The protective effects of anesthetics on ischemia reperfusion injury in kidney and liver

• Project/Area Number: 24592316
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Anesthesiology/Resuscitation studies
• Research Institution: Jikei University School of Medicine
• Principal Investigator: Mio Yasushi 東京慈恵会医科大学, 医学部, 准教授 (00266686)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000); Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 虚血再灌流障害 / 麻酔薬 / ミトコンドリア / 臓器保護 / 肝臓 / 腎臓

Outline of Final Research Achievements

The volatile anesthetics protected mitochondrial respiratory function against ischemia-reperfusion injury in rat liver and kidney. Further, the anesthetics inhibited complex I of the electron transport chain in mitochondria, which may in part underlie the mechanism for protective effects in both organs. These results may suggest the advantage of use of volatile anesthetics on kidney and liver surgery. The protective effects of nicorandil and anesthetics against contrast-induced renal mitochondrial injury were not observed.