Regulation of metastatic ability and proliferation ability of sarcoma cell by inhibition of inflammatory cytokine.
Project/Area Number |
24592227
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Orthopaedic surgery
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Research Institution | University of Toyama |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
KANAMORI Masahiko 富山大学, 大学院医学薬学研究部(医学), 教授 (20204547)
SUZUKI Kayo 富山大学, 大学病院, 医員 (20456388)
HORI Takeshi 富山大学, 大学病院, 医員 (30401847)
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Project Period (FY) |
2012-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2014: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
|
Keywords | 骨軟部腫瘍 / 炎症性サイトカイン / 転移機能 / 免疫機能 / 手術 / 軟部肉腫 / 免疫組織染色 / アポトーシス / パスウェイ解析 |
Outline of Final Research Achievements |
Both IL-12 and IL-18, for as candidate inflammatory cytokine concerned with a treatment of bone soft part sarcoma, were suggested by miRNA array. These results lead the following: 1) therapeutic addition depending on condition of tumor, 2) relationships between sarcoma cell and host environment, and 3) degradation of "accompaniment fastness" by tumor resection. Furthermore, we were able to do analysis of metastatic mechanisms by miRNA array at the same time. The metastatic formations is inhibited by regulations of migration ability, invasion ability of sarcoma cell, and adhesion ability to a vascular endothelial cells in low concentration of molecular target drug. On the other hand, the ability of sarcoma cells was inhibited in high concentration of molecular target drug. These results might contribute to the control of metastatic formation.
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Report
(4 results)
Research Products
(34 results)
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[Presentation] 転移性胸椎腫瘍の術前神経機能に影響を与える因子の検討2014
Author(s)
安田剛敏, 川口善治, 中野正人, 関 庄二, 堀 岳史, 鈴木賀代, 渡邉健太, 金森昌彦, 木村友厚
Organizer
第47回日本整形外科学会 骨・軟部腫瘍学術集会
Place of Presentation
大阪国際会議場(大阪市)
Year and Date
2014-07-17 – 2014-07-18
Related Report
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[Presentation] 腰椎に発生した骨原発悪性末梢神経鞘腫の1例2014
Author(s)
鈴木賀代, 安田剛敏, 堀 岳史, 渡邉健太, 金森昌彦, 木村友厚
Organizer
第47回日本整形外科学会 骨・軟部腫瘍学術集会
Place of Presentation
大阪国際会議場(大阪市)
Year and Date
2014-07-17 – 2014-07-18
Related Report
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[Presentation] 脂肪腫の治療成績と問題点2014
Author(s)
安田剛敏, 鈴木賀代, 渡邊健太, 堀 岳史, 金森昌彦, 木村友厚
Organizer
第122回中部日本整形外科災害外科学会
Place of Presentation
岡山コンベンションセンター(岡山市)
Year and Date
2014-04-11 – 2014-04-12
Related Report
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[Presentation] 四肢発症の神経鞘腫の治療成績と問題点2014
Author(s)
鈴木賀代, 安田剛敏, 渡邊健太, 堀 岳史, 金森昌彦, 木村友厚
Organizer
第122回中部日本整形外科災害外科学会
Place of Presentation
岡山コンベンションセンター(岡山市)
Year and Date
2014-04-11 – 2014-04-12
Related Report
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