REGENERATION OF A RABBIT TIBIA BONE USING A NEW BONE SUBSITUTE MATERIALACTIVATING OSTEOBLAST CELL
| Project/Area Number |
24592219
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Tohoku University |
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Principal Investigator |
NAOHISA miyatake 東北大学, 歯学研究科(研究院), 大学院非常勤講師 (60623155)
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| Co-Investigator(Kenkyū-buntansha) |
SUZUKI Osamu 東北大学, 大学院歯学研究科, 教授 (60374948)
IMAIZUMI Hideki 東北大学, 大学院歯学研究科, 大学院非常勤講師 (70250785)
ITOI Eiji 東北大学, 医学(系)研究科, 教授 (80193465)
HOSAKA Masami 東北大学, 医学(系)研究科, 講師 (90302124)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | リン酸オクタカルシウム / ゼラチン / 骨置換能 / 材料吸収性 / リン酸カルシウム / 人工骨 / ウサギ |
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| Outline of Final Research Achievements |
This study was designed to investigate whether an octacalcium phosphate/gelatin (OCP/Gel) composite can repair a defect created in rabbit tibia for 2, 4, 8 weeks. Histological histomorphometrical and microCT studies showed that implantation of OCP/Gel composite enhanced bone regeneration in the defect compared to other bone substitute materials such as hydroxyapatite and b-TCP. Furthermore, the results demonstrated that OCP/Gel composite was a highly bioderadable material in rabbit tibia. The present study suggests that the OCP/Gel composite is a bone substitute material in which the stimulatory capacity of OCP crystals in new bone formation can be expressed even in the defect of long bone.
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Report
(4 results)
Research Products
(11 results)
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[Journal Article] The role of an octacalcium phosphate in the re-formation of infraspinatus tendon insertion2015
Author(s)
Itoigawa Y, Suzuki O, Sano H, Anada T, Handa T, Hatta T, Kuwahara Y, Takahashi A, Ezoe Y, Kaneko K, Itoi E.
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Journal Title
Journal of Shoulder and Elbow Surgery
Volume: in press
Issue: 7
Pages: e175-e184
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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