A novel chromatin protein on aging-dependent osteoarthritis
Project/Area Number |
24592282
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Orthopaedic surgery
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Research Institution | University of Miyazaki (2013-2014) Tokyo Medical University (2012) |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
中島 利博 東京医科大学, 医学部, 教授 (90260752)
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Project Period (FY) |
2012-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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Keywords | 変形性関節症 / 加齢 / 軟骨代謝 / 軟骨分化 / SZP / 一過性発現 / 軟骨 / クロマチン蛋白 |
Outline of Final Research Achievements |
It has been reported that a chromatin protein HMGB2 is responsible for aging-dependent osteoarthritis. We succeeded to establish bone marrow-derived mesenchymal stem cells (MSC) from WT and Hmgb2-/- mice and found that a gene X is most down-regulated in Hmgb2-/- MSC. Interestingly, the knockout mice of this gene has been reported as a progeria model, showing that HMGB2-gene X cascade is deeply involved in aging phenomenon. We also found that the mice caused early osteoarthritis. In vitro study, Hmgb2-/- MSC affected not only on chondrogenesis but on osteogenesis and adipogenesis. These findings suggest that new pathways other than Wnt/beta-catenin signal might exist on articular cartilage degeneration.
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Report
(4 results)
Research Products
(45 results)
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[Journal Article] The E3 ligase synoviolin controls body weight and mitochondrial biogenesis through negative regulation of PGC-1β.2015
Author(s)
Fujita H, Yagishita N, Aratani S, Saito-Fujita T, Morota S, Yamano Y, Hansson MJ, Inazu M, Kokuba H, Sudo K, Sato E, Kawahara K, Nakajima F, Hasegawa D, Higuchi I, Sato T, Araya N, Usui C, Nishioka K, Nakatani Y, Maruyama I, Usui M, Hara N, Uchino H, Elmer E, Nishioka K, Nakajima T.
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Journal Title
EMBO J.
Volume: 34
Issue: 8
Pages: 1042-55
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Mogamulizumab, an anti-CCR4 antibody, targets human T-lymphotropic virus type 1-infected CD8+ and CD4+ T cells to treat associated myelopathy.2015
Author(s)
Yamauchi J, Coler-Reilly A, Sato T, Araya N, Yagishita N, Ando H, Kunitomo Y, Takahashi K, Tanaka Y, Shibagaki Y, Nishioka K, Nakajima T, Hasegawa Y, Utsunomiya A, Kimura K, Yamano Y.
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Journal Title
J Infect Dis.
Volume: 211
Issue: 2
Pages: 238-48
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] HTLV-1 induces a Th1-like state in CD4+CCR4+ T cells.2014
Author(s)
Araya N, Sato T, Ando H, Tomaru U, Yoshida M, Coler-Reilly A, Yagishita N, Yamauchi J, Hasegawa A, Kannagi M, Hasegawa Y, Takahashi K, Kunitomo Y, Tanaka Y, Nakajima T, Nishioka K, Utsunomiya A, Jacobson S, Yamano Y.
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Journal Title
J Clin Invest.
Volume: 124
Issue: 8
Pages: 3431-42
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Thymidine phosphorylase regulates the expression of CXCL10 in rheumatoid arthritis fibroblast-like synoviocytes2014
Author(s)
Toyoda Y, Tabata S, Kishi J, Kuramoto T, Mitsuhashi A, Saijo A, Kawano H, Goto H, Aono Y, Hanibuchi M, Horikawa H, Nakajima T, Furukawa T, Sone S, Akiyama S, Nishioka Y
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Journal Title
Arthritis & Rheumatology
Volume: 66(3)
Issue: 3
Pages: 560-568
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Association of cartilage-specific deletion of peroxisome proliferator-activated receptor γ with abnormal endochondral ossification and impaired cartilage growth and development in a murine model.2012
Author(s)
Monemdjou R, Vasheghani F, Fahmi H, Perez G, Blati M, Taniguchi N, Lotz M, St-Arnaud R, Pelletier JP, Martel-Pelletier J, Beier F, Kapoor M.
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Journal Title
Arthritis Rheum.
Volume: 64(5)
Issue: 5
Pages: 1551-61
DOI
Related Report
Peer Reviewed
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