• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Evaluation of the acute inflammation using macrophages

Research Project

Project/Area Number 24592323
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Anesthesiology/Resuscitation studies
Research InstitutionYamagata University

Principal Investigator

KAWAMAE Kaneyuki  山形大学, 医学部, 教授 (70254026)

Co-Investigator(Kenkyū-buntansha) GOTO Kaoru  山形大学, 医学部, 教授 (30234975)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords急性炎症 / ストレス / 細胞内情報伝達機構 / 血球細胞 / マクロファージ / 炎症応答 / ヒト血球細胞 / LPS / イノシトールリン脂質 / 動物モデル / 脾臓 / 小胞体 / 細胞内情報伝達 / RT-PCR / mRNA / 単球 / T細胞 / PCR
Outline of Final Research Achievements

In the case of intensive care management, the prognosis depends on the severity of the inflammation. If we can quantitatively assess the inflammation using cell samples from patients, it would be useful in clinical practice. In the present study, we focused on human blood-derived cell line and investigated the expression levels of diacylglycerol kinase (DGK) family, an enzyme involved in intracellular signal transduction, under physiological and stimulatory conditions with LPS and IL2. We found that DGKepsilon is upregulated in the initial phase of inflammation, suggesting that this isozyme is intimately involved in the inflammatory process.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (11 results)

All 2015 2014 2013 2012

All Journal Article (5 results) (of which Peer Reviewed: 5 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (6 results) (of which Invited: 2 results)

  • [Journal Article] Development of a bronchospasm device model.2015

    • Author(s)
      Sugiura A, Kawamae K.
    • Journal Title

      J Anesth

      Volume: 29 Issue: 1 Pages: 152-155

    • DOI

      10.1007/s00540-014-1872-0

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Healthcare Technology Management (HTM) of mechanical ventilators by clinical engineers.2014

    • Author(s)
      Yoshioka J,Nakane M,Kawamae K.
    • Journal Title

      J Intensive Care

      Volume: 2 Issue: 1 Pages: 27-27

    • DOI

      10.1186/2052-0492-2-27

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Expression of mRNAs for the diacylglycerol kinase family in immune cellsduring an inflammatory reaction2014

    • Author(s)
      Yamamoto M, Tanaka T, Hozumi Y, Saino-Saito S, Nakano T, Tajima K, Kato T, Goto K.
    • Journal Title

      Biomedical Research

      Volume: 35 Issue: 1 Pages: 61-68

    • DOI

      10.2220/biomedres.35.61

    • NAID

      130004903860

    • ISSN
      0388-6107, 1880-313X
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Establishment of novel monoclonalantibodies KMab-1 and MMab-1 specificfor IDH2 mutations2013

    • Author(s)
      Kaneko MK, MoritaS, Tsujimoto Y, Yanagiya R, Nasu K,Sasaki H, Hozumi Y, Goto K, Natsume A,Watanabe M, Kumabe T, Takano S, KatoY
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 1;432(1) Issue: 1 Pages: 40-5

    • DOI

      10.1016/j.bbrc.2013.01.088

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] DGKzeta is involved in LPS-activated phagocytosis through IQGAP1/Rac1 pathway2012

    • Author(s)
      Okada, M.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 420 Issue: 2 Pages: 479-84

    • DOI

      10.1016/j.bbrc.2012.03.057

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] 一酵素ファミリーから見た生命現象―脂質性二次メッセンジャー代謝酵素ジアシルグリセロールキナーゼの機能解析2014

    • Author(s)
      後藤薫
    • Organizer
      第60日本解剖学会地方会
    • Place of Presentation
      福島県立医大、福島
    • Year and Date
      2014-09-06 – 2014-09-07
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Diacylglycerol kinaseζによるNFkB 制御機構2014

    • Author(s)
      土谷理恵子、飯野光喜、後藤薫
    • Organizer
      第119回日本解剖学会総会
    • Place of Presentation
      自治医科大学(栃木)
    • Related Report
      2013 Research-status Report
  • [Presentation] ε型ジアシルグリセロールキナーゼ欠損マウスの脂肪組織における 脂質代謝メカニズム解析2014

    • Author(s)
      中野知之、後藤薫
    • Organizer
      第119回日本解剖学会総会
    • Place of Presentation
      自治医科大学(栃木)
    • Related Report
      2013 Research-status Report
  • [Presentation] FUNCTIONAL IMPLICATIONS OF DIACYLGLYCEROL KINASE IN STRESS RESPONSE2013

    • Author(s)
      Kaoru Goto, Toshiaki Tanaka
    • Organizer
      ASahct 2013, International Symposium Anatomical Science for advance in health and clinical therapy
    • Place of Presentation
      Tohoku University (Sendai)
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] ε 型ジアシルグリセロールキナーゼの細胞内局在化機構と小胞体ストレスにおける機能的役割2013

    • Author(s)
      松井 祐興、後藤 薫
    • Organizer
      第118回 日本解剖学会総会
    • Place of Presentation
      サンポートホール高松(香川大学)、高松
    • Related Report
      2012 Research-status Report
  • [Presentation] Subcellular localization of Diacylglycerol kinase ε in transfected neurons2012

    • Author(s)
      Hirooki Matsui, Yasukazu Hozumi, Ken Iseki, Kaoru Goto
    • Organizer
      42th Annual Meeting of Neuroscience
    • Place of Presentation
      Convention Center, New Orleans, USA
    • Related Report
      2012 Research-status Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi