Mechanism elucidation of the general anesthesia from a view point of the changes in the internal gene expression
| Project/Area Number |
24592318
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Nippon Medical School |
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Principal Investigator |
SAKAMOTO Atsuhiro 日本医科大学, 医学(系)研究科(研究院), 教授 (30196084)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 全身麻酔 / 遺伝子発現 / microRNA / TLDA / 吸入麻酔薬 / 静脈麻酔薬 / マイクロRNA / 神経障害性疼痛 / マイクロＲＮＡ / 全身麻酔薬 / miRNA |
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| Outline of Final Research Achievements |
The effects of general anesthetics on the changes of internal gene expression, especially microRNA (miRNA) expression were evaluated mainly by TaqMan Low-density Array (TLDA) analysis. The main results are as follows. (1) The general anesthetics affect miRNA expression in the vital organs (lung, liver, blood, brain and supine). (2) The different anesthetics show the different influence on miRNA expression. (3) The pathologic changes of the central nervous system influence the expression of some miRNAs. These results provide the basic data of miRNA expression for the mechanism elucidation of the general anesthesia.
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Report
(4 results)
Research Products
(18 results)
