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Genome-wide association study of drug response to methotrexate n rheumatoid arthritis patients

Research Project

Project/Area Number 24592285
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Orthopaedic surgery
Research InstitutionTokyo Women's Medical University

Principal Investigator

IKARI Katsunori  東京女子医科大学, 医学部, 准教授 (80343557)

Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords薬剤反応性遺伝子 / メトトレキセート / 関節リウマチ / メトトレキサート / 薬剤反応性 / 遺伝子
Outline of Final Research Achievements

First screening was done with the GWAS data from the other project (Human Omni Express). The study included 678 patients who had a history of MTX intake. Logistic regression analysis was used for statistical analysis. We identified three SNPs located near CCBE1, RCSD1 and EFR3A that were associated with drug response of methotrexate using genome-wide association study.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (21 results)

All 2015 2014 2013 2012 Other

All Journal Article (20 results) (of which Peer Reviewed: 20 results,  Open Access: 3 results) Remarks (1 results)

  • [Journal Article] Construct validity, reliability, response rate, and association with disease activity of the quick disabilities of the arm, shoulder and hand questionnaire in the assessment of rheumatoid arthritis.2015

    • Author(s)
      Ochi K, Iwamoto T, Saito A, Ikari K, Toyama Y, Taniguchi A, Yamanaka H, Momohara S.
    • Journal Title

      Mod Rheumatol.

      Volume: X

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] An association between the 74th amino acid position of HLA-DRB1 and ACPA levels of Japanese ACPA-positive RA.2015

    • Author(s)
      Terao C, Suzuki A, Ikari K, Kochi Y, Ohmura K, Katayama M, Nakabo S, Yamamoto N, Suzuki T, Iwamoto T, Yurugi K, Miura Y, Maekawa T, Takasugi K, Kubo M, Saji H,Taniguchi A, Momohara S, Yamamoto K, Yamanaka H, Mimori T, Matsuda F.
    • Journal Title

      Arthritis Rheumatol.

      Volume: X Issue: 8 Pages: 2038-2045

    • DOI

      10.1002/art.39133

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A main contribution of DRB1*04:05 among shared epitope and involvement of 57th DRB1 amino acid in association with joint destruction in ACPA(+) RA.2015

    • Author(s)
      Terao C, Yano K, Ikari K, Furu M, Yamakawa N, Yoshida S, Hashimoto M, Ito H,Fujii T, Ohmura K, Yurugi K, Miura Y, Maekawa T, Taniguchi A, Momohara S,Yamanaka H, Mimori T, Matsuda F.
    • Journal Title

      Arthritis Rheumatol.

      Volume: X Issue: 7 Pages: 1744-1750

    • DOI

      10.1002/art.39105

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Risk factors for established vertebral fractures in Japanese patients with rheumatoid arthritis: Results from a large prospective observational cohort study.2015

    • Author(s)
      Ishida O, Furuya T, Inoue E, Ochi K, Ikari K, Taniguchi A, Yamanaka H, Momohara S.
    • Journal Title

      Mod Rheumatol.

      Volume: X

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Validity and responsiveness of a self-administered foot evaluation questionnaire in rheumatoid arthritis.2015

    • Author(s)
      Yano K, Ikari K, Ochi K, Ishida O, Sakuma Y, Yoshida S, Koyama T, Koenuma N, Momohara S.
    • Journal Title

      Mod Rheumatol.

      Volume: X

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ten-year incidences of self-reported non-vertebral fractures in Japanese patients with rheumatoid arthritis: discrepancy between disease activity control and the incidence of non-vertebral fracture.2015

    • Author(s)
      Ochi K, Inoue E, Furuya T, Ikari K, Toyama Y, Taniguchi A, Yamanaka H, Momohara S.
    • Journal Title

      Osteoporos Int.

      Volume: 26 Issue: 3 Pages: 961-8

    • DOI

      10.1007/s00198-014-2911-2

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Response to ‘Peptidyl arginine deiminase type IV (PADI4) haplotypes interact with shared epitope regardless of anti-cyclic citrullinated peptide antibody or erosive joint status in rheumatoid arthritis: a case control study’2014

    • Author(s)
      Ikari K, Yano K, Yoshida S, Taniguchi A, Yamanaka H, Momohara S.
    • Journal Title

      Arthritis Res Ther.

      Volume: 16 Issue: 4 Pages: 422-422

    • DOI

      10.1186/s13075-014-0422-3

    • NAID

      120005521016

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] An osteoprotegerin gene polymorphism is associated with an increased risk of hip fracture in Japanese patients with rheumatoid arthritis: results from the IORRA Observational Cohort Study.2014

    • Author(s)
      Yoshida S, Ikari K, Furuya T, Toyama Y, Taniguchi A, Yamanaka H, Momohara S.
    • Journal Title

      PLoS One

      Volume: 9 Issue: 8 Pages: e104587-e104587

    • DOI

      10.1371/journal.pone.0104587

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Attrition rupture of ulnar nerve in an elbow of a patient with rheumatoid arthritis.2014

    • Author(s)
      Ochi K, Ikari K, Momohara S.
    • Journal Title

      J Rheumatol.

      Volume: 41 Issue: 10 Pages: 2085-2085

    • DOI

      10.3899/jrheum.140555

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ffects of smoking and shared epitope on the production of anti-citrullinated peptide antibody in a Japanese adultpopulation.2014

    • Author(s)
      Terao C, Ohmura K, Ikari K, Kawaguchi T, Takahashi M, Setoh K, Nakayama T,Kosugi S, Sekine A, Tabara Y, Taniguchi A, Momohara S, Yamanaka H, Yamada R,Matsuda F, Mimori T; Nagahama Study Group
    • Journal Title

      Arthritis Care Res (Hoboken)

      Volume: 66 Issue: 12 Pages: 1818-27

    • DOI

      10.1002/acr.22385

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Recent trends in orthopedic surgery aiming to improve quality of life for those with rheumatoid arthritis: data from a large observational cohort.2014

    • Author(s)
      Momohara S, Inoue E, Ikari K, Ochi K, Ishida O, Yano K, Sakuma Y, Yoshida S, Koyama T, Koenuma N, Taniguchi A, Yamanaka H.
    • Journal Title

      J Rheumatol.

      Volume: 41 Issue: 5 Pages: 862-6

    • DOI

      10.3899/jrheum.131018

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genetics of rheumatoid arthritis contributes to biology and drug discovery.2014

    • Author(s)
      Okada Y, Wu D, Trynka G, Raj T, Terao C, Ikari K, Kochi Y, Ohmura K, Suzuki A, Yoshida S, Graham RR, Manoharan A, Ortmann W, Bhangale T, Denny JC, (省略), GARNET consortium, (以下省略).
    • Journal Title

      Nature

      Volume: 506 Issue: 7488 Pages: 376-381

    • DOI

      10.1038/nature12873

    • Related Report
      2013 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Lack of association between IL-15 genetic variants and progression of joint destruction in Japanese patients with rheumatoid arthritis2014

    • Author(s)
      Yoshida, S. Ikari, K. Yano, K. Toyama, Y. Taniguchi, A. Yamanaka, H. Momohara, S.
    • Journal Title

      Ann Rheum Dis

      Volume: online Issue: 4 Pages: 784-785

    • DOI

      10.1136/annrheumdis-2013-203921

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] PLD4 as a novel susceptibility gene for systemic sclerosis in a Japanese population2013

    • Author(s)
      Terao C, Ohmura K, Kawaguchi Y, Nishimoto T, Kawasaki A, Takehara K, Furukawa H, Kochi Y, Ota Y, Ikari K, Sato S, Tohma S, Yamada R, Yamamoto K, Kubo M, Yamanaka H, Kuwana M, Tsuchiya N, Matsuda F, Mimori T
    • Journal Title

      Arthritis Rheum

      Volume: 65 Issue: 2 Pages: 472-480

    • DOI

      10.1002/art.37777

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] A genome-wide sib-pair linkage analysis of Ossification of the posterior longitudinal ligament of the spine2013

    • Author(s)
      Tatsuki Karasugi
    • Journal Title

      J Bone Miner Metab.

      Volume: 31 Issue: 2 Pages: 136

    • DOI

      10.1007/s00774-012-0404-y

    • NAID

      10031168848

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Non-synonymous variant (Gly307Ser) in CD226 is associated with susce ptibility in Japanese rheumatoid arthritis patients2012

    • Author(s)
      Suzuki T, Ikari K, et al
    • Journal Title

      Modern rheumatology

      Volume: (e-pub) Issue: 1 Pages: 200-202

    • DOI

      10.1007/s10165-012-0609-x

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] ACPA-negative RA consists of two genetically distinct subsets based on RF positivity in Japanese.2012

    • Author(s)
      Terao C, Mimori T, et al (21人中21人目)
    • Journal Title

      PLoS One

      Volume: 7 Issue: 7 Pages: e40067-e40067

    • DOI

      10.1371/journal.pone.0040067

    • NAID

      120004754351

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Quantitative effect of HLA-DRB1 alleles to ACPA levels in Japanese rheumatoid arthritis : no strong genetic impact of shared epitope to ACPA levels after stratification of HLA-DRB1^*09:012012

    • Author(s)
      Terao C, Ikari K, et al
    • Journal Title

      Annals of the rheumatic diseases

      Volume: (e-pub) Issue: 6 Pages: 1095-1097

    • DOI

      10.1136/annrheumdis-2011-200907

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population2012

    • Author(s)
      Okada Y, Terao C, Ikari K, Kochi Y, Ohmura K, Suzuki A, Kawaguchi T, Stahl EA, Kurreeman FA, Nishida N, Ohmiya H, Myouzen K, Takahashi M, Sawada T, Nishioka Y, Yukioka M, Matsubara T, Wakitani S, Teshima R, Tohma S, Takasugi K, Shimada K, Murasawa A, Honjo S, Matsuo K, Tanaka H, Tajima K, Suzuki T, Iwamoto T, Kawamura Y, Tanii H, Okazaki Y, Sasaki T, Gregersen PK, Padyukov L, Worthington J, Siminovitch KA, Lathrop M, Taniguchi A, Takahashi A, Tokunaga K, Kubo M, Nakamura Y, Kamatani N, Mimori T, Plenge RM, Yamanaka H, Momohara S, Yamada R, Matsuda F, Yamamoto K.
    • Journal Title

      Nat Genet.

      Volume: (in press) Issue: 5 Pages: 511-6

    • DOI

      10.1038/ng.2231

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Functional variants in NFKBIE and RTKN2 involved in activation of the NF-κB pathway are associated with rheumatoid arthritis in Japanese.2012

    • Author(s)
      Myouzen K, Kochi Y, Okada Y, Terao C, Suzuki A et al.
    • Journal Title

      PLoS Genet

      Volume: 8 Issue: 9 Pages: e1002949-e1002949

    • DOI

      10.1371/journal.pgen.1002949

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Remarks] 東京女子医科大学膠原病リウマチ痛風センター

    • URL

      http://www.twmu.ac.jp/IOR/

    • Related Report
      2014 Annual Research Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

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