The mechanisms of septic encephalopathy during sepsis

• Project/Area Number: 24592325
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Anesthesiology/Resuscitation studies
• Research Institution: Gunma University
• Principal Investigator: KADOI Yuji 群馬大学, 医学部附属病院, 准教授 (10292591)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 敗血症 / 脳障害 / ショック / 敗地症 / HMGB-1 / 中枢神経障害 / 脳症

Outline of Final Research Achievements

The purpose of this study was to identify the mechanism sof septic encephalopathy and to examine the effects of edaravone on septic encephalopathy. Decreased nneuronal activity was observed during septic shock induce by cecal ligation and puncture model. However, administration of edaravone could not improve the septic encephalopathy during septic shock.

Research Products

• [Journal Article] Comparative effects of flurbiprofen and fentanyl on natural killer cell cytotoxicity, lymphocyte subsets and cytokine concentrations in post-surgical intensive care unit patients : Prospective, randomized study (2014)
  • Author(s): Narahara H, Kadoi Y, Hinohara H, kunimoto F, Saito S
  • Journal Title: J Anesthesia Volume: ２７ Pages: 676-683
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Comparative effects of flurbiprofen and fentanyl on natural killer cell cytotoxicity, lymphocyte subsets and cytokine concentrations in post-surgical intensive care unit patients : Prospective, randomized study. (2013)
  • Author(s): Narahara H, Kadoi Y, Hinohara H, kunimoto F, Saito S
  • Journal Title: J Anesthesia Volume: 27 Pages: 676-683
  • Peer Reviewed
• [Journal Article] Effects of balloon-induced pulsatile perfusion on postoperative short- and long-term cognitive dysfunction in diabetic patients with impaired cerebrovascular carbon dioxide reactivity. (2013)
  • Author(s): Kadoi Y, Saito S, Fujita N, Mizutani A.
  • Journal Title: J Cardiothoracic Vascular Anesthesia Volume: 27 Pages: 238-244
  • Peer Reviewed
• [Journal Article] Blood glucose control in the perioperative period. (2012)
  • Author(s): Kadoi Y
  • Journal Title: Minerva Anestesiologica Volume: 78 Pages: 574-595
  • Peer Reviewed
• [Presentation] 非心臓手術後の認知障害 (2014)
  • Author(s): 門井雄司
  • Organizer: 第61回 日本麻酔科学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2014-05-21 – 2014-05-22
  • Invited
• [Presentation] 心臓手術と臓器保護 (2012)
  • Author(s): 門井雄司
  • Organizer: 日本心臓血管麻酔学会第17回学術大会
  • Place of Presentation: 仙台
  • Invited