Prognisis after anaogesic treatment for cancer pain

• Project/Area Number: 24592296
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Anesthesiology/Resuscitation studies
• Research Institution: Shimane University
• Principal Investigator: SAITO Yoji 島根大学, 医学部, 教授 (50162243)
• Co-Investigator(Kenkyū-buntansha): HASHIMOTO Tatsuya 島根大学, 医学部, 講師 (00372681) ; KIRIHARA Yumiko 島根大学, 医学部, 助手 (90234400) ; NAKATANI Toshihiko 島根大学, 医学部, 教授 (90237305)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: がん性疼痛 / オピオイド / モルヒネ / オープンフィールド / 明暗テスト / 社交性テスト / QOL / ＱＯＬ / オープンフィールドテスト

Outline of Final Research Achievements

Though response to mechanical, thermal, or chemical stimulation has often been used as pain behavior in animal experimental model, it is also important to measure the behaviors associated with spontaneous, ongoing pain, which is a more complex percept
that has a significant emotional contribution and is more reflective of clinical pain conditions. In mice bone cancer pain model, we observed significant change in, not only evoked pain behavior, but also spontaneous behavior, and systemic opioid shows its analgesic effect dose dependently in the both experiments. Interestingly, bone cancer pain in mice also affects the spontaneous activity and emotional pain behavior related with anxiety and social interaction. Furthermore, systemic morphine could recover their spontaneous activity, but not emotion. Effect of morphine varies according to the different kinds of behavior in mice. Our results are helpful for understanding the relationship between analgesic and quality of life in human.

Research Products

• [Presentation] マウス骨癌性疼痛モデルにおける自発痛および疼痛関連行動の検討 (2014)
  • Author(s): 二階哲朗, 勝部由貴子, 太田淳一, 齊藤洋司
  • Organizer: 日本麻酔科学会第61回学術集会
  • Place of Presentation: パシフィコ横浜（神奈川県・横浜市）
  • Year and Date: 2014-05-15 – 2014-05-17
• [Presentation] Characteristics of pain-related behavior in chronic inflammatory model and cancer pain model in mice. (2013)
  • Author(s): Katsube Y, Nikai T, Ota J, Saito Y
  • Organizer: American society of Anesthesiologists, Annual meeting
  • Place of Presentation: San Francisco （United States of America）
• [Presentation] STUDY OF BONE CANCER PAIN MODEL IN MICE: COMPARISON BY STRAIN AND SEX (2012)
  • Author(s): 1. Yumiko Kirihara, 2. Mayumi Takechi, 3. Kaoru Kurosaki, 4. Yuta Kobayashi and 5. Yoji Saito
  • Organizer: 世界疼痛学会
  • Place of Presentation: ミラノ（イタリア）