• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Development of new adjuvant therapy using nanoparticles for malignant bone and soft tumors

Research Project

Project/Area Number 24592244
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Orthopaedic surgery
Research InstitutionKeio University

Principal Investigator

MORIOKA Hideo  慶應義塾大学, 医学部, 講師 (10230096)

Co-Investigator(Kenkyū-buntansha) SUSA Michiro  慶應義塾大学, 医学部, 助教 (90327560)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords悪性骨・軟部腫瘍 / 化学療法 / ナノ粒子 / 薬剤耐性 / 分子標的治療 / 肉腫 / 抗癌剤 / 希少がん / 骨・軟部腫瘍
Outline of Final Research Achievements

Improvements in surgical technique, chemotherapy, and radiotherapy have enhanced the prognosis of patients with malignant bone and soft tissue tumors, but have since reached a plateau in recent years. Novel approaches have been sought but with limited results. On the other hand, several varieties of nanoparticles, including multifunctional nanoparticles, are available that localize the biodistribution of conventional chemotherapeutics to the tumor site. Also, nanoparticles loaded with chemotherapeutic drugs have the ability to overcome drug resistance which is a major obstacle impeding the progress of the treatment. Multifunctional nanoparticles, which have the potential to further augment the bioavailability of drugs, are being actively investigated. The purpose of this study is to investigate in vitro and in vivo therapeutic effects of multifunctional nanoparticles in malignant bone and soft tissue tumors with drug resistance for current chemotherapy.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (31 results)

All 2015 2014 2013 2012 Other

All Journal Article (9 results) (of which Peer Reviewed: 7 results,  Open Access: 1 results) Presentation (20 results) Book (1 results) Remarks (1 results)

  • [Journal Article] MicroRNA expression and functional profiles of osteosarcoma.2014

    • Author(s)
      Kobayashi E, Satow R, Ono M, Masuda M, Honda K, Sakuma T, Kawai A, Morioka H, Toyama Y, Yamada T.
    • Journal Title

      Oncology

      Volume: 86(2): Issue: 2 Pages: 94-103

    • DOI

      10.1159/000357408

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] TNFα promotes osteosarcoma progression by maintaining tumor cells in an undifferentiated state.2013

    • Author(s)
      Mori T
    • Journal Title

      Oncogene

      Volume: Epub ahead of print Issue: 33 Pages: 4236-4241

    • DOI

      10.1038/onc.2013.545

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Deep infection in tumor endoprosthesis around the knee: a multi-institutional study by the Japanese musculoskeletal oncology group.2013

    • Author(s)
      Morii,T., Morioka,H., Ueda,T., Araki,N., Hashimoto,N., Kawai,A., Mochizuki,K., Ichimura,S.
    • Journal Title

      BMC Musculoskelet Disord.

      Volume: 31 Issue: 1 Pages: 1-9

    • DOI

      10.1186/1471-2474-14-51

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Twist2 functions as a tumor suppressor in murine osteosarcoma cells.2013

    • Author(s)
      Ishikawa T, Shimizu T, Ueki A, Yamaguchi S, Onishi N, Sugihara E, Kuninaka S, Miyamoto T, Morioka H, Nakayama R, Kobayashi E, Toyama Y, Mabuchi Y, Matsuzaki Y, Yamaguchi R, Miyano S and Saya H
    • Journal Title

      Cancer Sci

      Volume: (in press) Issue: 7 Pages: 880-888

    • DOI

      10.1111/cas.12163

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Functional analysis of cases of tumor endoprostheses with deep infection around the knee: a multi institutional study by the Japanese Musculoskeletal Oncology Group (JMOG).2013

    • Author(s)
      Morii,T., Morioka,H., Ueda,T., Araki,N., Hashimoto,N., Kawai,A., Takeuchi,K., Anazawa,U., Mochizuki,K., Ichimura,S.
    • Journal Title

      Cancer Sci.

      Volume: 18 Issue: 4 Pages: 605-612

    • DOI

      10.1007/s00776-013-0389-y

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] An analysis of factors related to recurrence of myxofibrosarcoma2013

    • Author(s)
      Kikuta K,Kawai A
    • Journal Title

      Jpn J Clin Oncol

      Volume: 43(11) Issue: 11 Pages: 1093-104

    • DOI

      10.1093/jjco/hyt119

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Desmoplastic Fibroma Arising in the Distal Phalanx of the Great Toe: A Case Report.2013

    • Author(s)
      Koba,T., Susa,M., Nakayama,R., Watanabe,I., Horiuchi,K., Mukai,M., Yabe,H., Toyama,Y., Morioka,H.
    • Journal Title

      J Foot Ankle Surg.

      Volume: 53 Issue: 3 Pages: 71-74

    • DOI

      10.4081/rt.2013.e43

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] The germline TP53 mutation c.722 C>T promotes bone and liver tumorigenesis at a young age.2012

    • Author(s)
      Osumi,T., Miharu,M., Fuchimoto,Y., Morioka,H., Kosaki,K., Shimada,H.
    • Journal Title

      Pediatr Blood Cancer.

      Volume: 59 Pages: 1332-1333

    • Related Report
      2012 Research-status Report
  • [Journal Article] Detection of HEY1-NCOA2 fusion by fluorescence in-situ hybridization in formalin-fixed paraffin-embedded tissues as a possible diagnostic tool for mesenchymal chondrosarcoma.2012

    • Author(s)
      Nakayama R, Miura Y, Ogino J, Susa M, Watanabe I, Horiuchi K, Anazawa U, Toyama Y, Morioka H, Mukai M, Hasegawa T.
    • Journal Title

      Pathol Int.

      Volume: 62 Pages: 823-826

    • Related Report
      2012 Research-status Report
  • [Presentation] Stratified efficacy analysis and pharmacokinetic (PK) analysis of tarbectedin from a randomized phase II study comparing trabectedin and best supportive care (BSC) in patients (PTS) with translocation-related sarcomas (TRS).2014

    • Author(s)
      Takafumi,U., Takahashi,S., Araki,N., Sugiura,H., Yonemoto,T., Takahashi,M., Morioka,H., Hiruma,T., HIraga,H., Kunisada,T., Matsumine,A., Tanase,T., Kawai,A
    • Organizer
      Connective Tissue Oncology Society, 19th Annual Meeting.
    • Place of Presentation
      Berlin, Germany.
    • Year and Date
      2014-10-15 – 2014-10-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] PhaseⅡ study of eribulin mesylate in patients with advanced soft tissue sarcoma (STS).2014

    • Author(s)
      Naito,Y., Kawai,A., Araki,N., Ozaki,T., Sugiura,H., Yazawa,Y., Morioka,H., Matsumine,A., HIraiwa,M., Asami,S., Isu,K.
    • Organizer
      ASCO Annual Meeting.
    • Place of Presentation
      Chicago, USA.
    • Year and Date
      2014-05-29 – 2014-06-02
    • Related Report
      2014 Annual Research Report
  • [Presentation] Prognostic factors for high-grade soft tissue sarcomas (STS) in the extremities treated by perioperative chemotherapy with ifosfamide (IFO) and adriamycin (ADM): using the data from Japan Clinical Oncology Group trial (JCOG0304).2014

    • Author(s)
      Tanaka,K., Hasegawa,T., Mizusawa,J., Araki,N., Chuman,H., Takahashi,M., Ozaki,T., Hiruma,T., Tsuchiya,H., Morioka,H., Hatano,H., Wada,T., Hosaka,M., Yoshida,Y., Toguchida,J., Abe,S., Matsumine,A., Yokoyama,R., Fukuda,H., Iwamoto,Y.
    • Organizer
      ASCO Annual Meeting.
    • Place of Presentation
      Chicago, USA.
    • Year and Date
      2014-05-29 – 2014-06-02
    • Related Report
      2014 Annual Research Report
  • [Presentation] Limb salvage surgery for malignant bone tumor of extremities in children and adolescents: long-term follow-up.2014

    • Author(s)
      Susa,M., Watanabe,I., Nishimoto,K., Horiuchi,K., Anazawa,U., Suzuki,Y., Yabe,H., Toyama,Y., Morioka,H.
    • Organizer
      10th Asia Pacific Musculoskeletal Tumour Society Meeting.
    • Place of Presentation
      Melbourne, Australia.
    • Year and Date
      2014-04-09 – 2014-05-11
    • Related Report
      2014 Annual Research Report
  • [Presentation] Clinical results and prognostic factors in osteosarcoma with lung metastases.2014

    • Author(s)
      Nishimoto,K., Watanabe,I., Kikuta,K., Susa,M., Horiuchi,K., Suzuki,Y., Anazawa,U., Yabe,H., Kohno,M., Kawamura,M., Toyama,Y., Morioka,H.
    • Organizer
      10th Asia Pacific Musculoskeletal Tumour Society Meeting.
    • Place of Presentation
      Melbourne, Australia.
    • Year and Date
      2014-04-09 – 2014-04-11
    • Related Report
      2014 Annual Research Report
  • [Presentation] Autophagy inhibitions suppresses therapy-induced senescence and and enhances anti-tumor effects of cisplatin on osteosarcoma cells.2014

    • Author(s)
      Hirozane,T., Horiuchi,K., Mizuno,S., Mizuochi,H., Yoda,M., Tohmonda,T., Morioka,H., Toyama,Y.
    • Organizer
      10th Asia Pacific Musculoskeletal Tumour Society Meeting.
    • Place of Presentation
      Melbourne, Australia.
    • Year and Date
      2014-04-09 – 2014-04-11
    • Related Report
      2014 Annual Research Report
  • [Presentation] Clinical Outcome of Recurrent Myxofibrosarcoma.2013

    • Author(s)
      Nakayama,R., Kikuta,K., Susa,M., Kobayashi,E., Nakatani,F., Kawai,A., Chuman,H., Toyama,Y., Morioka,H.
    • Organizer
      26th European Musculoskeletal Oncology Society Meeting
    • Place of Presentation
      Gothenburg, Sweden
    • Related Report
      2013 Research-status Report
  • [Presentation] Custum-made ceramic spacer for children with osteosarcoma of lower extremities: a long follow-up.2013

    • Author(s)
      Nakatani,F., Nakayama,R., Asano,N., Kawai,A., Yamaguchi,U., Kobayashi,E., Y Tanzawa,Y., Ogura,K., Setsu,N., Fujiwara,T., Kubota,D., Watanabe,I., Susa,M., Morioka,H., Chuman,H.
    • Organizer
      International Society of Limb Salvage, 17th General Meeting.
    • Place of Presentation
      Bologna, Italia
    • Related Report
      2013 Research-status Report
  • [Presentation] Surgical treatment of chondrosarcoma of the chest wall.2013

    • Author(s)
      Susa,M., Nakayama,R., Watanabe,I., Horiuchi,K., Anazawa,U., Suzuki,Y., Yabe,H., Toyama,T., Morioka,H.
    • Organizer
      International Society of Limb Salvage, 17th General Meeting.
    • Place of Presentation
      Bologna, Italia
    • Related Report
      2013 Research-status Report
  • [Presentation] Clinical outcome of giant cell tumor of the mobile spine.2013

    • Author(s)
      Susa,M., Iwanami,A., Nakayama,R., Watanabe,I., Horiuchi,K., Anazawa,U., Suzuki,Y., Yabe,H., Matsumoto,M., Toyama,Y., Morioka,H.
    • Organizer
      International Society of Limb Salvage, 17th General Meeting.
    • Place of Presentation
      Bologna, Italia
    • Related Report
      2013 Research-status Report
  • [Presentation] Pathologic fracture in giant cell tumor: prognostic importance and treatment implications.2013

    • Author(s)
      Watanabe,I., Horiuchi,K., Nishimoto,K., Susa,M., Nakayama,R., Toyama,Y., Yabe,H., Morioka,H.
    • Organizer
      Connective Tissue Oncology Society, 18th Annual Meeting.
    • Place of Presentation
      New York, USA
    • Related Report
      2013 Research-status Report
  • [Presentation] Clinical outcome of primary malignant tumor of the mobile spine .2013

    • Author(s)
      Susa,M., Iwanami,A., Watanabe,I., Nishimoto,K., Horiuchi,K., Anazawa,U., Suzuki,Y., Yabe,H., Matsumoto,M., Toyama,Y., Morioka,H.
    • Organizer
      Connective Tissue Oncology Society, 18th Annual Meeting.
    • Place of Presentation
      New York, USA
    • Related Report
      2013 Research-status Report
  • [Presentation] Establishment of novel cell lines derived from sarcoma tissues.2013

    • Author(s)
      Horiuchi,K., Nakayama,R., Susa,M., Watanabe,I., Morioka,H.
    • Organizer
      Connective Tissue Oncology Society, 18th Annual Meeting.
    • Place of Presentation
      New York, USA
    • Related Report
      2013 Research-status Report
  • [Presentation] Epithelioid sarcoma: a clinicopathologic study of 44 cases.2013

    • Author(s)
      Asano,N., Yoshida,A., Ogura,K., Morioka,H., Mukai,M., Iwata,S., Ishii,T., Hiruma,T., Chuman,H., Kawai,A.
    • Organizer
      Connective Tissue Oncology Society, 18th Annual Meeting.
    • Place of Presentation
      New York, USA
    • Related Report
      2013 Research-status Report
  • [Presentation] A proteomic analysis to identify nevel proteins related to mechanisms of tumor cell invasion in myxofibrosarcoma.2013

    • Author(s)
      K.,Kikuta, D.,Kubota, Y.,Suzuki, H.,Morioka, Y.,Toyama, A.,Yoshida, E.,Kobayashi, F.,Nakatani, H.,Chuman, A.,Kawai, T.Kondo
    • Organizer
      The EuPA 2013 Scientific Meeting.
    • Place of Presentation
      Saint Malo, France
    • Related Report
      2013 Research-status Report
  • [Presentation] Surgical treatment of preadolescent osteosarcoma patients.2012

    • Author(s)
      Susa,M., Nakayama,R., Watanabe,I., Horiuchi,K., Anazawa,U., Suzuki,Y., Yabe,H., Toyama,Y., Morioka,H.
    • Organizer
      9th Asia Pacific Musculoskeletal Tumour Society Meeting
    • Place of Presentation
      Kuala Lumpur
    • Related Report
      2012 Research-status Report
  • [Presentation] Clinical outcome of recurrent myxofibrosarcoma.2012

    • Author(s)
      Nakayama,R., Kikuta,K., Susa,M., Watanabe,I., Horiuchi,K., Suzuki,Y., Anazawa,U., Yabe,H., Toyama,Y., Morioka,H.
    • Organizer
      9th Asia Pacific Musculoskeletal Tumour Society Meeting
    • Place of Presentation
      Kuala Lumpur
    • Related Report
      2012 Research-status Report
  • [Presentation] Detection of HEY1-NCOA2 fusion by fluorescence in situ hybridization in formalin-fixed, paraffin-embedded tissues as a possible defining diagnostic tool in mesenchymal chondrosarcoma.2012

    • Author(s)
      Nakayama,R., Ogino,J., Susa,M., Watanabe,I., Horiuchi,K., Anazawa,U., Toyama,Y., Morioka,H., Mukai,M., Hasegawa,T.
    • Organizer
      9th Asia Pacific Musculoskeletal Tumour Society Meeting
    • Place of Presentation
      Kuala Lumpur
    • Related Report
      2012 Research-status Report
  • [Presentation] Treatment of tibial adamantinoma; a study of 4 cases.2012

    • Author(s)
      Mori,T., Nakayama,R., Susa,M., Watanabe,I., Horiuchi,K., Yabe,H., Toyama,Y., Morioka,H.
    • Organizer
      9th Asia Pacific Musculoskeletal Tumour Society Meeting
    • Place of Presentation
      Kuala Lumpur
    • Related Report
      2012 Research-status Report
  • [Presentation] 17th Connective Tissue Oncology Society Annual Meeting2012

    • Author(s)
      Kobayashi,E., Sato,R., Kawai,A., Morioka,H., Toyama,Y., Yamada,T.: MicroRNA expression and functional profiles of osteosarcoma.
    • Organizer
      17th Connective Tissue Oncology Society Annual Meeting
    • Place of Presentation
      Prague
    • Related Report
      2012 Research-status Report
  • [Book] 肉腫化学療法マスタークラス2015

    • Author(s)
      森岡秀夫
    • Total Pages
      6
    • Publisher
      南山堂
    • Related Report
      2014 Annual Research Report
  • [Remarks] 慶應義塾大学医学部整形外科学教室 腫瘍班

    • URL

      http://www.keio-mog.jp/

    • Related Report
      2012 Research-status Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi