Mechanisms of postoperative cognitive dysfunction after inhalation of volatile anesthetics
| Project/Area Number |
24592292
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Anesthesiology/Resuscitation studies
|
|---|
| Research Institution | Akita University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
MASAKI Youko 秋田大学, 医学(系)研究科(研究院), 助教 (30125744)
KAWAMURA KOICHI 秋田大学, 医学(系)研究科(研究院), 准教授 (00091801)
ABE KYOKO 秋田大学, 医学部, 助教 (30311575)
西川 俊昭 秋田大学, 医学(系)研究科(研究院), 教授 (50156048)
|
|---|
| Project Period (FY) |
2012-04-01 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
|
|---|
| Keywords | 術後認知機能 / 吸入麻酔薬 / セボフルラン / 微細構造 / 血管新生 / 術後認知機能障害 / 高齢者 / 手術 / 吸入麻酔 / 脳 / 国際情報交換 |
|---|
| Outline of Final Research Achievements |
Study I: Rats were divided into young and aged group. Then, each group was subdivided into control, general anesthesia without surgery, and general anesthesia with surgery group. All rats except those in the control group were anesthetized for 1 h with 2% sevofurane and 33% oxygen. In the control group, both the young and aged controls acquired spatial memory in Morris Water Maze. Both anesthesia with and without surgery impaired spatial learning in aged rats but not in young rats.
Study II: We divided rats into just after sevoflurane, 7 days after sevoflurane and the control group. Rats were anesthetized with 2% sevoflurane, 33% oxygen for 2 h in the group sevoflurane. The brain was observed in a transmission electron microscope. Some degeneration cells were found in the sevoflurane groups. We found angiogenesis 7 days after sevoflurane anesthesia. Angiogenesis is likely to be induced in the restoration process of the degenerated brain cells caused by sevoflurane anesthesia.
|
Report
(5 results)
Research Products
(9 results)
