Non-genomic antinociceptive effects of glucocorticoids on rat spinal cord

Research Project

Project/Area Number	24592330
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Anesthesiology/Resuscitation studies
Research Institution	Niigata University
Principal Investigator	IKOMA miho 新潟大学, 医歯(薬)学総合研究科, 特任准教授 (30432082)
Co-Investigator(Kenkyū-buntansha)	KOHNO Tatsuro 新潟大学, 医歯学系, 准教授 (00313536)
Project Period (FY)	2012-04-01 – 2015-03-31
Project Status	Completed (Fiscal Year 2014)
Budget Amount *help	¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000) Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords	ステロイド / 脊髄 / 疼痛 / パッチクランプ / 副腎皮質ステロイド
Outline of Final Research Achievements	Glucocorticoids play a significant role in the anti-inflammatory effects, however the mechanisms that systemic or epidural administrations of glucocorticoid reduce pain have not been clearly understood. Recent evidence shows that glucocorticoid might cause rapid effect through pathways other than the genomic pathway, which appears in seconds or a few minutes. Although these non-genomic effects have reported in many organs, there are few reports about the effect on sensory-related neuron until now. Glucocorticoid receptors have also been located in spinal cord dorsal horn neuron. To gain an understanding of the mechanisms, we investigated the rapid non-genomic effects of gluticorticoid, dexamethasone and hydrocortisone on excitatory synaptic transmission in the substantia gelatinosa (SG) neurons of the adult rat spinal cord. We found that dexamethasone and hydrocortisone did not alter presynaptic glutamate release.