| Project/Area Number |
24592304
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Oita University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KITANO Takaaki 大分大学, 医学部, 教授 (20211196)
YOKOI Isao 大分大学, 医学部, 教授 (80150366)
KOGA Hironori 大分大学, 医学部, 助教 (50468013)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | アセチル-L-カルニチン / 脳保護 / 核磁気共鳴法 / 電子スピン共鳴法 / フリーラジカル / 抗酸化能 / ラジカル消去能 / 高エネルギーリン酸 / 脳保護作用 / カルニチン / 虚血再潅流傷害 / スピントラップ法 / 虚血再灌流傷害 / スピントラップ / 脳虚血 / クレアチンリン酸 / ATP / 病態生理学 |
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| Outline of Final Research Achievements |
Neuroprotective effect of acetyl-L-carnitine (ALCAR) on rat brain slices after ischemia/reperfusion injury was investigated by 31P-NMR and ESR spectroscopy. Energetically, ALCAR was neuroprotective in normal brain slices. ALCAR demonstrated antioxidative activity against some free radical species, but it also showed rather prooxidative activity against others at higher concentrations. Those findings suggest that ALCAR acts as energy substrate and antioxidant in protecting brain tissue from ischemia/reperfusion injury, but may act as prooxidant at higher concentration.
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