|Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
|Outline of Final Research Achievements
H2S was evaluated for therapeutic potential on stress-induced insulin resistance and vascular endothelial damage. Vascular endothelial damage is a major cause of organ failure in stress-induced insulin resistance. Whereas hydrogen sulfide often expressed in vascular endothelium, have various physiological activities, and attracted attention to arteriosclerosis, diabetes, and sepsis.
Burn rat was used as a model for critical disease. Burn injury was prepared to male SD rats, and L-cysteine a substrate of hydrogen sulfide production was administered by oral. The descending aorta after three days from the injury was sampled and subjected to the experiment. Hydrogen sulfide improved insulin resistance, further to suppress oxidative stress, it tended to improve vascular relaxation response. H2S can be expected as a potential therapeutic agent.