| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
We examined the effects of volatile anesthetics on ischemic myocardial injury via transient receptor potential canonical (TRPC) channels. The cardiac microdialysis technique was applied to the rat transverse aortic constriction (TAC) model, which is an experimental model for pressure overload-induced cardiac hypertrophy with TRPC channels activation. Using these rat model, ischemia/reperfusion induced cardiac marker levels were elevated. These were suppressed by the pretreatment of 2-APB, SKF96365 (TRPC channel blocker) and sevoflurane. These results suggest that sevoflurane might exert an in vivo myocardial protective effect during ischemia/reperfusion through TRPC channels.
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