| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
In order to elucidate microarchitecture and strength of human vertebral bone in the clinical setting, we have developed analytical system including morphometric analysis and finite element analysis using 3D information obtained by computed tomography. Effects of anti-resorptive and anabolic agents for primary osteoporosis were evaluated in vivo by using this system. Our results indicate that both anti-resorptive and anabolic agents can increase bone mass, positively alter trabecular microarchitecture, and improve the estimated bone strength. However, trabecular connectivity could not be restored by anti-resorptive treatment, and may only be improved by anabolic agent. Areal BMD measured by DXA may underestimate the change in bone mass, microarchitecture, and the strength.
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