Research on the prevention of osteonecrosis of the femoral head by analyzing genetic polymorphism
| Project/Area Number |
24592274
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
INOUE Shigehiro 京都府立医科大学, 医学(系)研究科(研究院), 准教授 (10184748)
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| Research Collaborator |
HAYASHI Shigeki 京都府立医科大学, 医学研究科
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 特発性大腿骨頭壊死症 / 遺伝子多型 / SNPs / tailor-made medicine |
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| Outline of Final Research Achievements |
The purpose of this study is to prevent steroid-induced osteonecrosis of the femoral head (ONFH) by analyzing genetic polymorphism. First, we made a short list of candidate gene by primary screening with microarray. Then, we tried to detect the gene related with the steroid-induced ONFH by analyzing the base sequence of the candidate gene and analyze the single nucleotide polymorphism (SNPs) of the candidate gene. We detected the SNPs related with steroid-induced ONFH, and analyzed the association with each SNPs. However, we cannot detect the new SNPs related with steroid-induced ONFH.
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Report
(4 results)
Research Products
(1 results)
