DNA double strand break and fusion gene formation in tumorigenesis of sarcoma.
| Project/Area Number |
24592250
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | National Hospital Organization, Kyushu Cancer Center |
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Principal Investigator |
TANAKA Kazuhiro 独立行政法人国立病院機構(九州がんセンター臨床研究センター), その他部局等, 客員研究員 (10274458)
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| Co-Investigator(Kenkyū-buntansha) |
ODA Shinya 独立行政法人国立病院機構九州がんセンター, 臨床研究センター, 腫瘍遺伝学研究室長 (40333372)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 肉腫 / 骨軟部腫瘍 / 染色体転座 / DNA修復 / 癌 |
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| Outline of Final Research Achievements |
Using DNA microarray approaches, expression of the genes functioning in DNA double strand break (DSB) repair was explored in cell lines or tissue specimens derived from Ewing sarcomas and the other human soft tissue neoplasms with disease-specific chromosomal translocations. Expression of several DSB repair genes was similarly induced in these sarcoma cells. Furthermore, expression and subcellular localization of the DSB repair proteins were observed using immunocytochemistry, the results revealing an enhanced nuclear foci-formation in some DSB repair factors, which strongly suggest that the induction of the genes does reflect functional responses to DSBs occurred in cells.
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Report
(4 results)
Research Products
(24 results)
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[Journal Article] Perioperative chemotherapy with high-dose ifosfamide and doxorubicin for high-grade soft tissue sarcomas in the extremities: Japan Clinical Oncology Group Study JCOG0304.2015
Author(s)
Tanaka K, Mizusawa J, Fukuda H, Araki N, Chuman H, Takahashi M, Ozaki T, Hiruma T, Tsuchiya H, Morioka H, Hatano H, Wada T, Hosaka M, Yoshida Y, Toguchida J, Abe S, Matsumine A, Yokoyama R, Iwamoto Y
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Journal Title
Jpn J Clin Oncol
Volume: 印刷中
Related Report
Peer Reviewed
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[Journal Article] A randomized phase II/III trial of perioperative chemotherapy with adriamycin plus ifosfamide vs gemcitabine plus docetaxel for high-grade soft tissue sarcoma: Japan Clinical Oncology Group study JCOG1306.2014
Author(s)
Kataoka K, Tanaka K, Mizusawa J, Kimura A, Hiraga H, Kawai A, Matsunobu T, Matsumine A, Araki N, Oda Y, Fukuda H, Iwamoto Y
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Journal Title
Jpn J Clin Oncol
Volume: 44
Issue: 8
Pages: 765-769
DOI
Related Report
Peer Reviewed
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[Presentation] Prognostic factors for high-grade soft tissue sarcomas (STS) in the extremities treated by perioperative chemotherapy with ifosfamide (IFO) and adriamycin (ADM): Using data from Japan Clinical Oncology Group trial (JCOG0304).2014
Author(s)
Tanaka K, Hasegawa T, Mizusawa J, Araki N, Chuman H, Takahashi M, Ozaki T, Hiruma T, Tsuchiya H, Morioka H, Hatano H, Wada T, Hosaka M, Yoshida Y, Toguchida J, Abe S, Matsumine A, Yokoyama K, Fukuda H, Iwamoto Y
Organizer
2014 Annual Meeting of American Society of Clinical Oncology
Place of Presentation
Chicago, USA
Year and Date
2014-05-30 – 2014-06-03
Related Report
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