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Analysis of the role of TGF-b family and Smad signaling in musculoskeletal regulation

Research Project

Project/Area Number 24592278
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Orthopaedic surgery
Research InstitutionSaitama Medical University

Principal Investigator

YONEYAMA Katsumi  埼玉医科大学, 医学部, 助手 (20571574)

Co-Investigator(Kenkyū-buntansha) KATAGIRI Takenobu  埼玉医科大学, 医学部, 教授 (80245802)
Co-Investigator(Renkei-kenkyūsha) OHTE Satoshi  埼玉医科大学, 医学部, 助教 (00547979)
SASANUMA Hiroki  埼玉医科大学, 医学部, 研究員 (30571707)
MIYAMOTO Arei  埼玉医科大学, 医学部, 研究員 (70634591)
OSAWA Kenji  埼玉医科大学, 医学部, 助教 (70638238)
Research Collaborator TSUKAMOTO Sho  埼玉医科大学, 医学部 (20707658)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords転写因子 / 細胞内伝達情報 / 分化 / 骨格筋 / 運動器 / 細胞内情報伝達
Outline of Final Research Achievements

Transforming Growth Factor-β (TGF-β) family cytokines play crucial role for musculoskeletal development, regeneration and homeostasis. To clarify the molecular mechanisms of TGF-β family, we developed a mouse line carrying skeletal muscle-specific knockout of Smad4, which is an essential transcriptional factor for intracellular signaling of TGF-β family. Because the muscle-specific Smad4 KO mice were lethal, we prepared mononuclear cells from the skeletal muscle tissue of the Smad4 floxed mice and cultured them in vitro. A deletion of Smad4 in the cells by expression of Cre DNA recombinase in vitro stimulated differentiation into myocytes and myotubes, suggesting that Smad4 represses myogenesis in myoblasts. These findings suggest that the Smad4-dependent intracellular signaling of the TGF-β family plays an important role during skeletal muscle development. These findings may provide new therapeutic strategies for diseases caused by dysregulation of the TGF-β family signaling.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (59 results)

All 2014 2013 2012 Other

All Journal Article (17 results) (of which Peer Reviewed: 15 results,  Open Access: 2 results,  Acknowledgement Compliant: 2 results) Presentation (42 results) (of which Invited: 1 results)

  • [Journal Article] Smad9 is a new type of transcriptional regulator in bone morphogenetic protein signaling.2014

    • Author(s)
      Tsukamoto S, Mizuta T, Fujimoto M, Ohte S, Osawa K, Miyamoto A, Yoneyama K, Murata E, Machiya A, Jimi E, Kokabu S, Katagiri T.
    • Journal Title

      Scientific Reports

      Volume: 4 Issue: 1 Pages: 7596-7596

    • DOI

      10.1038/srep07596

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Establishment of a novel model of chondrogenesis using murine embryonic stem cells carrying fibrodysplasia ossificans progressiva-associated mutant ALK2.2014

    • Author(s)
      Fujimoto M, Ohte S, Shin M, Yoneyama K, Osawa K, Miyamoto A, Tsukamoto S, Mizuta T, Kokabu S, Machiya A, Okuda A, Suda N, Katagiri T.
    • Journal Title

      Biochmical and Biophysical Research Communications

      Volume: 455 Issue: 3-4 Pages: 347-352

    • DOI

      10.1016/j.bbrc.2014.11.012

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Expression of TLE3 by bone marrow stromal cells is regulated by canonical Wnt signaling2014

    • Author(s)
      Kokabu S, Sato T, Ohte S, Enoki Y, Okubo M, Katagiri T, Rosen V, Yoda T.
    • Journal Title

      Federation of European Biochemical Societies letters

      Volume: 588 Issue: 4 Pages: 614-619

    • DOI

      10.1016/j.febslet.2013.12.031

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] TGF-βファミリーから見える骨と筋の新しい接点2014

    • Author(s)
      片桐岳信、塚本翔、大澤賢次
    • Journal Title

      実験医学

      Volume: 32 Pages: 1010-1016

    • Related Report
      2013 Research-status Report
  • [Journal Article] The unique activity of bone morphogenetic proteins in bone: a critical role of the Smad signaling pathway2013

    • Author(s)
      Katagiri T, Tsukamoto S.
    • Journal Title

      Biological Chemistry

      Volume: 394 Issue: 6 Pages: 703-714

    • DOI

      10.1515/hsz-2012-0310

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] TLE3, transducing-like enhancer of split 3, suppresses osteoblast differentiation of bone marrow stromal cells2013

    • Author(s)
      Kokabu S, Nguyen T, Ohte S, Sato T, Katagiri T, Yoda T, Rosen V.
    • Journal Title

      Biochemical and biophysical research communications

      Volume: 438 Issue: 1 Pages: 205-210

    • DOI

      10.1016/j.bbrc.2013.07.054

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] 進行性骨化性線維異形成症(FOP)2013

    • Author(s)
      片桐岳信
    • Journal Title

      Bone Joint Nerve

      Volume: 3 Pages: 53-60

    • Related Report
      2013 Research-status Report
  • [Journal Article] Identification of a novel bone morphogenetic protein (BMP)-inducible transcript, BMP-inducible transcript-1, by utilizing the conserved BMP-responsive elements in the Id genes.2013

    • Author(s)
      Shin M, Ohte S, Fukuda T, Sasanuma H, Yoneyama K, Kokabu S, Miyamoto A. Tsukamoto S, Hohjoh H, Jimi E, Katagiri T.
    • Journal Title

      J Bone Miner Metab.

      Volume: 31 Issue: 1 Pages: 34-43

    • DOI

      10.1007/s00774-012-0381-1

    • NAID

      10031168835

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Clinically applicable antianginal agents suppress osteoblastic transformation of myogenic cells and heterotopic ossifications in mice2013

    • Author(s)
      Yamamoto R, Matsushita M, Kitoh H, Masuda A, Ito M, Katagiri T, Kawai T, Ishiguro N, Ohno K
    • Journal Title

      J Bone Miner Metab

      Volume: 31 Pages: 26-33

    • DOI

      10.1007/s00774-012-0380-2

    • NAID

      10031168834

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Identification and functional analysis of Zranb2 as a novel Smad-binding protein that suppresses BMP signaling2012

    • Author(s)
      Ohte S
    • Journal Title

      J Cell Biochem

      Volume: 113 Issue: 3 Pages: 808-814

    • DOI

      10.1002/jcb.23408

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Trichocyalides A and B, new inhibitors of alkaline phosphatase activity in bone morphogenetic protein-stimulated myoblasts, produced by Trichoderma sp. FKI-55132012

    • Author(s)
      Fukuda T, Uchida R, Ohte S, Inoue H, Yamazaki H, Matsuda D, Nonaka K, Masuma R, Katagiri T, Tomoda H.
    • Journal Title

      The Journal of antibiotics (Tokyo)

      Volume: 65 Issue: 11 Pages: 565-569

    • DOI

      10.1038/ja.2012.70

    • NAID

      10031126917

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Fungal pyrrolidine-containing metabolites inhibit alkaline phosphatase activity in bone morphogenetic protein-stimulated myoblastoma cells.2012

    • Author(s)
      Fukuda T, Uchida R, Inoue H, Ohte S, Yamazaki Y, Matsuda D, Katagiri T, Tomoda H.
    • Journal Title

      Acta Pharmaceutica Sinica B

      Volume: 2 Pages: 23-27

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Disease-causing allele specific silencing against the ALK2 mutants, R206H and G356D, in Fibrodysplasia Ossificans Progressiva2012

    • Author(s)
      Takahashi M
    • Journal Title

      Gene Ther

      Volume: 31 Issue: 7 Pages: 3019-3028

    • DOI

      10.1038/gt.2011.193

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Role of osteoglycin in the linkage between muscle and bone2012

    • Author(s)
      Tanaka K, Matsumoto E, Higashimaki E, Katagiri T, Sugimoto T, Seino S, Kaji H
    • Journal Title

      J Biol Chem

      Volume: 287 Issue: 15 Pages: 11616-11628

    • DOI

      10.1074/jbc.m111.292193

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Accumulation of p100, a precursor of NF-κB2, enhances osteoblastic differentiation in vitro and bone formation in vivo in aly/aly mice2012

    • Author(s)
      Seo Y
    • Journal Title

      Mol Endocrinol

      Volume: 26 Issue: 3 Pages: 414-422

    • DOI

      10.1210/me.2011-1241

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Ubc9 negatively regulates BMP-mediated osteoblastic differentiation in cultured cells2012

    • Author(s)
      Yukita A, Hosoya A, Ito Y, Katagiri T, Asashima M, Nakamura H
    • Journal Title

      Bone

      Volume: 50 Issue: 5 Pages: 1092

    • DOI

      10.1016/j.bone.2012.02.008

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] BMP3 suppresses osteoblast differentiation of bone marrow stromal cells via interaction with Acvr2b2012

    • Author(s)
      Kokabu S
    • Journal Title

      Mol Endocrinol

      Volume: 26 Issue: 1 Pages: 87-94

    • DOI

      10.1210/me.2011-1168

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] Smad9 is a new type of transcriptional repressor in BMP signaling.2014

    • Author(s)
      Tsukamoto S, Mizuta T, Fujimoto M, Ohte S, Osawa K, Miyamoto A, Yoneyama K, Murata E, Jimi E, Kokabu S, Katagiri T.
    • Organizer
      The 12th RCGM International Symposium of Academic Frontier
    • Place of Presentation
      埼玉医科大学30周年記念講堂(埼玉県日高市)
    • Year and Date
      2014-10-31 – 2014-11-01
    • Related Report
      2014 Annual Research Report
  • [Presentation] Chondrogenic differentiation of murine embryonic stem cells carrying an active form of ALK2.2014

    • Author(s)
      Fujimoto M, Ohte S, Shin M, Yoneyama K, Mizuta T, Osawa K, Tsukamoto S, Miyamoto A, Okuda A, Suda N, Katagiri T.
    • Organizer
      The 12th RCGM International Symposium of Academic Frontier
    • Place of Presentation
      埼玉医科大学30周年記念講堂(埼玉県日高市)
    • Year and Date
      2014-10-31 – 2014-11-01
    • Related Report
      2014 Annual Research Report
  • [Presentation] Smad8 is a novel regulator of BMP signaling.2014

    • Author(s)
      Tsukamoto S, Mizuta T, Fujimoto M, Ohte S, Osawa K, Miyamoto A, Yoneyama K, Murata E, Jimi E, Kokabu S, Katagiri T.
    • Organizer
      10th International BMP Conference
    • Place of Presentation
      ベルリン(ドイツ)
    • Year and Date
      2014-09-16 – 2014-09-20
    • Related Report
      2014 Annual Research Report
  • [Presentation] Smad8 negatively regulates BMP signaling in a dominant negative fashion.2014

    • Author(s)
      Tsukamoto S, Mizuta T, Fujimoto M, Ohte S, Osawa K, Miyamoto A, Yoneyama K, Murata E, Jimi E, Kokabu S, Katagiri T.
    • Organizer
      2014 ASBMR Annual Meeting
    • Place of Presentation
      ヒューストン(アメリカ)
    • Year and Date
      2014-09-12 – 2014-09-15
    • Related Report
      2014 Annual Research Report
  • [Presentation] Establishment and characterization of a novel Tet-Off embryonic stem cell lines carrying ALK2.2014

    • Author(s)
      Fujimoto M, Ohte S, Shin M, Yoneyama K, Osawa K, Tsukamoto S, Miyamoto A, Mizuta T, Kokabu S, Okuda A, Suda N, Katagiri T.
    • Organizer
      2014 ASBMR Annual Meeting
    • Place of Presentation
      ヒューストン(アメリカ)
    • Year and Date
      2014-09-12 – 2014-09-15
    • Related Report
      2014 Annual Research Report
  • [Presentation] Smad8による新たなBMPシグナルの制御機構2014

    • Author(s)
      塚本翔、水田誉人、藤本舞、大手聡、大澤賢次、宮本阿礼、米山克美、村田栄子、自見英治郎、古株彰一郎、片桐岳信
    • Organizer
      第21回BMP研究会
    • Place of Presentation
      大阪大学中之島センターメモリアルホール(大阪府大阪市)
    • Year and Date
      2014-07-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] A novel regulation of BMP signaling by Smad8.2014

    • Author(s)
      Tsukamoto S, Mizuta T, Fujimoto M, Ohte S, Osawa K, Miyamoto A, Yoneyama K, Murata E, Jimi E, Kokabu S, Katagiri T.
    • Organizer
      FASEB Science Research Conferences Skeletal Muscle Satellite and Stem Cells
    • Place of Presentation
      スティームボート・スプリングズ(アメリカ)
    • Year and Date
      2014-07-20 – 2014-07-25
    • Related Report
      2014 Annual Research Report
  • [Presentation] stablishment of a novel model for chondrogenic differentiation using murine embryonic stem cells carrying mutant ALK2.2014

    • Author(s)
      Fujimoto M, Ohte S, Shin M, Yoneyama K, Osawa K, Tsukamoto S, Miyamoto A, Mizuta T, Kokabu S, Okuda A, Suda N, Katagiri T.
    • Organizer
      FASEB Science Research Conferences Skeletal Muscle Satellite and Stem Cells
    • Place of Presentation
      スティームボート・スプリングズ(アメリカ)
    • Year and Date
      2014-07-20 – 2014-07-25
    • Related Report
      2014 Annual Research Report
  • [Presentation] Mutant ALK2 receptors identified in patients with a typical and a variant fibrodysplasia ossificans progressiva show different sensitivities to type II receptors2013

    • Author(s)
      Mai Fujimoto, Satoshi Ohte, Sho Tsukamoto, Arei Miyamoto, Naoto Suda, Takenobu Katagiri
    • Organizer
      2nd Joint Meeting of the international Bone and Mineral Society and The Japanese Society for Bone and Mineral Research
    • Place of Presentation
      神戸
    • Related Report
      2013 Research-status Report
  • [Presentation] Smad8はBMPシグナルを抑制的に調節する2013

    • Author(s)
      片桐岳信、藤本舞、古株彰一郎、自見英治郎、大澤賢次
    • Organizer
      第55回歯科基礎医学会学術大会・総会
    • Place of Presentation
      岡山
    • Related Report
      2013 Research-status Report
  • [Presentation] 進行性骨化性線維異形成症から同定された 2 種類の ALK2 変異体は II 型受容体に対する感受性が異なる2013

    • Author(s)
      藤本舞、大澤賢次、古株彰一郎、須田直人、片桐岳信
    • Organizer
      第55回歯科基礎医学会学術大会・総会
    • Place of Presentation
      岡山
    • Related Report
      2013 Research-status Report
  • [Presentation] Smad8 is a Novel Type Regulator of BMP Signaling2013

    • Author(s)
      Sho Tsukamoto, Satoshi Ohte, Mai Fujimoto, Takato Mizuta, Arei Miyamoto, Kenji Osawa, Shoichiro Kokabu, Eiko Murata, Eijiro Jimi, Takenobu Katagiri
    • Organizer
      2013 ASBMR Annual Meeting
    • Place of Presentation
      Baltimore Convention Center ( アメリカ )
    • Related Report
      2013 Research-status Report
  • [Presentation] Mutant ALK2 receptors identified in patients with typical and variant cases of fibrodysplasia ossificans progressiva are activated through phosphorylation at Thr203 by different BMP type II receptors2013

    • Author(s)
      Mai Fujimoto, Satoshi Ohte, Arei Miyamoto, Sho Tsukamoto, Kenji Osawa, Takato Mizuta, Shoichiro Kokabu, Naoto Suda, Takenobu Katagiri
    • Organizer
      2013 ASBMR Annual Meeting
    • Place of Presentation
      Baltimore Convention Center ( アメリカ )
    • Related Report
      2013 Research-status Report
  • [Presentation] 典型的および非典型的な進行性骨化性線維異形成症例から同定された変異ALK2の機能解析2013

    • Author(s)
      藤本舞、片桐岳信、須田直人
    • Organizer
      第72回日本矯正歯科学会大会
    • Place of Presentation
      長野
    • Related Report
      2013 Research-status Report
  • [Presentation] 転写因子Smad8によるBMPシグナル調節機構の解明2013

    • Author(s)
      塚本翔、水田誉人、大澤賢次、藤本舞、宮本阿礼、片桐岳信
    • Organizer
      第11回RCGMフロンティアシンポジウム
    • Place of Presentation
      埼玉
    • Related Report
      2013 Research-status Report
  • [Presentation] TGF-βのI型受容体における活性化機序の解析2013

    • Author(s)
      水田誉人、塚本翔、藤本舞、宮本阿礼、大澤賢次、片桐岳信
    • Organizer
      第11回RCGMフロンティアシンポジウム
    • Place of Presentation
      埼玉
    • Related Report
      2013 Research-status Report
  • [Presentation] 進行性骨化性線維異形成症(FOP)におけるALK2変異体の活性化メカニズムの解析2013

    • Author(s)
      藤本舞、塚本翔、大澤賢次、宮本阿礼、水田誉人、須田直人、片桐岳信
    • Organizer
      第11回RCGMフロンティアシンポジウム
    • Place of Presentation
      埼玉
    • Related Report
      2013 Research-status Report
  • [Presentation] FOPの変異ALK2は異所性骨化を誘導する2013

    • Author(s)
      大澤賢次、宮本阿礼、塚本翔、藤本舞、水田誉人、片桐岳信
    • Organizer
      第11回RCGMフロンティアシンポジウム
    • Place of Presentation
      埼玉
    • Related Report
      2013 Research-status Report
  • [Presentation] マウス骨格筋由来細胞によるALK2(R206H)の新しい解析法の樹立2013

    • Author(s)
      宮本阿礼、大澤賢次、塚本翔、藤本舞、水田誉人、片桐岳信
    • Organizer
      第11回RCGMフロンティアシンポジウム
    • Place of Presentation
      埼玉
    • Related Report
      2013 Research-status Report
  • [Presentation] BMP 受容体 ALK2 の Tet-ON 誘導システムによる発現細胞の樹立2012

    • Author(s)
      米山克美、塚本翔、大手聡、笹沼寛樹、進正史、藤本舞、片桐岳信
    • Organizer
      第30回日本骨代謝学会学術集会
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
  • [Presentation] BMP および TGF-b 特異的シグナルを伝達する構成的活性型Smadの解析2012

    • Author(s)
      塚本翔、大手聡、米山克美、藤本舞、進正史、笹沼寛樹、自見英治郎、片桐岳信
    • Organizer
      第30回日本骨代謝学会学術集会
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
  • [Presentation] I 型 BMP 受容体 ALK2 の活性化には II 型 BMP 受容体による GS ドメイン内 Thr203 のリン酸化が必須である2012

    • Author(s)
      大手聡、藤本舞、米山克美、笹沼寛樹、進正史、塚本翔、福田亨、古株彰一郎、片桐岳信
    • Organizer
      第30回日本骨代謝学会学術集会
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
  • [Presentation] Id 遺伝子の BMP 応答領域の解析に基づく新規 BMP 応答性転写産物の同定2012

    • Author(s)
      片桐岳信、進正史、大手聡、福田亨、笹沼寛樹、米山克美、古株彰一郎、宮本阿礼、塚本翔、自見英治郎
    • Organizer
      第30回日本骨代謝学会学術集会
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
  • [Presentation] Molecular Mechanisms of Activation of Mutant ALK2 in FOP2012

    • Author(s)
      Satoshi Ohte, Mai Fujimoto, Sho Tsukamoto, Arei Miyamoto, Hiroki Sasanuma, Masashi Shin, Katsumi Yoneyama, Toru Fukuda, Shoichiro Kokabu, Takenobu Katagiri
    • Organizer
      International conference on bone morphogenetic protein
    • Place of Presentation
      カリフォルニア(アメリカ)
    • Related Report
      2012 Research-status Report
  • [Presentation] 成熟骨芽細胞をモニターできる新しい蛍光タンパク質レポーターシステムの開発2012

    • Author(s)
      曽根岳史、進正史、笹沼寛樹、大手聡、片桐岳信、三谷幸之介
    • Organizer
      第30回日本骨代謝学会学術集会
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
  • [Presentation] 進行性骨化性線維異形成症における変異型 BMP 受容体 ALK2 の活性化機構2012

    • Author(s)
      大手聡、藤本舞、米山克美、笹沼寛樹、進正史、塚本翔、宮本阿礼、福田亨、古株彰一郎、片桐岳信
    • Organizer
      第19回BMP研究会
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
  • [Presentation] リガンド特異的シグナル伝達をする構成的活性型 Smad の解析2012

    • Author(s)
      塚本翔、大手聡、米山克美、笹沼寛樹、藤本舞、宮本阿礼、片桐岳信
    • Organizer
      第19回BMP研究会
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
  • [Presentation] Activation mechanisms of mutant ALK2 found in fibrodysplasia ossificans progressiva by type II BMP receptor2012

    • Author(s)
      Satohi Ohte, Mai Fujimoto, Sho Tsukamoto, Arei Miyamoto, Hiroki Sasanuma, Masashi Shin, Katsumi Yoneyama, Toru Fukuda, Shoichiro Kokabu, Takenobu Katagiri
    • Organizer
      1st asia-pacific bone and mineral research meeting
    • Place of Presentation
      パース(オーストラリア)
    • Related Report
      2012 Research-status Report
  • [Presentation] 進行性骨化性線維異形成症から同定された新規 ALK2 変異体の機能解析2012

    • Author(s)
      藤本舞、須田直人、片桐岳信
    • Organizer
      第54回歯科基礎医学会学術大会・総会
    • Place of Presentation
      福島
    • Related Report
      2012 Research-status Report
  • [Presentation] 変異型 Smad1/5/8 を用いた BMP 細胞内シグナルの解析2012

    • Author(s)
      片桐岳信
    • Organizer
      第54回歯科基礎医学会学術大会・総会
    • Place of Presentation
      福島
    • Related Report
      2012 Research-status Report
  • [Presentation] Critical Role of ALK2 Phosphorylation at Thr203 in Activation by BMP type II Receptors2012

    • Author(s)
      Satohi Ohte, Mai Fujimoto, Katsumi Yoneyama, Hiroki Sasanuma, Masashi Shin, Sho Tsukamoto, Arei Miyamoto, Toru Fukuda, Shoichiro Kokabu, Takenobu Katagiri
    • Organizer
      2012 ASBMR Annual Meeting
    • Place of Presentation
      ミネアポリス(アメリカ)
    • Related Report
      2012 Research-status Report
  • [Presentation] Identification of a Novel BMP-inducible Transcript, BIT-1, by Utilizing the Conserved BMP-Responsive Elements in the Id Genes2012

    • Author(s)
      Masashi Shin, Satoshi Ohte, Toru Fukuda, Hiroki Sasanuma, Katsumi Yoneyama, Shoichiro Kokabu, Sho Tsukamoto, Hirohoko Hohjoh, Eijiro Jimi, Takenobu Katagiri
    • Organizer
      2012 ASBMR Annual Meeting
    • Place of Presentation
      ミネアポリス(アメリカ)
    • Related Report
      2012 Research-status Report
  • [Presentation] Linker regions of Smad1/5/8 regulate bone-inducing activity of BMPs2012

    • Author(s)
      Sho Tsukamoto, Satoshi Ohte, Katsumi Yoneyama, Mai Fujimoto, Arei Miyamoto, Eiko Murata, Eijiro Jimi, Takenobu Katagiri
    • Organizer
      2012 ASBMR Annual Meeting
    • Place of Presentation
      ミネアポリス(アメリカ)
    • Related Report
      2012 Research-status Report
  • [Presentation] Establishmrent and analysis of Dox-inducible ALK2-expressiong C2C12 cell lines2012

    • Author(s)
      Katsumi Yoneyama, Sho Tsukamoto, Satoshi Ohte, Hiroki Sasanuma, Mai Fujimoto, Arei Miyamoto, Takenobu Katagiri
    • Organizer
      第10回RCGMフロンティアシンポジウム
    • Place of Presentation
      埼玉
    • Related Report
      2012 Research-status Report
  • [Presentation] A role of satellite cells in heterotopic bone formation in skeletal muscle induced by BMP signaling2012

    • Author(s)
      Hiroki Sasanuma, Katsumi Yoneyama, Satoshi Ohte, Sho Tsukamoto, Mai Fujimoto, Arei Miyamoto, Takenobu Katagiri
    • Organizer
      第10回RCGMフロンティアシンポジウム
    • Place of Presentation
      埼玉
    • Related Report
      2012 Research-status Report
  • [Presentation] Analysis of intracellular signaling pathway important for heterotopic bone-induction by BMPs2012

    • Author(s)
      Sho Tsukamoto, Satoshi Ohte, Katsumi Yoneyama, Mai Fujimoto, Hiroki Sasanuma, Arei Miyamoto, Takenobu Katagiri
    • Organizer
      第10回RCGMフロンティアシンポジウム
    • Place of Presentation
      埼玉
    • Related Report
      2012 Research-status Report
  • [Presentation] Thr203 in ALK2 is a critical residue for activation by BMP type II receptors.2012

    • Author(s)
      Satoshi Ohte, Mai Fujimoto, Katsumi Yoneyama, Hiroki Sasanuma, Sho Tsukamoto, Arei Miyamoto, Shoichiro Kokabu, Takenobu Katagiri
    • Organizer
      第10回RCGMフロンティアシンポジウム
    • Place of Presentation
      埼玉
    • Related Report
      2012 Research-status Report
  • [Presentation] Functional analysis of novel ALK2 mutant identified in fibrodyaplasia ossificans progressiva.2012

    • Author(s)
      Mai Fujimoto, Satoshi Ohte, Katsumi Yoneyama, Hiroki Sasanuma, Sho Tsukamoto, Arei Miyamoto, Naoto Suda, Takenobu Katagiri
    • Organizer
      第10回RCGMフロンティアシンポジウム
    • Place of Presentation
      埼玉
    • Related Report
      2012 Research-status Report
  • [Presentation] Identification of novel BMP-inducible transcript, BIT-1, by utilizing the conserved BMP-responsive elements in the id genes2012

    • Author(s)
      Arei Miyamoto, Masashi Shin, Satoshi Ohte, Hiroki Sasanuma, Katsumi Yoneyama, Shoichiro Kokabu, Sho Tsukamoto, Takenobu Katagiri
    • Organizer
      第10回RCGMフロンティアシンポジウム
    • Place of Presentation
      埼玉
    • Related Report
      2012 Research-status Report
  • [Presentation] 進行性骨化性線維異形成症の典型症例および亜型症例から同定されたALK2受容体はII型受容体に対する感受性が異なる

    • Author(s)
      藤本舞、大手聡、塚本翔、宮本阿礼、古株彰一郎、須田直人、片桐岳信
    • Organizer
      第31回日本骨代謝学会学術集会
    • Place of Presentation
      神戸
    • Related Report
      2013 Research-status Report
  • [Presentation] 非典型的な進行性骨化性線維異形成症で見出されたALK2変異体の解析

    • Author(s)
      藤本舞、大手聡、塚本翔、宮本阿礼、古株彰一郎、大澤賢次、須田直人、片桐岳信
    • Organizer
      第20回BMP研究会
    • Place of Presentation
      浜松
    • Related Report
      2013 Research-status Report
  • [Presentation] Smad8 is a Novel Type Regulator of BMP Signaling

    • Author(s)
      Sho Tsukamoto, Satoshi Ohte, Mai Fujimoto, Takato Mizuta, Arei Miyamoto, Kenji Osawa, Shoichiro Kokabu, Eiko Murata, Eijiro Jimi, Takenobu Katagiri
    • Organizer
      2013 ASBMR Symposium Cutting Edge Discoveries in Muscle Biology, Disease and Therapeutics
    • Place of Presentation
      Baltimore Convention Center ( アメリカ )
    • Related Report
      2013 Research-status Report
    • Invited

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Published: 2013-05-31   Modified: 2019-07-29  

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