The effect of anesthetics on inhibitory networks in the central nucleus of amygdala
Project/Area Number |
24592324
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Anesthesiology/Resuscitation studies
|
Research Institution | University of Tsukuba |
Principal Investigator |
|
Co-Investigator(Renkei-kenkyūsha) |
KATO Fusao 慈恵会医科大学, 医学部, 教授 (20169519)
|
Project Period (FY) |
2012-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
Keywords | 扁桃体 / ノルアドレナリン / GABA / 抑制性神経伝達 / 扁桃体中心核 |
Outline of Final Research Achievements |
Pain promotes aversive memory formation and in turn exacerbates psycho-mental complications in the chronic pain patients. The central nucleus of amygdala plays essential role in emotional memory formation. Noradrenaline is a primary stress hormone in the CNS. We clarified that noradrenaline dramatically and reversibly increased inhibitory input to the medial division of the central nucleus of amygdala (CeM). A possible interpretation is that CeM neuron excitability is regulated by inhibitory inputs from the lateral and capsular divisions of CeA through alpha-1 receptor-mediated processes and from unidentified cell populations that are excited by beta receptor activation.
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Report
(4 results)
Research Products
(8 results)