A novel chromatin protein on aging-dependent osteoarthritis

• Project/Area Number: 24592282
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Orthopaedic surgery
• Research Institution: University of Miyazaki (2013-2014); Tokyo Medical University (2012)
• Principal Investigator: TANIGUCHI NOBORU 宮崎大学, 医学部, 助教 (20626866)
• Co-Investigator(Kenkyū-buntansha): 中島 利博 東京医科大学, 医学部, 教授 (90260752)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 変形性関節症 / 加齢 / 軟骨代謝 / 軟骨分化 / SZP / 一過性発現 / 軟骨 / クロマチン蛋白

Outline of Final Research Achievements

It has been reported that a chromatin protein HMGB2 is responsible for aging-dependent osteoarthritis. We succeeded to establish bone marrow-derived mesenchymal stem cells (MSC) from WT and Hmgb2-/- mice and found that a gene X is most down-regulated in Hmgb2-/- MSC. Interestingly, the knockout mice of this gene has been reported as a progeria model, showing that HMGB2-gene X cascade is deeply involved in aging phenomenon. We also found that the mice caused early osteoarthritis. In vitro study, Hmgb2-/- MSC affected not only on chondrogenesis but on osteogenesis and adipogenesis. These findings suggest that new pathways other than Wnt/beta-catenin signal might exist on articular cartilage degeneration.

Research Products

• [Journal Article] Pseudoaneurysm as a complication of shoulder arthroscopy. (2015)
  • Author(s): Ishida Y, Chosa E, Taniguchi N.
  • Journal Title: Knee Surg Sports Traumatol Arthrosc. Volume: 23 Issue: 5 Pages: 1549-51
  • DOI: 10.1007/s00167-014-2956-y
  • Peer Reviewed / Open Access
• [Journal Article] The E3 ligase synoviolin controls body weight and mitochondrial biogenesis through negative regulation of PGC-1β. (2015)
  • Author(s): Fujita H, Yagishita N, Aratani S, Saito-Fujita T, Morota S, Yamano Y, Hansson MJ, Inazu M, Kokuba H, Sudo K, Sato E, Kawahara K, Nakajima F, Hasegawa D, Higuchi I, Sato T, Araya N, Usui C, Nishioka K, Nakatani Y, Maruyama I, Usui M, Hara N, Uchino H, Elmer E, Nishioka K, Nakajima T.
  • Journal Title: EMBO J. Volume: 34 Issue: 8 Pages: 1042-55
  • DOI: 10.15252/embj.201489897
  • Peer Reviewed / Open Access
• [Journal Article] Effects of xenon irradiation of the stellate ganglion region on fibromyalgia (2015)
  • Author(s): Nakajima F, Komoda A, Aratani S, Fujita H, Kawate M, Nakatani K, Akiyama M, Makita K, Nakajima T.
  • Journal Title: Journal of Physical Therapy Science Volume: 27 Issue: 1 Pages: 209-212
  • DOI: 10.1589/jpts.27.209
  • NAID: 130004835113
  • ISSN: 0915-5287, 2187-5626
  • Peer Reviewed / Open Access
• [Journal Article] Synoviolin inhibitor LS-102 reduces endoplasmic reticulum stress-induced collagen secretion in an in vitro model of stress-related interstitial pneumonia. (2015)
  • Author(s): Nakajima F, Aratani S, Fujita H, Yagishita N, Ichinose S, Makita K, Setoguchi Y, Nakajima T.
  • Journal Title: Int J Mol Med. Volume: 35 Issue: 1 Pages: 110-6
  • DOI: 10.3892/ijmm.2014.1984
  • Peer Reviewed / Open Access
• [Journal Article] Mogamulizumab, an anti-CCR4 antibody, targets human T-lymphotropic virus type 1-infected CD8+ and CD4+ T cells to treat associated myelopathy. (2015)
  • Author(s): Yamauchi J, Coler-Reilly A, Sato T, Araya N, Yagishita N, Ando H, Kunitomo Y, Takahashi K, Tanaka Y, Shibagaki Y, Nishioka K, Nakajima T, Hasegawa Y, Utsunomiya A, Kimura K, Yamano Y.
  • Journal Title: J Infect Dis. Volume: 211 Issue: 2 Pages: 238-48
  • DOI: 10.1093/infdis/jiu438
  • Peer Reviewed / Open Access
• [Journal Article] Surface-holding repair: an original arthroscopic rotator cuff repair technique. (2014)
  • Author(s): Taniguchi N, Suenaga N, Oizumi N, Miyoshi N, Araki N, Chosa E.
  • Journal Title: J Shoulder Elbow Surg. Volume: 23 Issue: 5 Pages: 620-7
  • DOI: 10.1016/j.jse.2014.01.007
  • Peer Reviewed / Open Access
• [Journal Article] Suprascapular notch variations: a 3DCT study. (2014)
  • Author(s): Inoue K, Suenaga N, Oizumi N, Sakamoto Y, Sakurai G, Miyoshi N, Taniguchi N, Tanaka Y.
  • Journal Title: J Orthop Sci. Volume: 19 Issue: 6 Pages: 920-4
  • DOI: 10.1007/s00776-014-0636-x
  • Peer Reviewed / Open Access
• [Journal Article] HTLV-1 induces a Th1-like state in CD4+CCR4+ T cells. (2014)
  • Author(s): Araya N, Sato T, Ando H, Tomaru U, Yoshida M, Coler-Reilly A, Yagishita N, Yamauchi J, Hasegawa A, Kannagi M, Hasegawa Y, Takahashi K, Kunitomo Y, Tanaka Y, Nakajima T, Nishioka K, Utsunomiya A, Jacobson S, Yamano Y.
  • Journal Title: J Clin Invest. Volume: 124 Issue: 8 Pages: 3431-42
  • DOI: 10.1172/jci75250
  • Peer Reviewed / Open Access
• [Journal Article] Hrd1 suppresses Nrf2-mediated cellular protection during liver cirrhosis. (2014)
  • Author(s): Wu T, Zhao F, Gao B, Tan C, Yagishita N, Nakajima T, Wong PK, Chapman E, Fang D, Zhang DD.
  • Journal Title: Genes Dev Volume: 28(7) Issue: 7 Pages: 708-722
  • DOI: 10.1101/gad.238246.114
  • Peer Reviewed / Open Access
• [Journal Article] Thymidine phosphorylase regulates the expression of CXCL10 in rheumatoid arthritis fibroblast-like synoviocytes (2014)
  • Author(s): Toyoda Y, Tabata S, Kishi J, Kuramoto T, Mitsuhashi A, Saijo A, Kawano H, Goto H, Aono Y, Hanibuchi M, Horikawa H, Nakajima T, Furukawa T, Sone S, Akiyama S, Nishioka Y
  • Journal Title: Arthritis & Rheumatology Volume: 66(3) Issue: 3 Pages: 560-568
  • DOI: 10.1002/art.38263
  • Peer Reviewed / Open Access
• [Journal Article] Os acromialeを伴った腱板断裂に対する鏡視下腱板修復、Os acromiale切除術 (2014)
  • Author(s): 石田康行, 帖佐悦男, 谷口昇, 田島卓也, 山口奈美, 大田智美, 中村志保子
  • Journal Title: JOSKAS Volume: 39 Pages: 564-568
  • NAID: 120007123089
  • Peer Reviewed / Open Access
• [Journal Article] 当科におけるsuture bridge法による鏡視下腱板修復術－suture bridgeの縫合法の違いによる比較－ (2014)
  • Author(s): 石田康行, 帖佐悦男, 矢野浩明, 谷口昇, 大田智美, 中村志保子, 大塚記史
  • Journal Title: 肩関節 Volume: 38 Pages: 532-536
  • NAID: 130004695627
  • Peer Reviewed / Open Access
• [Journal Article] 関節リウマチに対する人工肩関節置換術後の可動域とADLの関係 (2014)
  • Author(s): 大泉尚美, 末永直樹, 吉岡千佳, 山根慎太郎, 谷口昇
  • Journal Title: 肩関節 Volume: 38 Pages: 650-653
  • NAID: 130004695656
  • Peer Reviewed / Open Access
• [Journal Article] Quadrilateral spaceへの骨棘による腋窩神経障害が原因と考えられた肩甲骨体部骨折後遺残痛の一例 (2014)
  • Author(s): 大塚記史, 石田康行, 矢野浩明, 谷口昇, 大田智美, 中村志保子, 帖佐 悦男
  • Journal Title: 肩関節 Volume: 38 Pages: 496-498
  • NAID: 130004695618
  • Peer Reviewed / Open Access
• [Journal Article] Influence of cartilage extracellular matrix molecules on cell phenotype and neocartilage formation. (2014)
  • Author(s): Grogan SP, Chen X, Sovani S, Taniguchi N, Colwell CW Jr, Lotz MK, D'Lima DD.
  • Journal Title: Tissue Eng Part A. Volume: 20(1-2) Issue: 1-2 Pages: 264-74
  • DOI: 10.1089/ten.tea.2012.0618
  • Peer Reviewed
• [Journal Article] 70歳未満の修復不能な広範囲腱板断裂に対する小径人工骨頭置換術を併用した腱板再建術 (2013)
  • Author(s): 三好 直樹、伊藤 浩、末永 直樹、大泉 尚美、谷口 昇
  • Journal Title: 肩関節 Volume: 37(3) Pages: 1221-1225
  • NAID: 130003393667
  • Peer Reviewed
• [Journal Article] 腱板断裂に対する鏡視下 Surface-holding 法の治療成績と cuff integrity (2013)
  • Author(s): 大泉 尚美、末永 直樹、吉岡 千佳、山根 慎太郎、谷口 昇
  • Journal Title: 肩関節 Volume: 37(3) Pages: 1085-1088
  • NAID: 130003393668
  • Peer Reviewed
• [Journal Article] Mechanical injury suppresses autophagy regulators and pharmacologic activation of autophagy results in chondroprotection. (2012)
  • Author(s): Carames B, Taniguchi N, Seino D, Blanco FJ, D'Lima D, Lotz M.
  • Journal Title: Arthritis Rheum. Volume: 64(4) Issue: 4 Pages: 1182-92
  • DOI: 10.1002/art.33444
  • Peer Reviewed
• [Journal Article] Autophagy activation by rapamycin reduces severity of experimental osteoarthritis. (2012)
  • Author(s): Carames B, Hasegawa A, Taniguchi N, Miyaki S, Blanco FJ, Lotz M.
  • Journal Title: Ann Rheum Dis. Volume: 71(4) Issue: 4 Pages: 575-81
  • DOI: 10.1136/annrheumdis-2011-200557
  • Peer Reviewed
• [Journal Article] Association of cartilage-specific deletion of peroxisome proliferator-activated receptor γ with abnormal endochondral ossification and impaired cartilage growth and development in a murine model. (2012)
  • Author(s): Monemdjou R, Vasheghani F, Fahmi H, Perez G, Blati M, Taniguchi N, Lotz M, St-Arnaud R, Pelletier JP, Martel-Pelletier J, Beier F, Kapoor M.
  • Journal Title: Arthritis Rheum. Volume: 64(5) Issue: 5 Pages: 1551-61
  • DOI: 10.1002/art.33490
  • Peer Reviewed
• [Journal Article] 術前挙上不全な Rotator Cuff Deficient Arthropathy に対する人工骨頭置換術と腱板再建術 (2012)
  • Author(s): 谷口昇、末永直樹、山口浩
  • Journal Title: 肩関節 Volume: 36(3) Pages: 829-32
  • NAID: 130002103543
  • Peer Reviewed
• [Presentation] 重度のcuff tear arthropathyに対して広背筋・大胸筋・肩甲下筋部分移行を併用した小径骨頭による人工骨頭置換術を行った1例 (2015)
  • Author(s): 谷口昇、末永直樹、大泉尚美、三好直樹、石田康行、帖佐悦男
  • Organizer: 第45回日本人工関節学会
  • Place of Presentation: 福岡国際会議場
  • Year and Date: 2015-02-27 – 2015-02-28
• [Presentation] Outcome of anatomic reconstructive surgery for the elderly with irreparable massive rotator cuff tear. (2014)
  • Author(s): Taniguchi N, Suenaga N, Miyoshi N, Oizumi N, Chosa E.
  • Organizer: XXVI SICOT Triennial World Congress
  • Place of Presentation: Rio de Janeiro, Brazil
  • Year and Date: 2014-11-19 – 2014-11-22
• [Presentation] Surface-holding repair: an original arthroscopic rotator cuff repair technique. (2014)
  • Author(s): Taniguchi N, Suenaga N, Oizumi N, Miyoshi N, Chosa E.
  • Organizer: XXVI SICOT Triennial World Congress
  • Place of Presentation: Rio de Janeiro, Brazil
  • Year and Date: 2014-11-19 – 2014-11-22
• [Presentation] 腱板断裂後関節症の関節内遊離骨片が腕神経叢麻痺を呈した一例 (2014)
  • Author(s): 谷口昇、石田康行、矢野浩明、中村志保子、宮崎茂明、末永直樹、帖佐悦男
  • Organizer: 第41回日本肩関節学会
  • Place of Presentation: 佐賀市文化会館
  • Year and Date: 2014-10-25 – 2014-10-26
• [Presentation] Bone marrow stimulation during arthroscopic rotator cuff repair advances cuff repair integrity. (2014)
  • Author(s): Taniguchi N, Suenaga N, Oizumi N, Miyoshi N, Chosa E.
  • Organizer: 25th SECEC-ESSSE Congress
  • Place of Presentation: Istanbul, Turkey
  • Year and Date: 2014-09-17 – 2014-09-20
• [Presentation] 鏡視下surface-holding法施行後の再断裂症例に対する経時的変化の検討 (2014)
  • Author(s): 谷口昇、末永直樹、吉岡千佳、大泉尚美、石田康行、帖佐悦男
  • Organizer: 第6回 日本関節鏡・膝・スポーツ整形外科学会
  • Place of Presentation: 広島国際会議場
  • Year and Date: 2014-07-26 – 2014-07-27
• [Presentation] 生物学的治癒促進を目的としたARCRと腱板修復形態の検討 (2014)
  • Author(s): 谷口昇、末永直樹、吉岡千佳、大泉尚美、石田康行、帖佐悦男
  • Organizer: 第87回日本整形外科学会学術総会
  • Place of Presentation: 神戸コンベンションセンター
  • Year and Date: 2014-05-22 – 2014-05-25
• [Presentation] 後期高齢者の修復不能な腱板広範囲断裂に対する小径骨頭を用いた人工骨頭置換術と腱板再建術 (2014)
  • Author(s): 谷口昇、末永 直樹、三好直樹、大泉直樹、帖佐悦男
  • Organizer: 第44回日本人工関節学会
  • Place of Presentation: 沖縄コンベンションセンター
• [Presentation] 加齢依存性変形性関節症とクロマチン蛋白HMGB2の役割 (2013)
  • Author(s): 谷口昇、Martin Lotz
  • Organizer: 第28回日本整形外科基礎学会
  • Place of Presentation: 千葉市
• [Presentation] 超高齢者の修復不能な腱板広範囲断裂に対する解剖学的再建術 (2013)
  • Author(s): 谷口昇、末永直樹、三好直樹、帖佐悦男
  • Organizer: 第40回日本肩関節学会
  • Place of Presentation: 京都市
• [Presentation] 生物学的治癒促進を目的としたARCRと腱板修復形態の検討 (2013)
  • Author(s): 谷口昇、末永直樹、吉岡千佳、大泉尚美、帖佐悦男
  • Organizer: 第40回日本肩関節学会
  • Place of Presentation: 京都市
• [Presentation] 高齢者と若年者の広範囲腱板断裂と鏡視下Surface-holding法 (2013)
  • Author(s): 谷口昇、末永直樹、大泉尚美、三好直樹、帖佐悦男
  • Organizer: 第40回日本肩関節学会
  • Place of Presentation: 京都市
• [Presentation] 鏡視下surface holding法施行後の再断裂症例の経時的変化の検討 (2013)
  • Author(s): 谷口昇、末永直樹、吉岡千佳、大泉尚美、帖佐悦男
  • Organizer: 第40回日本肩関節学会
  • Place of Presentation: 京都市
• [Presentation] 生物学的治癒促進を目的としたARCRは再断裂率を減少させる (2013)
  • Author(s): 谷口昇、末永直樹、大泉尚美、三好直樹、細川吉博
  • Organizer: 第39回日本整形外科学会
  • Place of Presentation: 広島市
• [Presentation] Anatomical reconstruction using small size humeral head replacement for rotator cuff deficient arthropathy with pseudoparalysis. (2013)
  • Author(s): Taniguchi N, Suenaga N, Yamaguchi H, Hosokawa Y.
  • Organizer: 12th International Congress of Shoulder and Elbow Surgery
  • Place of Presentation: Nagoya, Japan
• [Presentation] Arthroscopic repair by modified transosseous-equivalent procedure for the elderly with rotator cuff tear. (2013)
  • Author(s): Taniguchi N, Suenaga N, Oizumi N, Hosokawa Y.
  • Organizer: 12th International Congress of Shoulder and Elbow Surgery
  • Place of Presentation: Nagoya, Japan
• [Presentation] Arthroscopic rotator cuff repair for the purpose of biological regeneration advances rotator cuff retear. (2013)
  • Author(s): Taniguchi N, Suenaga N, Oizumi N, Miyoshi N, Funakoshi T.
  • Organizer: 12th International Congress of Shoulder and Elbow Surgery
  • Place of Presentation: Nagoya, Japan
• [Presentation] 幹細胞に富む関節軟骨表層に特異的に発現するクロマチン蛋白HMGB2の役割 (2013)
  • Author(s): 谷口昇
  • Organizer: 東京医科大学医学総合研究所シンポジウム「運動機能再生の最近の進歩」
  • Place of Presentation: 東京医大
  • Invited
• [Presentation] クロマチン蛋白HMGB2はWntシグナル経路を介して関節軟骨表層の恒常性維持に関与する (2012)
  • Author(s): 谷口昇
  • Organizer: 第56回日本リウマチ学会総会・学術集会
  • Place of Presentation: グランドプリンスホテル新高輪
• [Presentation] 高齢者の腱板断裂に対する鏡視下Surface-holding repair法の術後成績 (2012)
  • Author(s): 谷口昇、末永直樹、荒木典也、大泉尚美、吉岡千佳、細川吉博
  • Organizer: 第4回日本関節鏡・膝・スポーツ整形外科学会
  • Place of Presentation: 沖縄コンベションセンター
• [Presentation] 生物学的治癒促進を目的としたARCRは再断裂率を減少させる (2012)
  • Author(s): 谷口昇、末永直樹、大泉尚美、三好直樹、船越忠直
  • Organizer: 第39回日本肩関節学会
  • Place of Presentation: 京王プラザホテル
• [Presentation] 高齢者の腱板断裂に対する鏡視下surface-holding法の術後成績 (2012)
  • Author(s): 谷口昇、末永直樹、大泉尚美、荒木典也、細川吉博
  • Organizer: 第39回日本肩関節学会
  • Place of Presentation: 京王プラザホテル
• [Book] 臨床整形外科 (2014)
  • Author(s): 谷口昇
  • Total Pages: 1
  • Publisher: 医学書院
• [Book] Monthly Book Orthopaedics (2013)
  • Author(s): 谷口昇、末永直樹
  • Total Pages: 11
  • Publisher: 全日本病院出版会