| Project/Area Number |
24592276
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Nara Medical University |
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Principal Investigator |
Kumai Tsukasa 奈良県立医科大学, 医学部, 教授 (40382288)
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| Co-Investigator(Kenkyū-buntansha) |
TANAKA Yasuhito 奈良県立医科大学, 医学部, 教授 (30316070)
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | enthesis / neural element / enthesis organ / neuropeptide / hyaluronic acid / nerve element / enthesopathy / nueropeptide |
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| Outline of Final Research Achievements |
To clarify the pathogenesis of the injury of the attachment of the tendon/ligament (i.e. enthesis), we investigated the nerve elements and angiogenesis, which might cause some symptoms, such as pain, and the repair reaction. We demonstrated that they were present at synovial adipose tissue around the enthesis (i.e. enthesis organ). In this study, Although the blood vessels increase strongly after the injury of the enthesis, it was unable to clear whether nerve elements react strongly. The administration of hyaluronic acid to the injury site of the enthesis, compared to the non-administration group, it was found that the repair response to injury occurs more rapidly (promoting action).
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