Development of Novel Therapeutic Strategy for Spinal Cord Injury by New Vitamin E derivative, ETS-GS
| Project/Area Number |
24592303
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Anesthesiology/Resuscitation studies
|
|---|
| Research Institution | Oita University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
Hagiwara Satoshi 大分大学, 医学部, 講師 (50527661)
Oyama Yoshimasa 大分大学, 医学部, 助教 (40468012)
|
|---|
| Project Period (FY) |
2012-04-01 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
|
|---|
| Keywords | ビタミンE / 脊髄損傷 / ETS-GS / spnal cord injury / vitamin E / ビタミンＥ |
|---|
| Outline of Final Research Achievements |
To investigate whether ETS-GS, a novel antioxidant that is a conjugate compound of glutathione, taurine, and vitamin E can treat disabilities caused by spinal cord injury and to determine the mechanism using rat models. After introducing a contusion injury at Th11 level into rats, they were separated into 3-day ETS-GS and saline dose groups. After day 3, the spinal cords were extracted for biochemical and histological analysis. A significant improvement in the Basso, Beattie, and Bresnahan (BBB) score was confirmed following ETS-GS dose. In addition, an ETS-GS-mediated reduction in myeloperoxidase (MPO), malondialdehyde (MDA), caspase-3 was observed along with a decrease in apoptotic cells as assessed by TUNEL staining. In conclusion, we observed that ETS-GS can treat disabilities caused by spinal cord injury, through suppressing inflammation, lipid peroxidation and inhibiting nerve cell apoptosis.
|
Report
(5 results)
Research Products
(3 results)
