
      近藤英司、北村信人、安田和則
    • Organizer
      第86回日本整形外科学会学術総会
    • Place of Presentation
      広島グリーンアリーナ、広島市
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] Effects of Remnant Ligament Tissue Preservation on The Clinical Outcome after Anatomic Double-bundle Anterior Cruciate Ligament Reconstruction: One year Follow-up and Second-look Arthroscopic Evaluations2013

    • Author(s)
      Kondo E, Onodera J, Kawaguchi Y, Kitamura N, Yagi T, Yasuda K
    • Organizer
      9th Biennial International Society of Arthroscopy, Knee Surgery and Orthopaedic Sports Medicine
    • Place of Presentation
      Metro Toronto Convention Centre, Toronto, Canada
    • Related Report
      2013 Research-status Report
  • [Presentation] Deficiency of macrophage migration inhibitory factor gene delays healing of the achilles tendon: a biomechanical and biological study2013

    • Author(s)
      Kondo E, Onodera S, Fujiki H, Yasuda K
    • Organizer
      The 59th Annual Meeting of the Orthopaedic Research Society
    • Place of Presentation
      Henry B. Gonzalez Convention Center (USA)
    • Related Report
      2012 Research-status Report
  • [Presentation] 解剖学的2重束前十字靭帯再建術の現状と未来2012

    • Author(s)
      近藤英司、北村信人、安田和則
    • Organizer
      第40回日本関節病学会
    • Place of Presentation
      鹿児島市民文化ホール(鹿児島県)
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] 解剖学的2重束前十字靱帯再建術の現状と課題2012

    • Author(s)
      近藤英司、安田和則、北村信人
    • Organizer
      第38回日本整形外科スポーツ医学会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] 変形性膝関節症における膝後十字靭帯前外側および後内側線維束の力学的特性2012

    • Author(s)
      小野寺純、近藤英司、安田和則、大水信幸、上田大輔、八木知徳
    • Organizer
      第39回日本臨床バイオメカニクス学会
    • Place of Presentation
      幕張メッセ国際会議場(千葉県)
    • Related Report
      2012 Research-status Report
  • [Presentation] Medial opening-wedge HTOにおいて用いる人工骨の臨床評価:ハイドロキシアパタイvs.β-リン酸三カルシウム2012

    • Author(s)
      小野寺純、近藤英司、安田和則、八木知徳
    • Organizer
      第40回日本関節病学会
    • Place of Presentation
      鹿児島市民文化ホール(鹿児島県)
    • Related Report
      2012 Research-status Report
  • [Presentation] マクロファージ遊走阻止因子遺伝子の欠損がアキレス腱の損傷治癒過程に与える影響2012

    • Author(s)
      近藤英司、藤木裕行、小野寺伸、安田和則
    • Organizer
      第27回日本整形外科学会基礎学術集会
    • Place of Presentation
      名古屋国際会議場(愛知県)
    • Related Report
      2012 Research-status Report
  • [Presentation] Biomechanical and clinical evaluations of anatomic double-bundle ACL reconstruction

    • Author(s)
      Kondo E
    • Organizer
      The 11th KOREA-JAPAN Joint Meeting of Orthopedic Sports Medicine
    • Place of Presentation
      Seoul St. Mary’s Hospital (Korea)
    • Related Report
      2012 Research-status Report
    • Invited
  • [Book] Sports Injuries: Prevention, Diagnosis, Treatment and Rehabilitation2014

    • Author(s)
      Kondo E, Yasuda K.
    • Total Pages
      13
    • Publisher
      Springer
    • Related Report
      2014 Annual Research Report
  • [Book] 越智光編:膝靱帯手術のすべて VIII 靱帯再建後再断裂に対するRevision Surgery 再再建術と私のポイント.2013

    • Author(s)
      近藤英司、安田和則
    • Total Pages
      5
    • Publisher
      メジカルビュー
    • Related Report
      2012 Research-status Report
  • [Book] 膝前十字靱帯再腱術―最新の治療戦略― 遺残組織を温存させた解剖学的2重束前十字靱帯再腱術―断裂遺残組織を温存したdouble-bundle reconstruction2013

    • Author(s)
      近藤英司、安田和則
    • Total Pages
      6
    • Publisher
      整形外科最小侵襲手術ジャーナル
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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