Analysis of the mechanism for joint destruction via SDF-1 in rheumatoid arthritis
| Project/Area Number |
24592284
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Tokyo Women's Medical University |
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Principal Investigator |
KANBE Katsuaki 東京女子医科大学, 医学部, 准教授 (70366326)
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| Co-Investigator(Renkei-kenkyūsha) |
INOUE Yasuo 東京女子医科大学, 医学部, 助教 (00408519)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | 関節リウマチ / 滑膜 / 組織 / 免疫染色 / SDF-1 / CXCR4 / 関節破壊 / 骨破壊 / 生物学的製剤 / 組織学 / サイトカイン / TNF-α / IL-6 / 病態 / 骨関節破壊 / TNF-alpha |
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| Outline of Final Research Achievements |
Using an immunohistological analysis of synovium from rheumatoid arthritis (RA), we determined whether disease activity and joint destruction were correlated with the levels of SDF-1 and CXCR4 by IH scores [1]. SDF-1 was strongly correlated with the DAS28 CRP and serum IL-6. CXCR4 was correlated with synovial CD4 and the Assessment of RA by Scoring of Large-Joint Destruction and Healing in Radiographic Imaging (ARASHI) score. CD4 was correlated with the van der Heijde-modified Sharp (vdH-S) score. Therefore synovial SDF-1 was correlated with disease activity, and its receptor CXCR4 was related to large joint destruction in RA. In this study, T lymphocyte expressed CD4 via SDF-1/ CXCR4 axis is possible to be important for the mechanism of joint destruction in RA.
1.Kanbe K, et al. Modern Rheumatology 24:910-914,2014.
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Report
(4 results)
Research Products
(21 results)
