| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
In this study, I have demonstrated the role of glycine receptors in the spinal cord that is involved in a pain sensation pathway. To inhibit the expression of glycine receptor α3 subunits in the rat spinal cord, siRNA was injected to the subarachnoid space. However, the responses to heat stimulus was not changed even after the injection of siRNA. This result suggested that glycine receptor α3 subunits did not have an essential role for the transmission of pain sensation under normal condition. I expect that this result would facilitate the study to uncover the role of glycine receptor α3 subunits in inflammatory pain.
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