| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Outline of Final Research Achievements |
Glucocorticoids play a significant role in the anti-inflammatory effects, however the mechanisms that systemic or epidural administrations of glucocorticoid reduce pain have not been clearly understood. Recent evidence shows that glucocorticoid might cause rapid effect through pathways other than the genomic pathway, which appears in seconds or a few minutes. Although these non-genomic effects have reported in many organs, there are few reports about the effect on sensory-related neuron until now. Glucocorticoid receptors have also been located in spinal cord dorsal horn neuron. To gain an understanding of the mechanisms, we investigated the rapid non-genomic effects of gluticorticoid, dexamethasone and hydrocortisone on excitatory synaptic transmission in the substantia gelatinosa (SG) neurons of the adult rat spinal cord. We found that dexamethasone and hydrocortisone did not alter presynaptic glutamate release.
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