| Project/Area Number |
24592313
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
Hayashi Kazuko 京都府立医科大学, 医学(系)研究科(研究院), 客員講師 (40285276)
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| Research Collaborator |
SAWA Teiji 京都府立医科大学, 医学研究科, 教授 (10206013)
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | α波 / 加齢 / 睡眠 / 意識 / 麻酔 / コヒーレンス / 後頭 / 覚醒 / 脳神経ネットワーク / 脳波 / 脳神経科学 / 麻酔意識制御 / 脳内ネットワーク / alpha wave / binding / 統合 / 複雑系 / 後頭脳波 / 状態空間 / 認知症 / 譫妄 / パワースペクトル / 意識レベル |
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| Outline of Final Research Achievements |
A prominent alpha rhythm accompanying high bicoherence growth is often seen in occipital awake EEGs in younger persons. With the induction of anesthesia, the occipital alpha bicoherence peak disappears and a frontal alpha bicoherence peak appears. The occipital neural network is spatially differently modulated from the frontal EEG in the regulation of consciousness and anesthesia.
On the other hand, in the elderly, δ-θ bicoherence increased under deeper anaesthesia, similarly to healthy adults, but alpha bicoherence growth was small irrespective of anaesthesia level. Frontal α bicoherence growth in the elderly EEG did not change with the depth of sevoflurane anaesthesia, contrasting with the healthy adult showing anaesthesia-dependent change in alpha activity, indicating that the neural network creating alpha waves may be modulated by aging.
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